The Use of Endoscopic Ultrasound-Guided Fine Needle Aspiration (EUS-FNA) in Cytopathology Diagnosis

Zhu, Lee‐Ching; Feng, Qinghua; Grieco, Verena S.

doi:10.5772/52549

Cited by 2 publications

(1 citation statement)

References 110 publications

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“…Endoscopic ultrasonography (EUS) is utilized for visualization and sampling of both gastrointestinal (GI) subepithelial lesions (SELs) as well as tissues in surrounding organs. 1,2 EUS-guided fine needle aspiration cytology (EUS-FNA) is most commonly used to assess tumors involving the pancreas, lymph nodes adjacent to the GI tract and less commonly GI SELs. 3 GI SELs are incidentally encountered in less than 1% of all endoscopic procedures.…”

Section: Introductionmentioning

confidence: 99%

Comparison of endoscopic ultrasound‐guided fine needle aspiration cytology versus endoscopic biopsy for the diagnosis of subepithelial lesions of the upper and lower gastrointestinal tract: A 10‐year retrospective single institution analysis

Collins

Yocum

Mesa

et al. 2023

Diagnostic Cytopathology

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Background The aim of this study is to compare the diagnostic accuracy of endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) versus endoscopic biopsy for the diagnosis of gastrointestinal (GI) subepithelial lesions (SELs) using surgical resection as the gold standard. Methods All patients who underwent EUS‐FNA of upper and lower GI SELs over a 10‐year period (2010 through 2019) were retrospectively reviewed. The medical records of all patients were reviewed and data extracted from the endoscopy, pathology, and surgical reports were analyzed. Results In total, 283 patients with ages ranging from 21 to 92 years underwent EUS‐FNA for evaluation of GI SELs, 117 (41%) patients underwent endoscopic biopsy and 82 (29%) patients had concurrent surgical resection specimen. EUS‐FNA was obtained from the stomach in 167 (59%) patients, duodenum in 51 (18%) patients, esophagus in 38 (13%) patients, and colorectum in 27 (10%) patients. It was found that the largest percentage of lesions originated in the muscularis propria (36%), followed by the submucosa (26%), deep mucosa (13%), and not specified in 21%. The concordance between EUS‐FNA and endoscopic biopsy was good (correlation coefficient of 0.631, p < .001). EUS‐FNA versus endoscopic biopsy in resected cases showed sensitivity and specificity of 78% versus 68% and 84% versus 100%, respectively. The EUS‐FNA has an accuracy of 80% compared to 74% in biopsy. The diagnostic yield of EUS‐FNA and endoscopic biopsy was 64% versus 55%. Conclusion EUS‐FNA is more sensitive and more accurate than endoscopic biopsy for diagnosing GI SELs with a good concordance between the two techniques.

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Section: Introductionmentioning

confidence: 99%

Comparison of endoscopic ultrasound‐guided fine needle aspiration cytology versus endoscopic biopsy for the diagnosis of subepithelial lesions of the upper and lower gastrointestinal tract: A 10‐year retrospective single institution analysis

Collins

Yocum

Mesa

et al. 2023

Diagnostic Cytopathology

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Immunocytochemistry on scrape cellblock: An aid in the diagnosis of metastatic neoplasm with unknown primary: A series of four cases

Mathur

Sharma

et al. 2020

Cytojournal

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Scrape cellblock (SCB) is a novel technique to suggest possible primary site in fine-needle aspiration cytology (FNAC) smears from the liver, lung, and lymph nodes which are the common sites of metastasis of many primary tumors. Immunocytochemistry (ICC) on SCB averts the need of more invasive diagnostic procedures and gives a conclusive diagnosis. We present a series of four cases with unknown primary site, in which ICC was done on SCB to suggest possible primary site. Three of them were liver space-occupying lesions (SOL) and one from the periportal lymph node. In all four cases, wet-fixed smear for hematoxylin and eosin stain was prepared as routine procedure. FNAC was reported as metastatic adenocarcinoma in two and metastatic spindle cell neoplasm in one liver SOL. Periportal node was reported metastatic adenocarcinoma. Two hematoxylin and eosin-stained slides from each case with higher cellularity were used to scrape off the material to prepare SCB. ICC was put which gave conclusive diagnosis in all the cases. On ICC, two cases of metastatic carcinoma in the liver were diagnosed as metastatic neuroendocrine neoplasm from Gastrointestinal Tract and metastatic adenocarcinoma from the stomach. Spindle cell neoplasm of the liver was diagnosed as gastrointestinal stromal tumor from the stomach. Pancreatic head mass in metastatic periportal node was confirmed later by radiologic examination. SCB is a useful technique to make the best use of available material where reaspiration is difficult. ICC on SCB is of maximum utility to suggest possible primary sites in metastatic cases with unknown primary or where biopsy of the lesion is not possible.

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The Use of Endoscopic Ultrasound-Guided Fine Needle Aspiration (EUS-FNA) in Cytopathology Diagnosis

Cited by 2 publications

References 110 publications

Comparison of endoscopic ultrasound‐guided fine needle aspiration cytology versus endoscopic biopsy for the diagnosis of subepithelial lesions of the upper and lower gastrointestinal tract: A 10‐year retrospective single institution analysis

Comparison of endoscopic ultrasound‐guided fine needle aspiration cytology versus endoscopic biopsy for the diagnosis of subepithelial lesions of the upper and lower gastrointestinal tract: A 10‐year retrospective single institution analysis

Immunocytochemistry on scrape cellblock: An aid in the diagnosis of metastatic neoplasm with unknown primary: A series of four cases

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