The Use of Endobronchial Ultrasonography in Assessment of Bronchial Wall Remodeling in Patients With Asthma

Soja, Jerzy; Grzanka, Piotr; Sładek, Krzysztof; Okoń, Krzysztof; Ćmiel, Adam; Mikoś, Magdalena; Mikrut, S.; Pulka, Grażyna; Gross‐Sondej, Iwona; Niżankowska‐Mogilnicka, Ewa; Szczeklik, Andrzej

doi:10.1378/chest.08-2759

Cited by 49 publications

(43 citation statements)

References 25 publications

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“…This device can contain a number of tools and is capable of collecting various specimens, such as tissue biopsy specimens (with forceps or a needle), bronchial brushings, and bronchoalveolar lavage and can also be used to assess airway remodeling by means of endobronchial ultrasonography. 195 Although this procedure is safe, with low morbidity (0.1% to 2.5%) and very low mortality (<0.5%), 196 variability in the quality of the samples and the invasive nature of the technique limit its use for long-term assessment of the natural history of airway remodeling in asthmatic patients.…”

Section: Therapeutic Interventions and Remodelingmentioning

confidence: 99%

Remodeling in asthma

Al‐Muhsen¹,

Johnson²,

Hamid³

2011

Journal of Allergy and Clinical Immunology

368

293

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Section: Therapeutic Interventions and Remodelingmentioning

confidence: 99%

Remodeling in asthma

Al‐Muhsen¹,

Johnson²,

Hamid³

2011

Journal of Allergy and Clinical Immunology

368

293

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“…EBUS can access airways as small as 4mm of internal diameter and it can visualize multiple layers of the airway wall (Figure 6). Studies using EBUS demonstrated an increase in AWT in patients with asthma compared to healthy controls comparable to that measured by CT [34, 35]. Like OCT, EBUS offers the ability to monitor serial changes without exposure to ionizing radiation.…”

Section: Introductionmentioning

confidence: 99%

Using imaging as a biomarker for asthma

Trivedi

Hall

Hoffman

et al. 2017

Journal of Allergy and Clinical Immunology

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There have been significant advancements in the various imaging techniques that are being used in the evaluation of patients with asthma, both from a clinical and research perspective. Imaging characteristics can be used to identify specific asthmatic phenotypes and provide a more detailed understanding of endotypes contributing to the pathophysiology of the disease. Computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) can be used to assess pulmonary structure and function. It has been shown that specific airway and lung density measurements by CT correlate with clinical parameters including severity of disease and pathology but also provide unique phenotypes. Hyperpolarized 129Xe and 3He are gases used as contrast media for MRI that provide measurement of distal lung ventilation reflecting small airway disease. PET scanning can be useful to identify and target lung inflammation in asthma. Furthermore, imaging techniques can serve as a potential biomarker and be used to assess response to therapies, including newer biological treatments and bronchial thermoplasty.

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“…Bronchial wall thickness and wall area determined with EBUS in asthmatic and healthy subjects were comparable to CT morphometry [177]. Moreover, asthma subjects had thicker bronchial walls than the healthy controls on EBUS assessment.…”

Section: Endobronchial Ultrasonographymentioning

confidence: 53%

Novel imaging approaches in adult asthma and their clinical potential

Hartley

Baldi

Brightling

et al. 2015

Expert Review of Clinical Immunology

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Currently, imaging in asthma is confined to chest radiography and CT. The emergence of new imaging techniques and tremendous improvement of existing imaging methods, primarily due to technological advancement, has completely changed its research and clinical prospects. In research, imaging in asthma is now being employed to provide quantitative assessment of morphology, function and pathogenic processes at the molecular level. The unique ability of imaging for non-invasive, repeated, quantitative, and in vivo assessment of structure and function in asthma could lead to identification of 'imaging biomarkers' with potential as outcome measures in future clinical trials. Emerging imaging techniques and their utility in the research and clinical setting is discussed in this review.

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The Use of Endobronchial Ultrasonography in Assessment of Bronchial Wall Remodeling in Patients With Asthma

Cited by 49 publications

References 25 publications

Remodeling in asthma

Remodeling in asthma

Using imaging as a biomarker for asthma

Novel imaging approaches in adult asthma and their clinical potential

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