“…From the structural analysis of the two compounds compared, the common residues of the protein complex interacting with PB and E7107 were: V1078, V1110, V1114 and L1066 of the subunit SF3B1 and R38 and Y36 in the PHF5A subunit [ 57 ] . Starting from the two crystal structures, a pharmacophore map was created using LigandScout v.4.4 [ 46 , 47 ] , and geometrically common features were selected, thus removing two distal features. As a result, six common pharmacophoric features were found and the common pharmacophore was created [ Figure 1 ].…”