The use of diffusional kurtosis imaging and neurite orientation dispersion and density imaging of the brain in bipolar disorder

Ota, Miho; Noda, Takamasa; Sato, Noriko; Hidese, Shinsuke; Teraishi, Toshiya; Setoyama, Shiori

doi:10.1016/j.jad.2019.03.068

Cited by 13 publications

(18 citation statements)

References 29 publications

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“…For mood disorders, reduced ND and OD were found in major depressive disorder with a correlation between OD and disease severity. 58 In bipolar affective disorder, Ota et al 59 reported reduced ND in the right posterior cingulate cortex, although a previous study did not find any significant changes in bipolar affective disorder. 9 This discrepancy could be related with treatment, since another study reported that patient with bipolar affective disorder without lithium therapy showed lower ND in the left frontal cortex than those with lithium as well as than healthy controls.…”

Section: Psychiatric Disordersmentioning

confidence: 95%

<p>Neurite orientation and dispersion density imaging: clinical utility, efficacy, and role in therapy</p>

Sone¹

2019

RMI

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In the field of diffusion magnetic resonance imaging (MRI) for neuroimaging, white matter tracts have traditionally been analyzed using diffusion tensor imaging (DTI) measures, such as fractional anisotropy. However, recent advances in diffusion MRI have provided further information on brain microstructures using multi-shell protocols of diffusion MRI. Neurite orientation dispersion and density imaging (NODDI) is one such emerging advanced diffusion MRI method that enables investigation of the neurite density and neurite orientation dispersion of brain microstructures. NODDI was developed as a practical and clinically feasible diffusion MRI technique to evaluate the microstructural complexity of dendrites and axons. This review shed light on recent studies on the use of NODDI in human brain. Indeed, a growing number of studies are using NODDI to examine neurological and psychiatric disorders, with most reporting its clinical utility. The time has thus come, for us to seriously consider the clinical use of NODDI.

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Section: Psychiatric Disordersmentioning

confidence: 95%

<p>Neurite orientation and dispersion density imaging: clinical utility, efficacy, and role in therapy</p>

Sone¹

2019

RMI

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“…It's another advantage, compared to the other advanced diffusion imaging sequences, and is the easiness to perform. Its performance has been satisfactory and superior to DTI in identifying microstructural abnormalities in several neurodegenerative diseases and psychiatric disorders, including BD and MDD . As mentioned previously, the observations of the initial DKI studies are suggestive of microstructural differences between BD and MDD .…”

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confidence: 99%

“…Nevertheless, the existing DKI studies that attempted to identify or distinguish the microstructural alterations in BD and MDD are limited in number and fail to cover the whole brain (ie, the evaluation was limited to the gray matter nuclei and part of the cerebellum) . From the previous DTI and DKI reports of BD and MDD, these disorders can have different DKI characteristics in those areas still unexplored . Moreover, these characteristics may have clinical importance in distinguishing these two disorders or may serve as imaging indicators of disease severity.…”

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confidence: 99%

Microstructural Alterations in Bipolar and Major Depressive Disorders: A Diffusion Kurtosis Imaging Study

Sawamura

Narita

Hashimoto

et al. 2020

Magnetic Resonance Imaging

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Background Identifying structural and functional abnormalities in bipolar (BD) and major depressive disorders (MDD) is important for understanding biological processes. Hypothesis Diffusion kurtosis imaging (DKI) may be able to detect the brain's microstructural alterations in BD and MDD and any differences between the two. Study Type Prospective. Subjects In all, 16 BD patients, 19 MDD patients, and 20 age‐ and gender‐matched healthy volunteers. Field Strength/Sequence DKI at 3.0T. Assessment The major DKI indices of the brain were compared voxel‐by‐voxel among the three groups. Significantly different voxels were tested for correlation with clinical variables (ie, Young Mania Rating Scale [YMRS], 17‐item Hamilton Depression Rating Scale [17‐HDRS], Montgomery‐Åsberg Depression Rating Scale, total disease duration, duration of current episode, and the number of past manic/depressive episodes). The performance of the DKI indices in identifying microstructural alterations was estimated. Statistical Tests One‐way analysis of variance (ANOVA) was used for group comparison of DKI indices. The performance of these indices in detecting microstructural alterations was determined by receiver operating characteristic (ROC) analysis. Pearson's product–moment correlation analyses were used to test the correlations of these indices with clinical variables. Results DKI revealed widespread microstructural alterations across the brain in each disorder (P < 0.05). Some were significantly different between the two disorders. Mean kurtosis (MK) in the gray matter of the right inferior parietal lobe was able to distinguish BD and MDD with an accuracy of 0.906. A strong correlation was revealed between MK in that region and YMRS in BD patients (r = −0.641, corrected P = 0.042) or 17‐HDRS in MDD patients (r = −0.613, corrected P = 0.030). There were also strong correlations between a few other DKI indices and disease duration (r = −0.676 or 0.626, corrected P < 0.05). Data Conclusion DKI detected microstructural brain alterations in BD and MDD. Its indices may be useful to distinguish the two disorders or to reflect disease severity and duration. Level of Evidence 2 Technical Efficacy Stage 3 J. Magn. Reson. Imaging 2020;52:1187–1196.

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“…[18][19][20] One study examined plasmalogen levels in red cell membrane among patients with BP I and healthy controls; however, there were no significant differences between the two groups. 21 To date, numerous studies have attempted to identify biomarkers for BP [22][23][24][25][26][27] ; however, to our knowledge, none of these have explored the relationship of the blood plasma or serum ethanolamine phospholipid levels with BP.…”

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Altered ethanolamine plasmalogen and phosphatidylethanolamine levels in blood plasma of patients with bipolar disorder

Ogawa

Hattori

Ota

et al. 2020

Psychiatry Clin Neurosci

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Aim Ethanolamine‐containing phospholipids are synthesized in endoplasmic reticulum (ER) and mitochondria. ER stress and mitochondrial dysfunction have been implicated in bipolar disorder (BP). In this study, we aimed to examine the relationship of ethanolamine plasmalogen (PLE) and phosphatidylethanolamine (PTE) levels in blood plasma with BP. Methods Plasma PLE and PTE levels were compared between 34 patients with BP (DSM‐IV) and 38 healthy control participants matched for age, sex, and ethnicity (Japanese). Furthermore, the relationships of plasma PLE and PTE levels with clinical variables were explored. Results Plasma PLE levels were significantly lower in patients with BP than in healthy controls (P = 0.0033). In subgroup analyses, plasma PLE levels were significantly lower in patients with BP type I (BP I) than in healthy controls (P = 0.0047); furthermore, plasma PTE levels were significantly lower in patients with BP I than in controls (P = 0.016) and patients with BP type II (BP II) (P = 0.010). Receiver‐operating characteristic curve analysis revealed that the discriminatory power of plasma PTE levels for distinguishing between BP I and II was fair (area under the curve = 0.78; P = 0.0095). There were no significant correlations of plasma PLE or PTE levels with depression or manic symptoms in patients. Conclusions Plasma PLE and PTE levels were associated with BP I, but not with BP II. Moreover, plasma PTE levels differed between patients with BP I and II. Our findings highlight the importance of ethanolamine phospholipids in the pathophysiology of BP, especially BP I.

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The use of diffusional kurtosis imaging and neurite orientation dispersion and density imaging of the brain in bipolar disorder

Cited by 13 publications

References 29 publications

<p>Neurite orientation and dispersion density imaging: clinical utility, efficacy, and role in therapy</p>

<p>Neurite orientation and dispersion density imaging: clinical utility, efficacy, and role in therapy</p>

Microstructural Alterations in Bipolar and Major Depressive Disorders: A Diffusion Kurtosis Imaging Study

Altered ethanolamine plasmalogen and phosphatidylethanolamine levels in blood plasma of patients with bipolar disorder

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