The Use of Cyanoacrylate Adhesives in the Management of Congenital Vascular Malformations

Rosen, Robert J.; Contractor, Sohail

doi:10.1055/s-2004-831406

Cited by 56 publications

(49 citation statements)

References 17 publications

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“…The glue, N-butyl cyanoacrylate (NBCA), emerged as an embolic material in the 1980s and was approved for use by the U.S. FDA in 2000 for the treatment of cerebral arteriovenous malformations [58,59]. In its monomer form, NBCA is a clear liquid that polymerizes to form a rigid matrix upon activation by contact with any ionic substances ( e.g., blood, saline, ionic contrast media, and vascular endothelium) [59].…”

Section: Commercially Available Materialsmentioning

confidence: 99%

“…In its monomer form, NBCA is a clear liquid that polymerizes to form a rigid matrix upon activation by contact with any ionic substances ( e.g., blood, saline, ionic contrast media, and vascular endothelium) [59]. Trufill ® marketed by Cordis Neurovascular, Inc., provides physicians with a glue kit consisting of NBCA, ethiodized oil, and tantalum powder, which are combined on site just prior to use.…”

Section: Commercially Available Materialsmentioning

confidence: 99%

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Polymeric materials for embolic and chemoembolic applications

Poursaid

Jensen

Huo

et al. 2016

Journal of Controlled Release

111

103

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Percutaneous transcatheter embolization procedures involve the selective occlusion of blood vessels. Occlusive agents, referred to as embolics, vary in material characteristics including chemical composition, mechanical properties, and the ability to concurrently deliver drugs. Commercially available polymeric embolics range from gelatin foam to synthetic polymers such as poly(vinyl alcohol). Current systems under investigation include tunable, bioresorbable microspheres composed of chitosan or poly(ethylene glycol) derivatives, in situ gelling liquid embolics with improved safety profiles, and radiopaque embolics that are trackable in vivo. This article reviews commercially available materials used for embolization as well as polymeric materials that are under investigation.

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Section: Commercially Available Materialsmentioning

confidence: 99%

Section: Commercially Available Materialsmentioning

confidence: 99%

Polymeric materials for embolic and chemoembolic applications

Poursaid

Jensen

Huo

et al. 2016

Journal of Controlled Release

111

103

View full text Add to dashboard Cite

show abstract

“…Cyanoacrylate adhesive is currently extensively used in interventional radiology [24,25]. Studies have been conducted to compare the various cyanoacrylates in order to test their practicality and safety of use [26,27].…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic sacrocolpopexy with a vaginal prosthetic adhesive

Estrade¹,

Gurriet²,

Franquebalme³

et al. 2015

Gynécologie Obstétrique & Fertilité

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“…Trufill n-BCA is an adhesive, low-viscosity liquid embolic, which polymerizes rapidly. It was approved by the FDA in 2000 for presurgical embolization for arteriovenous malformations [10,11]. The use of cyanoacrylates in an exclusive cohort of intracranial infectious aneurysms prior to open heart surgery has not been previously reported.…”

Section: Discussionmentioning

confidence: 99%

Endovascular Embolization of Intracranial Infectious Aneurysms in Patients Undergoing Open Heart Surgery Using n-Butyl Cyanoacrylate

et al. 2017

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Introduction: Mycotic aneurysms are a serious complication of infective endocarditis with increased risk of intracranial hemorrhage. Patients undergoing open heart surgery for valve repair or replacement are exposed to anticoagulants, increasing the risk of aneurysm bleeding. These patients may require endovascular or surgical aneurysm treatment prior to heart surgery, but data on this approach are scarce. Methods: Retrospective review of consecutive patients with infectious endocarditis and mycotic aneurysms treated endovascularly with Trufill n-butyl cyanoacrylate (n-BCA) at the Cleveland Clinic between January 2013 and December 2015. Results: Nine patients underwent endovascular treatment of mycotic aneurysms with n-BCA (mean age of 39 years). On imaging, 4 patients had intracerebral hemorrhage, 2 had multiple embolic infarcts, and the rest had no imaging findings. Twelve mycotic aneurysms were detected (3 patients with 2 aneurysms). Seven aneurysms were in the M4 middle cerebral artery segment, 4 in the posterior cerebral artery distribution, and 1 in the callosomarginal branch. n-BCA was diluted in ethiodized oil (1:1 to 1:2). Embolization was achieved in a single rapid injection with immediate microcatheter removal. Complete aneurysm exclusion was achieved in all cases without complications. All patients underwent open heart surgery and endovascular embolization within a short interval, 2 with both procedures on the same day. There were no new hemorrhages after aneurysm embolization. Conclusions: Endovascular embolization of infectious intracranial aneurysms with liquid embolics can be performed successfully in critically ill patients requiring immediate open heart surgery and anticoagulation. Early embolization prior to and within a short interval from open heart surgery is feasible.

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The Use of Cyanoacrylate Adhesives in the Management of Congenital Vascular Malformations

Cited by 56 publications

References 17 publications

Polymeric materials for embolic and chemoembolic applications

Polymeric materials for embolic and chemoembolic applications

Laparoscopic sacrocolpopexy with a vaginal prosthetic adhesive

Endovascular Embolization of Intracranial Infectious Aneurysms in Patients Undergoing Open Heart Surgery Using n-Butyl Cyanoacrylate

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