The Use of Cryotherapy in the Gout Pain Control: A Systematic
                    Review

Tavares, Alana Ludemila de Freitas; Ross, Iranilda Moha; Pradal, Lilian Araujo; Neves, Morgana; Jamilk, Bárbara Heloise Trombetta; Bertolini, Gladson Ricardo Flôr

doi:10.29273/jmst.2021.5.1.1

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…In addition, prior to this recent study, we presented results of significantly reduced pain and increased QoL after receiving the immersion in water intervention (Kurniasari et al, 2022). These results could be an anesthetic effect of cooling therapy (Kurniasari et al, 2022; Mutlu & Yılmaz, 2020; Schlesinger, 2006; Schlesinger et al, 2002; Tavares et al, 2021) that in turn escalated the QoL level (Katz, 2002; Kurniasari et al, 2022). On the other hand, a study that applied local ice therapy to gout arthritis suggested that the reduced pain was because of lower inflammation in the joint (Schlesinger et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Immersion in Water Between 20-30^oC Mediated Inflammations Marker to Reduced Pain Among Indonesian With Gout Arthritis: A Community-Based Randomized Controlled Trial

Kurniasari

Karwur

Rayanti

et al. 2022

Biological Research For Nursing

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Background Gout is triggered by high urate levels and causes inflammation, pain, and an impaired quality of life. Immersion in water at 20–30°C reduces inflammation and pain in arthritis. Yet, relationships of immersion in water at 20–30°C with urate levels and the nucleotide-binding domain (NOD)-like receptor protein 1 (NLRP1) inflammasome have never been clarified. Objectives We aimed to investigate the effects of immersion in water at 20–30°C on urate levels, the NLRP1 inflammasome, pain, and quality of life among acute gout patients. Methods A community-based randomized control trial design was used with 2 parallel-intervention groups: immersion in water at 20–30°C (20 min/day for 4 weeks) group and a control group. In total, 76 eligible participants in Tomohon City, Indonesia, were assigned using block randomization. We analyze the results (coef. β) and 95% confidence intervals (CIs) using a generalized estimating equation model. We analyzed mediating effects using a path analysis. Results Significant pain alleviation ( β = −2.06 [95% CI = −2.67∼-1.45]; β = −2.42 [95% CI = −2.97∼-1.87]) and improved quality of life ( β = 5.34 [95% CI = 3.12–7.57]; β = 9.93 [95% CI = 7.02–12.83]) were detected at 2 and 4 weeks of follow-up compared to the pre-test and control group. Urate levels ( β = −0.34 [95% CI = −0.52∼-0.16]) were reduced at the 2-week follow-up, but there was no significant change in the NLRP1 inflammasome compared to the pre-test and control group after immersion in water at 20–30°C. Both the NLRP1 inflammasome ( β = −0.48 [95% CI = −0.63∼-0.34]); water 0.01) and urate levels ( β = −0.11 [95% CI = −0.24∼-0.03]; p < 0.01) had partial indirect (mediating) effects on the link between immersion in water at 20–30°C and pain at the 4-week follow-up. Conclusions Immersion in water at 20–30°C significantly decreased pain and increased the quality of life. Immersion in water at 20–30°C mediated NLRP1 and urate levels to decrease pain, although it had no significant effect on the NLRP1 inflammasome concentration after 4 weeks of follow-up and reduced urate levels only at 2 weeks after immersion in water at 20–30°C.

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Section: Discussionmentioning

confidence: 99%

Immersion in Water Between 20-30^oC Mediated Inflammations Marker to Reduced Pain Among Indonesian With Gout Arthritis: A Community-Based Randomized Controlled Trial

Kurniasari

Karwur

Rayanti

et al. 2022

Biological Research For Nursing

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“…This helps to reduce stiffness, increase range of movement and joint function. So, physiotherapy is a successful way of managing symptoms related with gout (de Freitas Tavares et al, 2021) [8] .…”

Section: Effect Of Physiotherapy To Control Goutmentioning

confidence: 99%

Untitled

2023

J. Curr. Res. Food Sci.

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Increased levels of uric acid in the blood cause gout, a chronic and progressive disease. This causes urate crystals to develop in our joints, which causes inflammation and encourages gout attacks. Gout, a form of arthritis, results in painful, joint stiffness and decrement of joint space. Strengthening of muscles along with the biomechanical correction as much as possible, also maintenance and improving the joint range of motion reducing joint pain, increasing the mobility which are the benefits of physiotherapy. The act of walking may be painful or challenging in some cases of acute or, chronic joint discomfort. There are four stages that gout can go through. Asymptomatic hyperuricemia is the first stage, followed by acute gout, inter-critical gout, and chronic tophaceous gout as the fourth stage. Complex carbohydrate, low protein, low fat (mainly from MUFA and PUFA), high fibre, suitable vitamins, minerals, and adequate hydration intake are recommended for patients who are having goutrelated symptoms. On the other hand, physiotherapy is essential in the treatment of gout in addition to diet. In this review article, the effectiveness of diet and physiotherapy in reducing gout-related symptoms is reviewed.

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Acute effects of photobiomodulation applied on the dorsal root ganglion in gout model-induced rats

Coracini¹,

Zazula²,

Scarton³

et al. 2023

Journal of Photochemistry and Photobiology B: Biology

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The Use of Cryotherapy in the Gout Pain Control: A Systematic Review

Cited by 4 publications

References 19 publications

Immersion in Water Between 20-30^oC Mediated Inflammations Marker to Reduced Pain Among Indonesian With Gout Arthritis: A Community-Based Randomized Controlled Trial

Immersion in Water Between 20-30^oC Mediated Inflammations Marker to Reduced Pain Among Indonesian With Gout Arthritis: A Community-Based Randomized Controlled Trial

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Acute effects of photobiomodulation applied on the dorsal root ganglion in gout model-induced rats

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The Use of Cryotherapy in the Gout Pain Control: A Systematic Review

Cited by 4 publications

References 19 publications

Immersion in Water Between 20-30oC Mediated Inflammations Marker to Reduced Pain Among Indonesian With Gout Arthritis: A Community-Based Randomized Controlled Trial

Immersion in Water Between 20-30oC Mediated Inflammations Marker to Reduced Pain Among Indonesian With Gout Arthritis: A Community-Based Randomized Controlled Trial

Untitled

Acute effects of photobiomodulation applied on the dorsal root ganglion in gout model-induced rats

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Immersion in Water Between 20-30^oC Mediated Inflammations Marker to Reduced Pain Among Indonesian With Gout Arthritis: A Community-Based Randomized Controlled Trial

Immersion in Water Between 20-30^oC Mediated Inflammations Marker to Reduced Pain Among Indonesian With Gout Arthritis: A Community-Based Randomized Controlled Trial