The Use of Cryotherapy for Papilloma and Early Laryngeal Cancers

Benninger, Michael S.; Derakhshan, Adeeb; Milstein, Claudio F.

doi:10.1177/0003489414566266

Cited by 6 publications

(4 citation statements)

References 31 publications

(30 reference statements)

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“…The morbidity of RRP is exceedingly high due to the recurrent nature of the disease and a lack of satisfactory treatment options. RRP symptom management is limited to repeated surgical procedures to remove lesions [ 11 , 12 ]. Procedures are uncomfortable, costly, and inconvenient for patients, and can injure and scar vocal fold tissues, which further impairs voice production [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel In Vivo Model of Laryngeal Papillomavirus-Associated Disease Using Mus musculus Papillomavirus

King

Bilger

Rademacher

et al. 2022

Viruses

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Recurrent respiratory papillomatosis (RRP), caused by laryngeal infection with low-risk human papillomaviruses, has devastating effects on vocal communication and quality of life. Factors in RRP onset, other than viral presence in the airway, are poorly understood. RRP research has been stalled by limited preclinical models. The only known papillomavirus able to infect laboratory mice, Mus musculus papillomavirus (MmuPV1), induces disease in a variety of tissues. We hypothesized that MmuPV1 could infect the larynx as a foundation for a preclinical model of RRP. We further hypothesized that epithelial injury would enhance the ability of MmuPV1 to cause laryngeal disease, because injury is a potential factor in RRP and promotes MmuPV1 infection in other tissues. In this report, we infected larynges of NOD scid gamma mice with MmuPV1 with and without vocal fold abrasion and measured infection and disease pathogenesis over 12 weeks. Laryngeal disease incidence and severity increased earlier in mice that underwent injury in addition to infection. However, laryngeal disease emerged in all infected mice by week 12, with or without injury. Secondary laryngeal infections and disease arose in nude mice after MmuPV1 skin infections, confirming that experimentally induced injury is dispensable for laryngeal MmuPV1 infection and disease in immunocompromised mice. Unlike RRP, lesions were relatively flat dysplasias and they could progress to cancer. Similar to RRP, MmuPV1 transcript was detected in all laryngeal disease and in clinically normal larynges. MmuPV1 capsid protein was largely absent from the larynx, but productive infection arose in a case of squamous metaplasia at the level of the cricoid cartilage. Similar to RRP, disease spread beyond the larynx to the trachea and bronchi. This first report of laryngeal MmuPV1 infection provides a foundation for a preclinical model of RRP.

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Section: Introductionmentioning

confidence: 99%

A Novel In Vivo Model of Laryngeal Papillomavirus-Associated Disease Using Mus musculus Papillomavirus

King

Bilger

Rademacher

et al. 2022

Viruses

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“…Other methods that could be considered for debulking a tumour like this are C02-laser, a micro-debrider and cryotherapy [ 6 , 19 , 20 ]. In this case, micro-debrider surgery and cryotherapy were dismissed due an increased risk of trauma to surrounding tissues and a lack of evidence, respectively [ 20 ]. We chose coblation because it has a long track record as an operative modality, is widely available, and allows a bloodless field [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Coblation debulking of a paediatric laryngeal plexiform neurofibroma: a pragmatic response to a rare tumour

Schuster-Bruce¹,

Kelly²,

Bernic³

et al. 2022

Journal of Surgical Case Reports

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Laryngeal neurofibroma is a rare but important differential diagnosis in a patient presenting with stridor. In paediatric patients, these lesions present a management conundrum: complete surgical resection is the established treatment of choice, but an aggressive approach can be detrimental to developing anatomy. We report the case of a plexiform neurofibroma affecting the right hemilarynx of a 3-year-old boy. Endoscopy revealed a large tumour, involving the right aryepiglottic fold and extending into the piriform sinus, ventricle and the false cord. Given the patient’s young age and the challenging tumour location, the lesion was debulked, rather than resected, using coblation (low-temperature plasma radiofrequency ablation). At 30 months follow-up, the neurofibroma has mildly increased in size—in line with expectations that these lesions exhibit slow growth throughout childhood—but there are no significant respiratory symptoms and there is no functional impairment.

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“…Although emphasis has been placed on cryotherapy as a treatment for laryngeal cancer, several studies address the success of the use of cryotherapy as a treatment for papillomatosis. 86,90 Cryotherapy has the potential to be a medical treatment for laryngeal diseases resulting in minimal scarring and optimal postoperative voice quality and is therefore an important topic for future research. For one, future research should continue to look at the healing process of cryotherapy, exploring the healing environment produced and how it results in minimal scarring.…”

Section: Tissue Effectsmentioning

confidence: 99%

Phonosurgery: A review of current methodologies

Ulmschneider

Baker

Vize

et al. 2021

World j. otorhinolaryngol.-head neck surg.

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Cold‐steel has served as the gold standard modality of phonosurgery for most of its history. Surgical laser technology has revolutionized this field with its wide use of applications. Additional modalities have also been introduced such as coagulative lasers, photodynamic therapy, and cryotherapy. This review will compare the surgical modalities of cold steel, surgical lasers, phototherapy and cryotherapy. The mechanism of action, tissue effects and typical uses will be addressed for each modality.

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The Use of Cryotherapy for Papilloma and Early Laryngeal Cancers

Cited by 6 publications

References 31 publications

A Novel In Vivo Model of Laryngeal Papillomavirus-Associated Disease Using Mus musculus Papillomavirus

A Novel In Vivo Model of Laryngeal Papillomavirus-Associated Disease Using Mus musculus Papillomavirus

Coblation debulking of a paediatric laryngeal plexiform neurofibroma: a pragmatic response to a rare tumour

Phonosurgery: A review of current methodologies

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