The use of conventional and invaginated autologous vein grafts for nerve repair by means of entubulation

Kelleher, Michael O.; Al-Abri, Rashid; Eleutério, Maria Lúcia; Myles, L. M.; Lenihan, D. V.; Glasby, M. A.

doi:10.1054/bjps.2000.3471

Cited by 29 publications

(21 citation statements)

References 14 publications

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“…The authors used a vein graft as a conduit to provide a scaffold for BMSCs and to facilitate Schwann cell migration. The vein has been utilized as a conduit to repair segmental nerve tissue loss which proved to be supportive conduit for peripheral nerve axonal regeneration and maturity 1,2,19,27 .…”

Section: Discussionmentioning

confidence: 99%

The use of undifferentiated bone marrow stromal cells for sciatic nerve regeneration in rats

Mohammadi¹,

Azizi²,

Delirezh³

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

The use of undifferentiated bone marrow stromal cells for sciatic nerve regeneration in rats

Mohammadi¹,

Azizi²,

Delirezh³

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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“…Although Wang et al 3 supported the contention that the inside-out vein technique conferred not only structural but also functional benefit, Kelleher et al 38 found that the superior morphometric results seen in the inside-out group were not matched by improved functional recovery over standard vein, as measured by electrophysiological parameters.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effect of nerve growth factor‐7S on peripheral nerve regeneration through inside‐out vein grafts: An experimental study

et al. 2004

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This study investigated the effect of local administration of nerve growth factor-7S (NGF-7S) on the axonal regrowth of mixed peripheral nerves through inside-out vein grafts. Sixty male Wistar rats were randomized into two groups (n = 30). A defect 12 mm long in the right sciatic nerve was created and repaired with an inside-out vein graft from the right jugular vein. NGF-7S (group A) or phosphate-buffered saline (group B; control) was locally administered daily during the first 3 weeks. Walking-track analysis and electrophysiological and histological-morphometric studies were carried out 4, 6, 8, 10, and 12 weeks postoperatively (subgroups a, b, c, d, and e, respectively, n = 6 each). Data analysis showed that 1) the recovery of motor function, as measured by walk pattern analysis and evoked muscle action potential, and 2) the orientation, number, myelin thickness, and diameter of myelinated fibers were better in the NGF-7S than in the control group. These findings present strong evidence of the beneficial effect of NGF-7S on peripheral nerve regeneration through inside-out vein grafts.

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“…[9][10][11] Although this technique showed promise, it was not as successful as hoped, with some published data finding no significant difference between standard and inside-out veins. 12,13 Arteries were first successfully used as nerve guides by Bungner in 1891. 14 Although chemically similar to veins, several physical characteristics such as wall thickness, permeability, and mechanical rigidity differ.…”

Section: Introductionmentioning

confidence: 99%

Inverted human umbilical arteries with tunable wall thicknesses for nerve regeneration

Crouzier¹,

McClendon²,

Tosun³

et al. 2008

J Biomedical Materials Res

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Tubular nerve guides have shown a potential to bridge nerve defects, by directing neuronal elongation, localizing growth factors, and inhibiting fibrotic cellular ingrowth. These investigations describe a novel acellular scaffold derived from the human umbilical cord artery that aims to enhance nerve regeneration by presenting a unique mechanical and chemical environment to the damaged nerve ends. A rapid, semiautomated dissection technique is described that isolates the human umbilical artery (HUA) from the umbilical cord, after which the vessel is decellularized using sodium dodecyl sulfate (SDS). The artery is turned inside out to produce a 3D scaffold, that unlike previous vessels for nerve repair, is more resistant to collapse. The scaffold has the potential as either an acellular bridge-implant, or for in vitro nerve regeneration. Stress-strain relationships and suture retention were assessed to determine whether the material had similar mechanical properties to native nerves. A dual process-flow perfusion bioreactor was developed to assess glucose mass transfer, and to investigate the culture of neuronal-like PC12 cells within the scaffold. These investigations have shown the automated dissecting method yields a smooth tubular scaffold, where wall thickness can be tuned to alter the mechanical behavior of the scaffold. Inverting the scaffold prevents collapse, with the decellularized iHUA having comparable mechanical properties to native nerves. Bioreactor cultures with PC12 cells seeded within iHUA lumenal void were shown to adhere and migrate into the preexisting ECM after 11 days of culture. These investigations show the potential of the iHUA as a unique 3D scaffold that may enhance nerve regeneration.

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The use of conventional and invaginated autologous vein grafts for nerve repair by means of entubulation

Cited by 29 publications

References 14 publications

The use of undifferentiated bone marrow stromal cells for sciatic nerve regeneration in rats

The use of undifferentiated bone marrow stromal cells for sciatic nerve regeneration in rats

Beneficial effect of nerve growth factor‐7S on peripheral nerve regeneration through inside‐out vein grafts: An experimental study

Inverted human umbilical arteries with tunable wall thicknesses for nerve regeneration

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