The use of computed tomography to quantitate bone formation after distraction epiphysiolosis in the rabbit

Roermund, P.M. van; Romeny, Bart M. ter Haar; Schoonderwoert, G. J.; Brandt, C. J. W. M.; Sijbrandij, S; Renooij, Willem

doi:10.1007/bf00349929

Cited by 21 publications

(10 citation statements)

References 4 publications

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“…Chances of observing an effect from an added external stimulus might be highest as early in the distraction phase as possible. Van Roermund et al (35) reported that in this rabbit tibia elongation model, active net bone formation occurred from the start of the distraction until 3-4 weeks after reaching maximal elongation.…”

Section: Discussionmentioning

confidence: 78%

Effect of direct current stimulation on bone growth after distraction epiphysiolysis of the rabbit tibia

Roermund

Hoekstra

Visser

et al. 1990

Journal Orthopaedic Research

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The effect of direct current stimulation on bone formation during limb lengthening was tested in a lower leg lengthening model in the rabbit. Limb lengthening was performed by distraction epiphysiolysis. A specially designed external distraction device was placed at the tibia. The distractor allowed 10 mm of lengthening in 4 weeks. Two weeks after starting the distraction, a platinum electrode was passed through the anterior cortex below the tibial tuberosity and advanced via the medullary cavity so that the tip rested in the elongated zone. Stimulation started at the time of placement of the electrodes and was continued for 3 weeks. The electrode in the elongated zone served as the cathode; the anode was placed subcutaneously. A 20 microA stimulus was selected. A control group received the same treatment without stimulation. Bone formation in the elongated zone was evaluated by histology and scintigraphy. The data from this experiment show that direct current stimulation in the early phase of a limb lengthening procedure had no effect on the extent of bone formation in the elongated zone.

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Section: Discussionmentioning

confidence: 78%

Effect of direct current stimulation on bone growth after distraction epiphysiolysis of the rabbit tibia

Roermund

Hoekstra

Visser

et al. 1990

Journal Orthopaedic Research

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“…1,13,17,19,39 Therefore, the original hypothesis in the current study could not be proved. It seems that calcitonin cannot accelerate maturation of regenerate bone, at least under the conditions and standards of the current experiment and as far as DEXA is able to appreciate such an effect.…”

Section: Discussionmentioning

confidence: 85%

“…The current model along with the relative technical parameters (operative technique, waiting period, and rate and speed of lengthening) were based on the literature and the authors' pilot studies. [17][18][19]23,39 …”

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confidence: 99%

Calcitonin Administration in a Rabbit Distraction Osteogenesis Model

Kokoroghiannis¹,

Papaioannou²,

Gp³

et al. 2003

Clinical Orthopaedics and Related Research

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The effect of salmon calcitonin on the maturation of the regenerate bone was assessed in an experimental model in rabbits. Twenty-six New Zealand White male rabbits, approximately 5 months old and weighing 3 to 3.5 kg, were subjected to a mid-diaphyseal tibial osteotomy. After 5 days, the right tibia was lengthened gradually at a rate of 0.375 mm every 12 hours, for 10 days. Ten international units of salmon calcitonin were administered daily subcutaneously to the study group (14 animals), whereas the animals of the control group (12 animals) were injected with a placebo, for the duration of the experiment. The bone mineral density of the regenerate bone was assessed on Days 20, 35, 45, and 55 of the experiment, in both groups, using dual energy xray absorptiometry. No statistical significant difference was found in the dual energy xray absorptiometry measurements between the study and control groups regarding the change of the bone mineral density of the new bone relative to a preoperative baseline measurement. Characteristic time-related changes were observed in the bone mineral density of the regenerate bone during its maturation, which proved to be identical in both groups. It seems that the administration of calcitonin does not enhance regenerate bone mineralization rate and tendency during bone lengthening.

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“…Moreover, these characteristics appear to be long-standing, in contrast to lengthening in which the newly formed bone tends to assume characteristics similar to that of the contralateral bone [1][2][3]. In particular, in bone transport the regenerated osseous segments consistently presented a cortical thickness and density that were less than that of the contralateral segment, with an enlargement of the medullary canal (Figs.…”

Section: Discussionmentioning

confidence: 99%

CT evaluation of regenerated osseous segments following bone transport

Iacobellis

Bulzacchi²,

Rioda

2004

J Orthopaed Traumatol

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IntroductionNewly formed bone with distractional osteogenesis after bone transport presents morphological characteristics that are different from the contralateral bone segment. These differences are visible upon radiographic examination, which can show increased diameter of the newly formed bone. The information given by radiography (anteroposterior and lateral view) is not however sufficient for precise definition of the morphological characteristics of the regenerated segment and, consequently, is inadequate for assessment of mechanical quality. With reference to several earlier morphological and quantitative studies of regenerated bone after lengthening [1-3], we chose to examine similar properties (thickness of the cortical wall, sectional area of the newly formed medullary canal, density of the regenerated bone fragment in the cortical and medullary components) of corticalized, regenerated bone in order to assess any possible relationships to clinical utility. O R I G I N A L Abstract A morphological analysis using radiography and computed tomography was performed in a total of 17 bone segments following single or double bone transport in 11 and 3 patients, respectively. All bone transports involved the tibia, with the exception of 2 single bone transports, which were femoral. The following parameters were measured: cortical wall thickness, sectional area of the medullary canal, and density of the cortical bone and medullary canal in Hounsfield units (HU). The regenerated segments showed a cortical thickness and density that were less than the contralateral portion, with an enlargement of the medullary canal and an increase in density due to the presence of cancellous bone in the medullary area. Successive controls showed an increase in thickness and density of the cortical bone and a small reduction in the diameter of the medullary canal and its cancellous bone. The variations in the cortical and the medullary canal appeared to be independent of the length of the regenerated segment. In the 3 tibia treated by double bone transport, the anatomical variations in the distal regenerated portion varied less from normal values than the proximal portion of the same segment. In the 2 femurs examined, enlargement of the regenerated section was smaller with respect to cases involving regeneration of the proximal tibia. These differences are presumably dependent on the fact that in the latter case, a more vascularized segment is produced after osteotomy in spongy bone, with respect to those involving the distal tibia or femur. Double transport is preferable due to the reduced treatment times.

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The use of computed tomography to quantitate bone formation after distraction epiphysiolosis in the rabbit

Cited by 21 publications

References 4 publications

Effect of direct current stimulation on bone growth after distraction epiphysiolysis of the rabbit tibia

Effect of direct current stimulation on bone growth after distraction epiphysiolysis of the rabbit tibia

Calcitonin Administration in a Rabbit Distraction Osteogenesis Model

CT evaluation of regenerated osseous segments following bone transport

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