The use of compound muscle action potentials (CMAP) for postoperative monitoring of free functioning gracilis muscle transfer: A preliminary report

Khater, Amr M.E.; Doi, Kazuteru; Hattori, Yasunori; Sakamoto, Soutetsu; Yonemura, Hiroshi; Kumar, Kannan Karuppiah

doi:10.1016/j.bjps.2015.02.006

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…In the case of semi-buried or buried flaps, the microsurgeon has a range of monitoring methods to choose from but not all are suitable, as many still require contact with the flap surface 4,6,33 , they can be limited by the depth of penetration 8,[34][35][36][37][38][39] , and some are appropriate to monitor a particular tissues type only [40][41][42][43][44][45] . In these circumstances the most commonly used techniques are Doppler ultrasound, laser Doppler flowmetry, spectroscopy or plethysmography 3 .…”

Section: Resultsmentioning

confidence: 99%

The use of sentinel skin islands for monitoring buried and semi-buried micro-vascular flaps. Part II: Clinical application

Molitor¹,

Měšťák²,

Pink³

et al. 2021

BIOMED PAP

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Despite the high success rate of micro-vascular flaps, anastomosis compromise occurs in 5-10% and that can lead to flap failure. Reliable monitoring of the flap is therefore of similar importance to that of the precise surgical procedure itself. Multiple methods have been reported for monitoring of the flap vitality, the first one being direct visual monitoring. In buried flaps direct visualisation is not feasible or is unreliable. In these cases we can extend the buried flap to expose a segment of it to act as a monitoring sentinel. For the purpose of this review we used our clinical experience as a starting point, and for the extended information and expertise we conducted a search of the PubMed database. Over 40 monitoring techniques have been reported to-date. Direct visual monitoring is still generally used method with a reliability of up to 100% and an overall success rate of up to 99%. Direct visualisation remains as the simplest, cheapest and yet a very reliable method of flap monitoring. In this review we provide a description of various possible techniques for externalising part of a buried flap, define the tissues that can be used for this purpose and we summarise the procedures that should be followed to achieve the best reliability and validity of monitoring the skin island.

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Section: Resultsmentioning

confidence: 99%

The use of sentinel skin islands for monitoring buried and semi-buried micro-vascular flaps. Part II: Clinical application

Molitor¹,

Měšťák²,

Pink³

et al. 2021

BIOMED PAP

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“…Compound muscle action potentials can be used to estimate the amplitude, latency, and duration in muscle flaps to assess muscle functional capacity that decreases in the case of ischemia caused by vascular obstruction. The critical values of amplitude changes for vascular compromise are more than 40% initially and continue decrease thereafter 96 .…”

Section: Brief Description Of Monitoring Methodsmentioning

confidence: 98%

The use of sentinel skin islands for monitoring buried and semi-buried micro-vascular flaps. Part I: Summary and brief description of monitoring methods

Molitor¹,

Měšťák²,

Pink³

et al. 2021

BIOMED PAP

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Micro-vascular flaps have been used for the repair of challenging defects for over 45 years. The risk of failure is reported to be around 5-10% which despite medical and technical advances in recent years remains essentially unchanged. Precise, continuous, sensitive and specific monitoring together with prompt notification of vascular compromise is crucial for the success of the procedure. In this review, we provide a classification and brief description of the reported methods for monitoring the micro-vascular flap and a summary of the benefits over direct visual monitoring. Over 40 different monitoring techniques have been reported but their comparative merits are not always obvious. One looks for early detection of a flap's compromise, improved flap salvage rate and a minimal false-positive or false-negative rate. The cost-effectiveness of any method should also be considered. Direct visualisation of the flap is the method most generally used and still seems to be the simplest, cheapest and most reliable method for flap monitoring. Considering the alternatives, only implantable Doppler ultrasound probes, near infrared spectroscopy and laser Doppler flowmetry have shown any evidence of improved flap salvage rates over direct visual monitoring.

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“…The CMap database is an open access online tool that predicts potential drugs and has been used in this study to screen out potential compounds that can bind to the proteins ( Gillbro et al, 2015 ; Khater et al, 2015 ), of which the expression was altered by cigarette smoking. The match possibility between the chemical substance and the gene inquired was evaluated by connection score ranging from −1 to 1 and p < 0.05 was set as the cutoff value.…”

Section: Methodsmentioning

confidence: 99%

Epigenetic Biomarkers Screening of Non-Coding RNA and DNA Methylation Based on Peripheral Blood Monocytes in Smokers

Huang

Zhang

et al. 2022

Front. Genet.

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This study aims to use bioinformatics methods to determine the epigenetic changes in microRNA expression and DNA methylation caused by cigarette smoking. The data of mRNA, miRNA expression, and methylation microarray were obtained from the GEO database to filter differentially expressed genes (DEGs), differentially expressed miRNAs (DEMs), and methylated CpG probes (DMPs) through the limma package. The R clusterProfile package was used for functional annotation and enrichment analysis. The protein-protein interaction (PPI) network was constructed by the String database and visualized in Cytoscape software. Starbase database was employed to predict lncRNA and CirRNA based on the sequence of miRNA, and to establish a regulatory network of ceRNA. By overlapping DEG and DEM, 107 down-miRNA-targeted up-regulated genes and 65 up-miRNA-target down-regulated genes were obtained, which were mainly enriched in autophagy signaling pathways and protein ubiquitination pathways, respectively. In addition, 324 genes with low methylation and high expression and 204 genes with high methylation and low expression were respectively related to the degeneration of the nervous system and the function of the cardiovascular system. Interestingly, 43 genes were up-regulated under the dual regulation of reduced miRNA and hypomethylation, while 14 genes were down-regulated under the dual regulation of increased miRNA and hypermethylation. Ten chemicals have been identified as putative therapeutic agents for pathological conditions caused by smoking. In addition, among these genes, HSPA4, GRB2, PRKCA, and BCL2L1 could play a fundamental role in related diseases caused by smoking and may be used as the biomarkers for precise diagnosis and targets for future therapies of smoking-related diseases.

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The use of compound muscle action potentials (CMAP) for postoperative monitoring of free functioning gracilis muscle transfer: A preliminary report

Cited by 7 publications

References 21 publications

The use of sentinel skin islands for monitoring buried and semi-buried micro-vascular flaps. Part II: Clinical application

The use of sentinel skin islands for monitoring buried and semi-buried micro-vascular flaps. Part II: Clinical application

The use of sentinel skin islands for monitoring buried and semi-buried micro-vascular flaps. Part I: Summary and brief description of monitoring methods

Epigenetic Biomarkers Screening of Non-Coding RNA and DNA Methylation Based on Peripheral Blood Monocytes in Smokers

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