The use of collagen fleece (TachoSil) as grafting material in the surgical treatment of Peyronie’s disease. A comprehensive narrative review

Sokolakis, Ioannis; Pyrgidis, Nikolaos; Hatzichristodoulou, Georgios

doi:10.1038/s41443-020-00401-8

Cited by 14 publications

(6 citation statements)

References 39 publications

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“…Therefore, there is an urgent need to develop new hemostasis methods to manage clinical bleeding. Topical hemostatic agents, such as gelatin, cellulose, and dressings, have been developed for clinical local hemostasis (Roshkovan et al, 2021;Shah and da Cruz, 2021;Sokolakis et al, 2022). The hemostatic effect of these materials is better than that of traditional gauze, and there is no toxic effect on the surrounding tissue.…”

Section: Results Referencesmentioning

confidence: 99%

Application of chitosan-based materials in surgical or postoperative hemostasis

et al. 2022

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Uncontrolled bleeding from trauma or surgery remains an important factor affecting the survival and prognosis of surgical patients. Failure to timeously stop bleeding will not only prolong the operative time but also threaten the patient’s life. Timely hemostasis after bleeding has become the most concerned event for surgeons. At present, the most commonly used hemostasis methods in the operating room include ligation of blood vessels, electrocautery, and gauze compression to stop bleeding. However, These hemostatic methods do great harm to surrounding tissues while achieving hemostasis. Based on tissue engineering repair strategies, the use of natural polymer materials as hemostatic agents has achieved clinical success. Gelatin sponge and cellulose gauze have been used clinically with good results. However, gelatin sponges are very expensive and place enormous financial pressure on patients. Therefore, there is an urgent need for new hemostatic materials for surgical hemostasis. Chitosan is a natural polysaccharide with biocompatibility and biodegradability, which plays an important role in tissue engineering and regenerative medicine. Chitosan gauze has been proven to have good hemostatic effects. The positive charge on the surface of chitosan can adsorb red blood cells and platelets at the bleeding site to form platelet thrombosis. However, chitosan is not easily soluble in water and has poor adsorption, which makes it a weak local hemostatic agent. Therefore, it is important to improve chitosan-based hemostatic material such that it l has an excellent hemostatic effect. In this review, we introduce the physiological coagulation process and discuss the physicochemical properties of chitosan and its role in hemostasis. Furthermore, we discuss the advantages and disadvantages of chitosan-based hemostatic materials. Finally, we summarize and discuss chitosan-based hemostatic materials.

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Section: Results Referencesmentioning

confidence: 99%

Application of chitosan-based materials in surgical or postoperative hemostasis

et al. 2022

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“…Surgeries using Tachosil ® and its efficacies for other diseases of urology have already been reported. For example, many advantages have been reported in surgery of Peyronie’s disease like self-adhesive properties, decreased operative time, minimal risk of contraction compared to other grafting materials, hemostatic effect, hemostatic effect and cost effect[ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Collagen fleece (Tachosil^®) for treating testis torsion: A case report

Kim¹,

Kim²

2023

World J Clin Cases

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BACKGROUND Testicular torsion is an emergent disease in urology, and there has been discussion of the treatment of testicular torsion. Testicular decompression has been established as a critical treatment for testicular compartment syndrome (TCS), which occurs after detorsion in a patient who is diagnosed with testis torsion. Until now, testicular fasciotomy and incision of tunica albuginea with tunica vaginalis flap (TVF) graft have been suggested for decompression, and some studies about the efficacy of TVF were reported. However, this method is time consuming and needs meticulous technique, so other methods such as orchio-septopexy are suggested. The objective of this clinical case report was to propose new surgical method using collagen fleece (Tachosil ® ) instead of tunica vagina flap. CASE SUMMARY A 5-year-old boy with scrotal pain visited our hospital 24 h after symptom onset. After history taking, physical examination, and scrotum ultrasonography, he was diagnosed with testis torsion. Emergency surgery was performed after diagnosis. Following the incision of scrotum and fasciotomy, we covered his tunica albuginea with collagen fleece called Tachosil ® instead of covering with TVF. CONCLUSION Short-term follow-up showed normal blood flow in testis without a TCS. This is the first case report of using Tachosil ® in testicular torsion surgery, and its advantages were already reported in other surgeries like Peyronie’s disease. Our case suggests this new technique is an appropriate method because of its advantages including its cost-effective and time-saving characteristics. The main limitation is the short follow-up, so more studies are needed to provide a high level of evidence about its efficacy and safety.

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“…Still, there is a tendency to prefer xenografts, such as porcine small intestine submucosa (SIS), bovine pericardium, or collagen eece (CF) [3,6]. Grafting by CF xenograft (TachoSil) is promising for its effectiveness and safety, as well as for its practicality and ease of use, which reduces operating time and costs [3,[6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Collagen Fleece Grafting for Surgical Treatment of Patients with Mild to Severe Peyronie’s Curvatures

Garaz,

Amend,

Stenzl

et al. 2024

Preprint

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Background Collagen Fleece Grafting (CFG) for Peyronie’s Disease (PD) is a recommended treatment option for severe curvature > 60 degrees. However, little is known about its utility in mild curvatures. A subgroup of patients with a significant risk of penile shortening or symptomatic plaques might benefit from the approach in mild curvatures < 60°. We aimed to analyze the treatment indications, surgical technique, and early postoperative results of CGF in this scenario. We performed a retrospective review of patients undergoing surgical treatment for PD using partial plaque excision or incision and CFG. Patients were referred for surgery when the duration of PD was at least 9 months and previous conservative therapies had failed. Clinical parameters and complications were reviewed. Subgroup analysis was performed in patients with curvatures of > 60° and mild curvatures ≤ 60. Results A total of 89 patients were identified. Median (range) age was 59 (38–73) years, and median (range) curvature was 70 (20–90)°. Curvature was dorsal in 66% of cases, ventral in 8%, lateral in 16%, and complex in 10% of cases. Partial plaque excision was performed in 87 (98%) patients. The mean (SD) surface area of grafting was 2.1 (1.9) cm2. The number of penile plaques was only one in 63 (71%) patients and 2 or more in 26 (29%) patients. There was no difference between the two groups (Curvature ≤ 60 vs. >60) regarding mean operation time (86.3 vs. 94.4 min, p = 0.13) or mean hospital stay (5 vs. 5 days, p = 0.77). There was no significant difference between the two groups regarding the incidence of post-operative glans necrosis nor glans hypoesthesia, ecchymosis, bleeding, hematoma, infection, residual curvature, revision surgery, or pain. Conclusions In patients with mild and severe PD deformities, early post-operative outcomes and complications after partial plaque incision or excision and grafting with CFG seemed similar. The technique may be safely applied in select patients with mild penile curvature.

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The use of collagen fleece (TachoSil) as grafting material in the surgical treatment of Peyronie’s disease. A comprehensive narrative review

Cited by 14 publications

References 39 publications

Application of chitosan-based materials in surgical or postoperative hemostasis

Application of chitosan-based materials in surgical or postoperative hemostasis

Collagen fleece (Tachosil^®) for treating testis torsion: A case report

Collagen Fleece Grafting for Surgical Treatment of Patients with Mild to Severe Peyronie’s Curvatures

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The use of collagen fleece (TachoSil) as grafting material in the surgical treatment of Peyronie’s disease. A comprehensive narrative review

Cited by 14 publications

References 39 publications

Application of chitosan-based materials in surgical or postoperative hemostasis

Application of chitosan-based materials in surgical or postoperative hemostasis

Collagen fleece (Tachosil®) for treating testis torsion: A case report

Collagen Fleece Grafting for Surgical Treatment of Patients with Mild to Severe Peyronie’s Curvatures

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Product

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Collagen fleece (Tachosil^®) for treating testis torsion: A case report