The use of chromophore and fluorophore degradation to quantitate UV dose: FD&amp;C dyes as chemical identicators for UV sterilization

Putt, Karson S.; Kernick, Edward R.; Lohse, Brieanna K.; Lomboy, James; O’Brien, Terence J.; Pugh, Randall B.

doi:10.1016/j.mimet.2012.08.015

Cited by 8 publications

(3 citation statements)

References 29 publications

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“…For this reason, the dielectric barrier discharge plasma sterilizing process investigated in this research may produce different species, such as excited nitrogen, rather than the charged particles, such as ions, in low-pressure plasma. Ultraviolet irradiation has been used for the sterilization of medical instruments for well over 60 years [18,19]. The ultraviolet light generated by the plasma may therefore have played an additional role in sterilization.…”

Section: Experimental Methodsmentioning

confidence: 99%

Tribological Properties of Cutting Fluid Sterilized by Atmospheric-Pressure Plasma Treatment

et al. 2018

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Plasma jet sterilization of cutting fluid was performed under atmospheric pressure, and the tribological properties of the resulting fluid were investigated. The mechanisms of atmospheric-pressure plasma jet sterilization were also clarified. The number of bacterial colonies in the sterilized fluid was reduced by more than 90% compared with the untreated fluid. After exposure to ultraviolet light, no comparable reduction was observed. We concluded that the sterilization observed in the study was caused by the reaction of excited N 2 , N, and Ar. The IR spectra of the plasma-treated cutting fluid were the same as those of the untreated fluid. However, the transmittance of the C=O peak decreased in proportion to the discharge voltage. The treated cutting fluids maintained a low friction coefficient 2.4 times longer than the untreated fluid. The sliding angle and adhesive energy of the untreated cutting fluid were considerably lower than those of the unused cutting fluid. Furthermore, the sliding angle and adhesive energy of the plasma-treated cutting fluid were higher than those of the untreated cutting fluid. Therefore, we consider that the lower friction coefficient of plasma-treated cutting fluid as compared to that of the untreated cutting fluid is related to this result. The study demonstrated that the life of a cutting fluid can be prolonged by this novel plasma treatment, with an associated improvement in tribological properties.

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Section: Experimental Methodsmentioning

confidence: 99%

Tribological Properties of Cutting Fluid Sterilized by Atmospheric-Pressure Plasma Treatment

et al. 2018

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“…For this reason, the dielectric barrier discharge plasma sterilization process investigated in the present work may produce species such as excited nitrogen rather than charged particles such as the ions produced in low-pressure plasma. Ultraviolet (UV) irradiation has been used to sterilize medical instruments for more than 60 years (Putt et al, 2012;Zhao et al, 2010). The UV light generated by the plasma may therefore play an additional role in sterilization.…”

Section: Resultsmentioning

confidence: 99%

Quality improvement of deteriorated cutting fluid treated by atmospheric-pressure plasma jet and in-liquid plasma

Miyamoto

Tsuboi

Yoshida

et al. 2020

Mechanical Engineering Letters

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“…The stability of coloring agents is one of quality control in soft gelatin capsule formulation because of their sensitivity to environment and chemicals. As mentioned above, color degradation could lead to color fading (51,52,54). The change in color can be measured by several techniques.…”

Section: Determination Of Color Stability and Color Fadingmentioning

confidence: 99%

Effect of degradation of peg 600 on color fading and crosslinking in soft gelatin capsule shell

Nittayasoot

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?Autoxidation of polyethylene glycol (PEG) 600, which is a hydrophilic liquid commonly filled in soft gelatin capsules, results in formaldehyde which is an oxidizing agent.? The objectives of the present study were to study the effect of formaldehyde on fading of brilliant blue dye and crosslinking in the soft gelatin capsules; also to investigate possibility of inhibition of PEG 600 autoxidation by a selected antioxidant.? Nine PEG 600 based fill formulations were prepared according to a full factorial design with 2 factors and 3 levels of water (0, 5, 10 %w/w) and an antioxidant, i.e. d-?-tocopherol (0, 0.001, 0.05 %w/w). They were encapsulated in non-colored and brilliant blue colored shells.? The capsules were stored in ambler glass bottles under 30oC/75%RH for 90 days. Physicochemical properties of capsules were evaluated. ?The results showed that autoxidation of PEG 600 occurred and initial water content in the formulation had a significant effect on formaldehyde formation analyzed at 14 days (p-value = 0.001).? The maximum level of d-?-tocopherol used in this study could not inhibit PEG 600 autoxidation. Color fading was not visually observed. However, delta E of capsule shells at 90 days was increased from that at first day and the total color content was reduced in some formulations. Brilliant blue in the shell was found to migrate into PEG 600 based liquid fill. ?Moreover, crosslinking of the gelatin shell could be detected by FT-IR spectroscopy and it was confirmed by dissolution results.? Overall, it could be concluded that autoxidation of PEG 600 resulting in formaldehyde which could cause a problem of gelatin cross-linking, rather than fading of brilliant blue dye.

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The use of chromophore and fluorophore degradation to quantitate UV dose: FD&C dyes as chemical identicators for UV sterilization

Cited by 8 publications

References 29 publications

Tribological Properties of Cutting Fluid Sterilized by Atmospheric-Pressure Plasma Treatment

Tribological Properties of Cutting Fluid Sterilized by Atmospheric-Pressure Plasma Treatment

Quality improvement of deteriorated cutting fluid treated by atmospheric-pressure plasma jet and in-liquid plasma

Effect of degradation of peg 600 on color fading and crosslinking in soft gelatin capsule shell

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