The Use of Chorionic Gonadotropin Hormone in the Treatment of Obesity A Double-Blind Study

Frank, Barry W.

doi:10.1093/ajcn/14.3.133

Cited by 20 publications

(4 citation statements)

References 7 publications

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“…Only six of the 14 RCTs used a standard Simeons regimen only [29,31,35,36,37,39]. Only a small minority reported on all four major outcomes (weight-loss, fat-redistribution, hunger, feeling of well-being) [23,31,33,34,38].…”

Section: Resultsmentioning

confidence: 99%

“…Table 2 Methodological item scores of studies on the effectiveness of human chorionic gonadotropin (HCG) in the treatment of obesity by means of the Simeons therapy Shetty [31] Mens [32] Richter [33] Bosch [23] Greenway [34] Asher [35] Craig [36] Richter [33] Miller [37] Frank [38] Lebon [39] Carne [26] Non-RCTs:…”

Section: Resultsmentioning

confidence: 99%

“…[30] + lectures on diet and behaviour twice a week 20 10 neg neg Shetty [31] standard 0 0 neg neg neg neg Mens [32] + daily group sessions 0 0 neg neg Richter [33] 250 iu HCG daily, control group got no 4 4 neg neg neg neg injections, only diet; weekly supporting interview Bosch [23] + lectures on obesity and behaviour once a week 15 20 neg neg neg neg Greenway [34] HCG dose not mentioned 10 35 neg neg neg neg Asher [35] standard 0 0 pos pos 0 10 pos Craig [36] standard 0 0 neg Richter [33] all patients used contraceptives; 250 iu HCG daily, 13 6 neg neg neg neg control group got no injections, only diet; weekly supporting interview Miller [37] standard 0 0 neg neg neg Frank [38] 1030 kcal. daily + 3 times weekly 200 iu HCG subcutaneously 0 0 neg neg neg neg Lebon [39] standard 0 0 pos Carne [26] + daily group sessions, used CG instead of HCG 8 17 neg *HCG = Human chorionic gonadotropin.…”

Section: Resultsmentioning

confidence: 99%

“…A weakness in several studies is that potentially disturbing variables are not recognised as such (criterion G): for instance, when HCG is dissolved it may become less effective under the influence of environmental factors. In several studies the HCG solution was kept for a long time and sometimes there was no mention of the conditions under which it was kept [26,37,38]. In addition, few of the studies mention how much contact there was between the patient and the person administering the treatment (criterion G, see Appendix) or between the patient and other patients receiving the treatment (group sessions) ( Table 3).…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

The effect of human chorionic gonadotropin (HCG) in the treatment of obesity by means of the Simeons therapy: a criteria‐based meta‐analysis.

Lijesen

Theeuwen

Assendelft

et al. 1995

Brit J Clinical Pharma

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1. A meta‐analysis was conducted to assess if there is scientific ground for the use of human chorionic gonadotropin (HCG) as adjunctive therapy in the treatment of obesity. 2. Published papers relating to eight controlled and 16 uncontrolled trials that measured the effect of HCG in the treatment of obesity were traced by computer‐aided search and citation tracking. 3. The trials were scored for the quality of the methods (based on four main categories: study population, interventions, measurement of effect, and data presentation and analysis) and the main conclusion of author(s) with regard to weight‐ loss, fat‐redistribution, hunger, and feeling of well‐being. 4. Methodological scores ranged from 16 to 73 points (maximum score 100), suggesting that most studies were of poor methodological quality. Of the 12 studies scoring 50 or more points, one reported that HCG was a useful adjunct. The studies scoring 50 or more points were all controlled. 5. We conclude that there is no scientific evidence that HCG is effective in the treatment of obesity; it does not bring about weight‐loss of fat‐redistribution, nor does it reduce hunger or induce a feeling of well‐being.

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