The Use of Chemosensitizers to Enhance the Response to Conventional Therapy in Triple-Negative Breast Cancer Patients

Guestini, Fouzia; McNamara, Keely May; Sasano, Hironobu

doi:10.2217/bmt-2017-0030

Cited by 14 publications

(12 citation statements)

References 22 publications

(21 reference statements)

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“…The molecular mechanisms of chemoresistance are drug influx or efflux, DNA damage repair, cell death inhibition, drug inactivation, epithelial-to-mesenchymal transition, drug target alteration, NF-κB and STAT-3 activation [ 15 , 103 ]. Drug efflux, the process through which cancer cells pump chemotherapeutics out of the cells using multidrug resistance proteins, is the most important mechanism [ 15 , 106 ]. Chemosensitization by definition refers to the potentiation of the tumoricidal effect of chemotherapeutic drugs [ 15 ].…”

Section: Natural Compounds As Sensitizers In Drug Resistancementioning

confidence: 99%

“…Chemosensitization by definition refers to the potentiation of the tumoricidal effect of chemotherapeutic drugs [ 15 ]. Therefore, chemosensitizers that are able to accumulate preferably within tumor site and potentialize systemic conventional therapeutic effects could represent potential candidates for fighting drug resistance [ 106 ]. According to previous studies, plant constituents can improve the effectiveness of conventional chemotherapy by increasing the residence time of chemotherapeutics in tumor cells, inducing cell death by up-regulation of pro-apoptotic targets, promoting DNA damage or regulating the expression of altered and unaltered drug targets.…”

Section: Natural Compounds As Sensitizers In Drug Resistancementioning

confidence: 99%

“…These mechanisms enhance the cytotoxic effect of anticancer drugs, promoting a synergistic effect even in the cells with acquired resistance [ 101 , 104 ]. Therefore, they can increase drug efficacy at lower dose levels and thus, reducing its toxicity [ 106 ]. Natural agents such as phenolic derivatives, flavonoids, alkaloids, carotenoids, terpenoids, quinones, saponins and steroids are among the potential chemosensitizers [ 101 , 103 ].…”

Section: Natural Compounds As Sensitizers In Drug Resistancementioning

confidence: 99%

“…Other studies reveal that the association between curcumin and 5-fluorouracil causes synergistic inhibition of growth and induction of potent apoptosis in resistant breast and gastric cancer cell lines in vitro, through NF-κB downregulation, reducing the toxicity of the drug as well [ 106 , 110 ]. Sreekanth et al observed that the combined treatment of curcumin and paclitaxel induced a synergistic reduction in the cervical tumor incidence and volume in animals, compared with the individual treatments of paclitaxel or curcumin [ 111 ].…”

Section: Natural Compounds As Sensitizers In Drug Resistancementioning

confidence: 99%

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Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy

et al. 2021

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Despite the recent advances in the field of chemically synthetized pharmaceutical agents, nature remains the main supplier of bioactive molecules. The research of natural products is a valuable approach for the discovery and development of novel biologically active compounds possessing unique structures and mechanisms of action. Although their use belongs to the traditional treatment regimes, plant-derived compounds still cover a large portion of the current-day pharmaceutical agents. Their medical importance is well recognized in the field of oncology, especially as an alternative to the limitations of conventional chemotherapy (severe side effects and inefficacy due to the occurrence of multi-drug resistance). This review offers a comprehensive perspective of the first blockbuster chemotherapeutic agents of natural origin's (e.g. taxol, vincristine, doxorubicin) mechanism of action using 3D representation. In addition is portrayed the step-by-step evolution from preclinical to clinical evaluation of the most recently studied natural compounds with potent antitumor activity (e.g. resveratrol, curcumin, betulinic acid, etc.) in terms of anticancer mechanisms of action and the possible indications as chemotherapeutic or chemopreventive agents and sensitizers. Finally, this review describes several efficient platforms for the encapsulation and targeted delivery of natural compounds in cancer treatment

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Section: Natural Compounds As Sensitizers In Drug Resistancementioning

confidence: 99%

Section: Natural Compounds As Sensitizers In Drug Resistancementioning

confidence: 99%

Section: Natural Compounds As Sensitizers In Drug Resistancementioning

confidence: 99%

Section: Natural Compounds As Sensitizers In Drug Resistancementioning

confidence: 99%

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Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy

et al. 2021

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“…Additionally, these natural compounds have shown beneficial effects in combination treatments along with classical anticancer drugs [ 350 ]. This strategy improves the efficacy of anticancer treatment, reduces side effects, and sensitizes the resistant phenotype to chemotherapy [ 351 ]. Combinations of phytochemicals such as resveratrol and quercetin [ 266 ], resveratrol and curcumin [ 236 ], and curcumin and quercetin [ 237 ] were more efficient in the treatment of cancers, including breast cancers, when compared to using these compounds alone for therapeutic purposes.…”

Section: Observations Inferences and Concluding Remarksmentioning

confidence: 99%

The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers

Varghese

Samuel

Abotaleb

et al. 2018

Cancers

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Among the different types of breast cancers, triple-negative breast cancers (TNBCs) are highly aggressive, do not respond to conventional hormonal/human epidermal growth factor receptor 2 (HER2)-targeted interventions due to the lack of the respective receptor targets, have chances of early recurrence, metastasize, tend to be more invasive in nature, and develop drug resistance. The global burden of TNBCs is increasing regardless of the number of cytotoxic drugs being introduced into the market each year as they have only moderate efficacy and/or unforeseen side effects. Therefore, the demand for more efficient therapeutic interventions, with reduced side effects, for the treatment of TNBCs is rising. While some plant metabolites/derivatives actually induce the risk of cancers, many plant-derived active principles have gained attention as efficient anticancer agents against TNBCs, with fewer adverse side effects. Here we discuss the possible oncogenic molecular pathways in TNBCs and how the purified plant-derived natural compounds specifically target and modulate the genes and/or proteins involved in these aberrant pathways to exhibit their anticancer potential. We have linked the anticancer potential of plant-derived natural compounds (luteolin, chalcones, piperine, deguelin, quercetin, rutin, fisetin, curcumin, resveratrol, and others) to their ability to target multiple dysregulated signaling pathways (such as the Wnt/β-catenin, Notch, NF-κB, PI3K/Akt/mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK) and Hedgehog) leading to suppression of cell growth, proliferation, migration, inflammation, angiogenesis, epithelial-mesenchymal transition (EMT) and metastasis, and activation of apoptosis in TNBCs. Plant-derived compounds in combination with classical chemotherapeutic agents were more efficient in the treatment of TNBCs, possibly with lesser side effects.

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Impact of Topoisomerase IIα, PTEN, ABCC1/MRP1, and KI67 on triple-negative breast cancer patients treated with neoadjuvant chemotherapy

Guestini

Ono

Miyashita

et al. 2018

Breast Cancer Res Treat

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The Use of Chemosensitizers to Enhance the Response to Conventional Therapy in Triple-Negative Breast Cancer Patients

Cited by 14 publications

References 22 publications

Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy

Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy

The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers

Impact of Topoisomerase IIα, PTEN, ABCC1/MRP1, and KI67 on triple-negative breast cancer patients treated with neoadjuvant chemotherapy

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