The use of chemometrics to study multifunctional indole alkaloids from Psychotria nemorosa (Palicourea comb. nov.). Part II: Indication of peaks related to the inhibition of butyrylcholinesterase and monoamine oxidase-A

Herbal medicines are important options for the treatment of several illnesses. Although their therapeutic applicability has been demonstrated throughout history, several concerns about their safety and efficacy are raised regularly. Quality control of articles of botanical origin, including plant materials, plant extracts, and herbal medicines, remains a challenge. Traditionally, qualitative (e.g., identification and chromatographic profile) and quantitative (e.g., content analyses) markers are applied for this purpose. The compound-oriented approach may stand alone in some cases (e.g., atropine in Atropa belladonna). However, for most plant materials, plant extracts, and herbal medicines, it is not possible to assure quality based only on the content or presence/absence of one (sometimes randomly selected) compound. In this sense, pattern-oriented approaches have been extensively studied, introducing the use of multivariate data analysis on chromatographic/spectroscopic fingerprints. The use of genetic methods for plant material/plant extract authentication has also been proposed. In this study, traditional approaches are reviewed, although the focus is on the applicability of fingerprints for quality control, highlighting the most used approaches, as well as demonstrating their usefulness. The literature review shows that a pattern-oriented approach may be successfully applied to the quality assessment of articles of botanical origin, while also providing directions for a compound-oriented approach and a rational marker selection. These observations indicate that it may be worth considering to include fingerprints and their data analysis in the regulatory framework for herbal medicines concerning quality control since this is the foundation of the holistic view that these complex products demand.

show abstract

“…Therefore, OPLS was considered the best technique to indicate the bioactive compounds. Similar results were observed in other studies [136,137].…”

Section: Fingerprint Approachessupporting

confidence: 93%

“…▶ Fig.3Fingerprints and color maps of their correlation coefficients (at the bottom) before (a) and after (b) warping. Source: Reproduced with permission from[136]. [rerif] Klein-Junior LC et al Quality Control of … Planta Med | © 2021.…”

mentioning

confidence: 99%

Quality Control of Herbal Medicines: From Traditional Techniques to State-of-the-art Approaches

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…The use of chemometrics to study multifunctional indole alkaloids from Psychotria nemorosa (Palicourea comb. nov.) was developed by Júnior et al 3 . The techniques PCA, partial least squares (PLS) and orthogonal PLS1 (O-PLS1) were helpful for modelling the activities using ultra-high-performance liquid chromatographydiode array detector (UPLC-DAD) data as fingerprint 3 .…”

Section: Medical and Pharmaceutical Applicationsmentioning

confidence: 99%

“…nov.) was developed by Júnior et al 3 . The techniques PCA, partial least squares (PLS) and orthogonal PLS1 (O-PLS1) were helpful for modelling the activities using ultra-high-performance liquid chromatographydiode array detector (UPLC-DAD) data as fingerprint 3 . Ultraviolet spectral data from monoclonal antibodies compounded into hospital pharmacy were evaluated to build models using PLS-discriminant analysis (PLS-DA challenge was to identify the monoclonal antibodies after compounding and just before administration to the patient for quality control at the hospital 4 .…”

Section: Medical and Pharmaceutical Applicationsmentioning

confidence: 99%

Chemometrics in analytical chemistry – an overview of applications from 2014 to 2018

et al. 2019

View full text Add to dashboard Cite

A compilation of papers published between 2014 and 2018 was evaluated. Many papers related to multivariate calibration and classification have been reported, as well as, design of experiments applications and artificial intelligence methods. Some applications were highlighted, as medical and pharmaceutical, food analysis, fuels, biological and forensic for the chemometric techniques on this review. Most studies are related to developing methods for practical solutions in industry or routine analysis. A promising scenario is shown considering the number of published papers: a total of 832 for this period using the keywords, multivariate classification, multivariate calibration, analysis, chemometrics, prediction, analytical chemistry, artificial neural networks (ANN), design of experiments (DoE) and factorial design. An useful overview for Analytical Chemistry researchers´ combined with Chemometrics is presented in this review.

show abstract

“…acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase A (MAO-A), MAO-B, and catechol-O-methyltransferase (COMT) has been demonstrated. [4][5][6][7][8][9][10][11][12][13] In this sense, Psychotria is considered as an important source of active compounds…”

mentioning

confidence: 99%

Bioactive Azepine-Indole Alkaloids from Psychotria nemorosa

et al. 2020

Self Cite

View full text Add to dashboard Cite

Phytochemical investigation of the alkaloid extract of the aerial parts ofPsychotria nemorosa led to the isolation and characterization of 10 azepine-indole alkaloids, i.e., cimitrypazepine (1), fargesine (2), nemorosines A (3) and B (12), nemorosinosides A-F (4-9), as well as two β-carboline derivatives, 10hydroxyisodolichantoside (10) and 10-hydroxydolichantoside (11), an isoxazole alkaloid, nemorosinoside G (13), serotonin (14), bufotenine (15), and (S)-gentianol ( 16).Compounds 3-13 have not yet been described. These compounds were isolated by semipreparative HPLC and their structures determined by means of HRMS, NMR, and ECD measurements. In addition, the monoamine oxidase-A (MAO-A), MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitory activities were evaluated. Alkaloids 1-3 inhibited the MAO-A activity with IC50 values of 1.4, 1.4, and 0.9 µM, respectively. 3The genus Psychotria, a member of the Rubiaceae family, has been widely studied because of its effects on the central nervous system (CNS). Some species of the genus, like P. viridis, are used to prepare Ayahuasca, a hallucinogenic beverage consumed by Amazon Indian tribes. 1 Recently, this preparation has attracted the attention of researchers due to its pharmacological potential, mainly to treat depression. [1][2][3] Other species have been described to treat dementia, which is corroborated by pharmacological studies. Their capacity to modulate key enzymes related to neurodegeneration, e.g. acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase A (MAO-A), MAO-B, and catechol-O-methyltransferase (COMT) has been demonstrated. [4][5][6][7][8][9][10][11][12][13] In this sense, Psychotria is considered as an important source of active compounds

show abstract

The use of chemometrics to study multifunctional indole alkaloids from Psychotria nemorosa (Palicourea comb. nov.). Part II: Indication of peaks related to the inhibition of butyrylcholinesterase and monoamine oxidase-A

Cited by 19 publications

References 36 publications

Quality Control of Herbal Medicines: From Traditional Techniques to State-of-the-art Approaches

Quality Control of Herbal Medicines: From Traditional Techniques to State-of-the-art Approaches

Chemometrics in analytical chemistry – an overview of applications from 2014 to 2018

Bioactive Azepine-Indole Alkaloids from Psychotria nemorosa

Contact Info

Product

Resources

About