The use of chemical probes for the characterization of solvent mixtures. Part 2. Aqueous mixtures

Marcus, Yizhak

doi:10.1039/p29940001751

Cited by 163 publications

(147 citation statements)

References 35 publications

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“…However, linear relationships between log k and E~ parameter show two straight lines with different slopes which intersect at an acetonitrile percentage about 20 % (Figure 2). This behaviour is probably due to the structural features of acetonitrile-water mixtures [20,37] and to preferential solvation [38,39]. On the water-rich side, when XAN 0.10, water structure remains more or less intact and the acetonitrile molecules occupy the cavities between the water structures wit little disruption.…”

Section: Resultsmentioning

confidence: 91%

Prediction of the chromatographic behaviour for a series of diuretic compounds

2000

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SummaryThe proportion of organic modifier and the pH of the acetonitrile-water mixtures used as mobile phases were optimized in order to separate a group of diuretic compounds covering a wide range of physyco-chemical properties. The Linear Solvation Energy Relationship (LSER) formalism based either on the multiparameter re*,/3 and ce scales or the single solvent polarity parameter E7 N, have been used to predict their chromatographic behaviour as a function of the percentage of acetonitrile in the eluent. Moreover, correlation established between retention and pH of the aqueous-organic mobile phases have been used to predict the chromatographic behaviour of the diuretic compounds studied as a function of the eluent pH. Linear correlation between the chromatographic retention and the E~ polarity parameter of mobile phases containing different percentages of organic modifier has been obtained. Based on the knowledge of the acid-base dissociation constant the relation between retention and mobile phase pH has also been linearized. These relationships allowed an important reduction of the experimental retention data needed for developing a given separation and a great improvement in chromatographic optimization schemes.

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Section: Resultsmentioning

confidence: 91%

Prediction of the chromatographic behaviour for a series of diuretic compounds

2000

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“…Here we use M in order to avoid any confusion with the modulus of the molecular dipole moment. We present in Table 2d the values of M taken from two papers by this author, [80,81]. They have been carefully checked against a list he kindly provided to us.…”

mentioning

confidence: 99%

Critical compilation of scales of solvent parameters. Part I. Pure, non-hydrogen bond donor solvents

Abboud¹,

Notari²

1999

Pure and Applied Chemistry

395

286

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Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without the need for formal IUPAC permission on condition that an acknowledgement, with full reference to the source along with use of the copyright symbol ᭧, the name IUPAC and the year of publication are prominently visible. Publication of a translation into another language is subject to the additional condition of prior approval from the relevant IUPAC National Adhering Organization.

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“…Retention factors were calculated using the normal MEKC equation, where methanol and anthracene were used as the EOF and the micelle migration marker, respectively. Average effective hydrogen bond acidity (A), average effective hydrogen bond basicity (B), and dipolarity/polarizability parameter (S) for the pure solvents and water-ACN, water-EtOH, and water-THF mixtures were obtained from the literature [61,62] and pondered by the volume proportion of solvent in the medium. This approximation holds linear within the low organic solvent percentage range used in this work.…”

Section: Solvent Effectsmentioning

confidence: 99%

“…4 results imply, the micellar phase properties do not need to be described and an LSER with the electrolyte parameters only could be undertaken. By calculating the parameters A, B, S [61,62], dielectric constant (e) [67], refractive index (Z D ) [68,69], and the Hildebrand solubility parameter (d) [70] for six binary electrolyte systems, the triple point and the aqueous electrolyte, and by using the experimental retention data of the seven steroids of series II, a system LSER approach was conducted. The four estrogens of series I were excluded from the calculations because at the electrolyte pH they are partially ionized and pK a data were not available to account for their fractional migration as anions.…”

Section: Solvent Effectsmentioning

confidence: 99%

Mixture‐designed electrolytes for the MEKC separation of natural and synthetic steroids

et al. 2007

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In this work, the separation of 11 natural and synthetic steroids was studied using MEKC electrolytes modified by property-selected organic solvents: ethanol, ACN, and THF. The interplay between electrophoretic behavior and structural features was disclosed and the effects of organic modifiers to modulate retention and to alter selectivity were discussed in terms of system linear solvation energy relationships (LSER). The LSER indicated the total organic solvent percentage in the electrolyte as a major parameter to control retention and as a minor contribution, the hydrogen bond acidity. By evaluating the electropherograms obtained from mixture-designed electrolytes, a favorable separation condition for all solutes was achieved in ca. 25 min with an electrolyte composed of 20 mmol/L sodium tetraborate at pH 9.4, 20 mmol/L SDS and 20% EtOH (0.80% CV for migration time and 2.5% CV for peak area, n = five consecutive injections). The applicability of the proposed separation condition was demonstrated by the inspection of estrogens in urine sample (puberty stage).

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The use of chemical probes for the characterization of solvent mixtures. Part 2. Aqueous mixtures

Cited by 163 publications

References 35 publications

Prediction of the chromatographic behaviour for a series of diuretic compounds

Prediction of the chromatographic behaviour for a series of diuretic compounds

Critical compilation of scales of solvent parameters. Part I. Pure, non-hydrogen bond donor solvents

Mixture‐designed electrolytes for the MEKC separation of natural and synthetic steroids

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