The use of carrageenan in mixture with microcrystalline cellulose and its functionality for making tablets

Picker, Katharina M.

doi:10.1016/s0939-6411(99)00009-0

Cited by 47 publications

(23 citation statements)

References 25 publications

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“…CARRs were also combined with other well-established excipients for controlled release, such as cellulose ethers, to additionally prolong drug release (Nerurkar et al, 2005). Combinations of different CARRs themselves (Gupta et al, 2001) or with inert excipients (Picker, 1999a) were also studied. These investigations have shown that CARRs may interact with some basic drugs (Hugerth, 2001), which can lead to additional decreases in the drug release rate (Hariharan et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Matrix tablets based on carrageenans with dual controlled release of doxazosin mesylate

Pavli

Vrečer

Baumgartner

2010

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Matrix tablets based on carrageenans with dual controlled release of doxazosin mesylate

Pavli

Vrečer

Baumgartner

2010

International Journal of Pharmaceutics

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“…In addition to this, carr reacts as an elastic component, which increases the expansion ability of the tablets. As mentioned in Picker [19], both materials are fibrous bio-polymers but have different structures. Carr is an amorphous polymer and absorbs much more water than mcc.…”

Section: Methodsmentioning

confidence: 99%

“…Research on binders and their functionality in making tablets has been reported by Picker [19], who described that mcc generally reacts like a dry binder in tablets, improving their stability. In addition to this, carr reacts as an elastic component, which increases the expansion ability of the tablets.…”

Section: Methodsmentioning

confidence: 99%

Effects of Feed Powder Quantity and Compression Pressure on the Tensile Strength of Eurycoma longifolia Jack Tablets Using Different Binders

Hamid

Yusof

Chin

et al. 2013

International Journal of Food Engineering

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This study investigated the direct compression properties of Eurycoma longifolia Jack tablets using binary mixtures such as microcrystalline cellulose (mcc) and κ-carrageenan (carr). The mixtures were compacted to various compression pressures ranging from 7.5 to 74 MPa at a constant compression speed of 5 mm/min. The tensile strengths of the tablets were determined by a diametral compression test. A linear relationship between the tensile strength and the compression pressure was observed under the conditions of the test; hence, the slopes of the data were obtained by fitting linear trend lines. This paper shows that binary mixtures of 30% mcc and 70% Eurycoma longifolia Jack give the highest values for constant (a slope) compared with the other binary mixtures of both binders. Thus, this approach can be used to develop formulations for Eurycoma longifolia Jack tablets.

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“…The powders that have been received were sieved and only powders containing particles with sizes below 125 mm were used for tabletting (Picker 1999). 0.5 g of the sieved powders was then compacted inside a 13 mm stainless steel cylindrical uniaxial die (Specac, St. Mary Cray, UK).…”

Section: Preparationmentioning

confidence: 99%

Compaction of Sweet Potato (Ipomoea batatasL.) and Stevia Rebaudiana Food Powders

Shamsudin

Anuar

Tahir

2012

Particulate Science and Technology

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This study has been conducted to evaluate the suitability of sweet potato and Stevia powders as tablets in terms of their compaction behavior and mechanical strength in comparison to an established pharmaceutical binder; microcrystalline cellulose. The results indicated that the behavior of the material during compression, namely, the plastic and elastic deformations influences the final tablet mechanical strength. Relatively high plastic deformation of a material during compression enhances the contact area for interparticulate bonding, thus, producing a mechanically strong tablet. It was observed that the compaction of stevia powder produces a mechanically stronger tablet in comparison to the sweet potato tablet.

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The use of carrageenan in mixture with microcrystalline cellulose and its functionality for making tablets

Cited by 47 publications

References 25 publications

Matrix tablets based on carrageenans with dual controlled release of doxazosin mesylate

Matrix tablets based on carrageenans with dual controlled release of doxazosin mesylate

Effects of Feed Powder Quantity and Compression Pressure on the Tensile Strength of Eurycoma longifolia Jack Tablets Using Different Binders

Compaction of Sweet Potato (Ipomoea batatasL.) and Stevia Rebaudiana Food Powders

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