The use of carbon nanoparticles to track occult lingual lymph nodes in early-stage tongue squamous cell carcinoma

Wu, Wenjie; Zheng, Luming; Zhang, J.-G.

doi:10.1016/j.ijom.2019.02.010

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…The results of several studies con rm a pronounced negative impact on overall survival and recurrence-free survival with up to an 8-fold decrease in prognosis [5,6,7,44,94]. As LLN lesions are often overlooked, it was postulated that every tongue and mouth oor cancer patient should be investigated for LLN existence and possible metastatic involvement by palpation, imaging or special dye tracing techniques preoperatively, intraoperatively and postoperatively [27,32,36,37].…”

Section: Historical Outlinementioning

confidence: 99%

Surgical anatomy of the lingual lymph nodes: systematic literature analysis and proposition for topographic classification

et al. 2023

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Purpose:Metastatic involvement of the lingual lymph nodes (LLNs) in oral cavity squamous cell cancer has recently been proven to signi cantly reduce locoregional control and survival. Despite recent re nements in the detection of these lesions, the understanding of the LLN topographic anatomy among clinicians is limited. A proposition of a topographic division on LLN based on a comprehensive literature search and synthesis may be helpful in this condition.Methods:A literature search and election based on contemporary PRISMA guidelines was performed for sources on LLN anatomy with special attention on their subdivision.Results:Four topographic LLN subgroups were de ned: median -between genioglossal and geniohyoid muscles; intermediate para-hyoid -medial to the hyoglossal muscle, at the greater cornu of the hyoid bone; lateral sublingual (paraglandular) LLNs -at the sublingual salivary gland; lateral submandibular (paraglandular) LLNs -lateral to the hyoglossal muscle, at the deep surface of the submandibular salivary gland. Conclusion:The development and implementation of a uni ed anatomical topographic classi cation of LLN subgroups may be among the important conditions for improving the detection and treatment of LLN lesions.

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Section: Historical Outlinementioning

confidence: 99%

Surgical anatomy of the lingual lymph nodes: systematic literature analysis and proposition for topographic classification

et al. 2023

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“…Other NPs can be used with similar aims: carbon NPs were able to track occult lingual lymph nodes in early-stage tongue squamous cell carcinoma with accuracy [ 258 ]; AgNPs were used as a substrate for SERS, which showed specificity and sensitivity above 90% [ 259 ]; nanostructured zirconia on reduced graphene oxide exhibited a wide linear detection range, excellent sensitivity, and a remarkable low detection limit when used as an immunosensor [ 260 ]; a SERS substrate was made up of leaf-like titanium oxide nanostructures decorated with AgNPs and presented rapid and accurate detection of solid tumors [ 261 ]; and nanostructured yttrium oxide was used for the fabrication of a biosensing platform, which showed a high linear range and remarkable sensitivity [ 262 ].…”

Section: Head Neck and Oral Cancermentioning

confidence: 99%

Nanoparticles in Dentistry: A Comprehensive Review

2021

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In recent years, nanoparticles (NPs) have been receiving more attention in dentistry. Their advantageous physicochemical and biological properties can improve the diagnosis, prevention, and treatment of numerous oral diseases, including dental caries, periodontal diseases, pulp and periapical lesions, oral candidiasis, denture stomatitis, hyposalivation, and head, neck, and oral cancer. NPs can also enhance the mechanical and microbiological properties of dental prostheses and implants and can be used to improve drug delivery through the oral mucosa. This paper reviewed studies from 2015 to 2020 and summarized the potential applications of different types of NPs in the many fields of dentistry.

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“…They noticed two LLNs, which were accepted as sentinel lymph nodes, and stated that LLN may be readily identified in 3D with this technique. This suggests that special lymphographic tracing techniques, which are used for sentinel lymph node mapping and biopsy, may be useful in the pre- or intraoperative identification of LLNs[ 44 , 45 ].…”

Section: Clinical Experiencementioning

confidence: 99%

Lingual lymph nodes: Anatomy, clinical considerations, and oncological significance

Gvetadze

Илькаев

2020

WJCO

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Lingual lymph nodes are an inconstant group of in-transit nodes, which are located on the route of lymph drainage from the tongue mucosa to the regional nodes in neck levels I and II. There is growing academic data on the metastatic spread of oral cancer, particularly regarding the spreading of oral tongue squamous cell carcinoma to lingual nodes. These nodes are not currently included in diagnostic and treatment protocols for oral tongue cancer. Combined information on surgical anatomy, clinical observations, means of detection, and prognostic value is presented. Anatomically obtained incidence of lingual nodes ranges from 8.6% to 30.2%. Incidence of lingual lymph node metastasis ranges from 1.3% to 17.1%. It is clear that lymph nodes that bear intervening tissues from the floor of the mouth should be removed to improve loco-regional control. Extended resection volume, which is required for the surgical treatment of lingual node metastasis, cannot be implied to every tongue cancer patient. As these lesions significantly influence prognosis, special efforts of their detection must be made. Reasonably, every tongue cancer patient must be investigated for the existence of lingual lymph node metastasis. Lymphographic tracing methods, which are currently implied for sentinel lymph node biopsies, may improve the detection of lingual lymph nodes.

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The use of carbon nanoparticles to track occult lingual lymph nodes in early-stage tongue squamous cell carcinoma

Cited by 5 publications

References 9 publications

Surgical anatomy of the lingual lymph nodes: systematic literature analysis and proposition for topographic classification

Surgical anatomy of the lingual lymph nodes: systematic literature analysis and proposition for topographic classification

Nanoparticles in Dentistry: A Comprehensive Review

Lingual lymph nodes: Anatomy, clinical considerations, and oncological significance

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