The use of Bruch's membrane opening-based optical coherence tomography of the optic nerve head for glaucoma detection in microdiscs

Abstract

In small optic discs, BMO-MRW and peripapillary RNFLT (OCT) have similar sensitivity to discriminate patients with glaucoma from normal controls; both exceed CSLT rim area in diagnostic power. In glaucomatous patients, BMO-MRW correlates strongest with visual field function.

Diagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocol

“…Previous studies have shown the clinical utility of BMO-MRW parameters in diagnosing glaucoma, especially in cases of extreme optic-disc sample size, demonstrating better diagnostic capability than confocal scanning laser tomography and exhibiting a good structure function correlation [9,21]. In general, many studies have shown the SD-OCT BMO-MRW and pRNFL thickness parameters to surpass confocal scanning laser tomography as regards diagnostic capacity to detect glaucoma [3,5,18,20,22].…”

“…Recent studies have demonstrated higher glaucoma diagnosis accuracy using BMO-MRW and a stronger association with functional parameters compared to conventional rim parameters [5][6][7]. Various authors have indicated the utility of BMO-MRW in diagnosing glaucoma in moderate myopic eyes [8] or small optic discs [9]. BMO-MRW also showed high intraday repeatability, similar to the RNFL thickness parameters, and independence from intraindividual intraocular pressure (IOP) changes [10].…”

Evaluation of two‐dimensional Bruch's membrane opening minimum rim area for glaucoma diagnostics in a large patient cohort

“…In another study on 207 individuals, BMO‐MRA has also been shown to equalize differences in rim width between healthy small and large optic nerve heads (ONHs) and to have higher diagnostic power for glaucoma compared to conventional parameters (Enders et al. ,b,c).…”

“…Morphometric data for eyes with non‐glaucomatous macrodiscs has been published (Enders et al. ,b,c). Other less frequent ONH configurations (e.g.…”

Intraday Repeatability of Bruch's Membrane Opening-Based Neuroretinal Rim Measurements

“…1,[4][5][6][7][8][9][10][11] Correlation of morphometric parameters of the ONH and visual field function has been evaluated in several studies. 1,[12][13][14][15][16][17][18][19][20][21][22] In addition to the clinically available parameters Bruch's membrane opening-based minimal rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness, two studies on the two dimensional parameter Bruch's membrane opening minimal rim area (BMO-MRA) showed high diagnostic power for all ONH sizes and equalized differences in BMO-MRW between very large and very small ONHs. 1,23 As follow-up data become available, first studies were conducted to assess the performance of SD-OCT for detection of progression of glaucomatous damage to the ONH.…”