The use of botulinum toxin for pediatric cricopharyngeal achalasia

Barnes, Melynda; Ho, Allen S.; Malhotra, Prashant S.; Koltai, Peter J.; Messner, Anna H.

doi:10.1016/j.ijporl.2011.07.022

Cited by 26 publications

(26 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, patients with severe cardiopulmonary dysfunction and impaired blood clotting function were exempted from the study. Likewise, patients with serious erosion or fibrosis in lower segment of esophagus or severe sigmoid-shaped esophagus were excluded [4, 9]. …”

Section: Methodsmentioning

confidence: 99%

Clinical Outcomes and Safety of Partial Full-Thickness Myotomy versus Circular Muscle Myotomy in Peroral Endoscopic Myotomy for Achalasia Patients

Gong

Zhang

et al. 2017

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Background. Here we aimed to evaluate and compare the efficacy and safety between partial full-thickness myotomy and circular muscle myotomy during POEM procedure in achalasia patients. Methods. Clinical data of achalasia of cardia (AC) patients who underwent POEM in our center during January 2014 to January 2015 was collected (34 cases). 19 patients who received partial full-thickness myotomy were assigned to group A and 14 patients who received circular muscle myotomy were assigned to group B. The procedure-related parameters between the two groups were compared. Symptom relief rate and postprocedure manometry outcomes were compared to evaluate the efficacy. Procedure-related adverse events and complications were compared to evaluate the safety. Results. (1) Mean operation times were significantly shorter in group A than group B (62.42 ± 23.17 vs 87.86 ± 26.44 min, p < 0.01). (2) Symptom relief rate and postprocedure manometry outcomes had no statistical differences when compared between the two groups (all p > 0.05). (3) Comparison of procedure-related adverse events and complications had no statistical differences (all p > 0.05). Conclusion. Partial full-thickness myotomy had no significant differences in efficacy or safety with circular myotomy, but partial full-thickness myotomy significantly reduced the procedure time.

show abstract

Section: Methodsmentioning

confidence: 99%

Clinical Outcomes and Safety of Partial Full-Thickness Myotomy versus Circular Muscle Myotomy in Peroral Endoscopic Myotomy for Achalasia Patients

Gong

Zhang

et al. 2017

Gastroenterology Research and Practice

View full text Add to dashboard Cite

show abstract

“…BTI is reported to be beneficial in preventing aspiration and relief of dysphagia. 1,10 The possible complications are leakage of botulinum toxin to adjacent tissues, improper injection affecting vocal cords which can worsen swallowing. 10 The patient had relief of symptoms after BTI but recurrence was seen 2 months later.…”

Section: Discussionmentioning

confidence: 99%

“…1,10 The possible complications are leakage of botulinum toxin to adjacent tissues, improper injection affecting vocal cords which can worsen swallowing. 10 The patient had relief of symptoms after BTI but recurrence was seen 2 months later. Although there are several reports revealing beneficial effects of dilatation and BTI, we could not achieve such a success in the present case.…”

Section: Discussionmentioning

confidence: 99%

Assessment of pediatric cricopharyngeal achalasia with high resolution manometry

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Endoscopy may show a narrowing at the level of the UES and may be helpful to rule out other organic causes (tumors, reflux esophagitis, eosinophilic esophagitis with stenosis). Radiographically, cricopharyngeal achalasia is characterized by a horizontal indentation on the posterior esophageal wall, with the contrast passing the muscle very slowly and the cricopharyngeal muscle appearing to relax poorly (1,3,7,8). Esophageal manometry may be useful and can provide information on the resting tone and relaxation of the UES (2,3,7,8).…”

Section: Discussionmentioning

confidence: 99%

“…Several treatment modalities are available, such as dilatation, local infiltration with botulinum toxin, and surgical myo-tomy of the muscle, performed either endoscopically with laser or through an open transcervical approach (5,8). The long-term success of dilatation as a treatment for cricopharyngeal achalasia has been detailed in several reports (4,7,9).…”

Section: Discussionmentioning

confidence: 99%

Cricopharyngeal achalasia in connection with autoimmune disorders in a pre-adolescent patient: a case report

2017

View full text Add to dashboard Cite

Cricopharyngeal achalasia is an uncommon cause of dysphagia, especially in children. Congenital form is known in neonates and infants. In older children this disease has been reported in very rare cases and mostly in connection with neurological and muscular diseases. We present a case of a 12-year-old girl with a four-year history of dysphagia. Esophagogastroduodenoscopy, radiological contrast swallow study and esophageal manometric study confirmed the diagnosis of cricopharyngeal achalasia. The patient was successfully treated with dilatation of the upper esophageal sphincter. An initial attempt of dilatation appears to be a safe and effective option in the management of cricopharyngeal achalasia in children, and may prevent or at least postpone the need for myotomy. Following the diagnosis of cricopharyngeal achalasia, several autoimmune conditions were diagnosed. Our case report revealed that cricopharyngeal achalasia may occur in association with some other autoimmune conditions, and that autoimmunity may also play a role in cricopharyngeal achalasia itself. IzvlečekKrikofaringealna ahalazija je pri otrocih izjemno redek razlog za disfagijo. Poznana je kongenitalna oblika krikofaringealne ahalazije pri novorojenčkih in dojenčkih, pri starejših otrocih pa so to bolezen doslej opisali zelo redko in večinoma v povezavi z nevrološkimi in mišičnimi boleznimi. V prispevku prikazujemo primer 12-letne deklice s štiriletno anamnezo disfagije. Z ezofagogastroduodenoskopijo, radiološko preiskavo požiranja s kontrastom in ezofagealno manometrijo smo potrdili diagnozo krikofaringealna ahalazija. Bolnico smo uspešno zdravili z dilatacijo zgornjega ezofagealnega ustja. Začetni poizkus zdravljenja z dilatacijo se zdi varna in učinkovita metoda zdravljenja krikofaringelane ahalazije pri otrocih in lahko prepreči ali vsaj odloži potrebo po miotomiji. Po postavitvi diagnoze krikofaringealna ahalazija smo pri bolnici diagnosticirali več avtoimunskih motenj. Opisan primer prikazuje povezavo pojava krikofaringelane ahalazije z avtoimunskim dogajanjem in možnost, da bi lahko bil tudi avtoimunski proces eden od razlogov za pojav krikofaringealne ahalazije.

show abstract

The use of botulinum toxin for pediatric cricopharyngeal achalasia

Cited by 26 publications

References 14 publications

Clinical Outcomes and Safety of Partial Full-Thickness Myotomy versus Circular Muscle Myotomy in Peroral Endoscopic Myotomy for Achalasia Patients

Clinical Outcomes and Safety of Partial Full-Thickness Myotomy versus Circular Muscle Myotomy in Peroral Endoscopic Myotomy for Achalasia Patients

Assessment of pediatric cricopharyngeal achalasia with high resolution manometry

Cricopharyngeal achalasia in connection with autoimmune disorders in a pre-adolescent patient: a case report

Contact Info

Product

Resources

About