The use of BirA-BAP system to study the effect of US2 and US11 on MHC class I heavy chain in cells

Gauthami, S.; Kumar, Deepak; Sivasai, K. S. R.; Hegde, Nagendra R.

doi:10.1016/j.imlet.2017.08.027

Cited by 2 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Suppresses MHC I-restricted recognition [451]; Degrades MHC-I, induce class I heavy chain destruction [474][475][476][477][478]; Escapes CD8+ T-cell immunity by degrading HLA-A and manipulating the HLA-B [479] Immune evasion [451,[474][475][476][477][478][479] US12 NK cell evasion [480]; Induces autophagy via upregulating ULK1 phosphorylation and LC3-II conversion [481] Immune evasion [480] Induces autophagy [481]…”

Section: Us11mentioning

confidence: 99%

Insights into the Transcriptome of Human Cytomegalovirus: A Comprehensive Review

Zeng

Cao

Yang

et al. 2023

Viruses

View full text Add to dashboard Cite

Human cytomegalovirus (HCMV) is a widespread pathogen that poses significant risks to immunocompromised individuals. Its genome spans over 230 kbp and potentially encodes over 200 open-reading frames. The HCMV transcriptome consists of various types of RNAs, including messenger RNAs (mRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs), with emerging insights into their biological functions. HCMV mRNAs are involved in crucial viral processes, such as viral replication, transcription, and translation regulation, as well as immune modulation and other effects on host cells. Additionally, four lncRNAs (RNA1.2, RNA2.7, RNA4.9, and RNA5.0) have been identified in HCMV, which play important roles in lytic replication like bypassing acute antiviral responses, promoting cell movement and viral spread, and maintaining HCMV latency. CircRNAs have gained attention for their important and diverse biological functions, including association with different diseases, acting as microRNA sponges, regulating parental gene expression, and serving as translation templates. Remarkably, HCMV encodes miRNAs which play critical roles in silencing human genes and other functions. This review gives an overview of human cytomegalovirus and current research on the HCMV transcriptome during lytic and latent infection.

show abstract