The use of biological laboratory markers in the diagnosis of alcohol misuse: an evidence-based approach

Carbohydrate-deficient transferrin (CDT) as a marker of alcohol abuse: A critical review of the literature 2001–2005

“…The equation proposed by Sillanaukee and Olsson [56] has been also verified by Anttila et al [58], who, in the assessment of 65 alcoholics, achieved a diagnostic sensitivity of 94% for men and 82% for women. On the other hand, Schwan et al [59], on the basis of a 6-month longitudinal multicenter trial on four different study groups (alcohol abusers, alcohol dependents, healthy controls and consulting controls), recommend the use of CDT as a "first line" biological marker and GGT as a support for differential diagnosis between alcohol abuse and alcohol dependence in patients with high CDT.…”

The alcohol withdrawal syndrome

“…Gamma glutamyl transferase (GGT)38 and carbohydrate-deficient transferrin39 are both sensitive markers for alcohol overuse, particularly when tested as a combination 40. In addition, GGT is relatively non-specific and is frequently elevated in patients taking hepatic enzyme-inducing medications, such as phenytoin and carbamazepine.…”

DOVER and QUVER—New Marker Combinations to Detect and Monitor At‐risk Drinking

“…Further analysis of this data should not only examine the different cutoff points for the AUDIT in subgroups but also allude to the recently pointed important approaches of Schwan et al (2004) on sequencing markers by use of a decision tree analysis. We plan to cross-validate our regression-based results by of contrasting them with the decision-tree model.…”