The use of autologous PRP gel as an aid in the management of acute trauma wounds

Kazakos, Konstantinos; Lyras, Dimitrios N; Verettas, D.; Tilkeridis, Konstantinos; Tryfonidis, M.

doi:10.1016/j.injury.2008.05.002

Cited by 132 publications

(127 citation statements)

References 24 publications

Supporting

Mentioning

115

Contrasting

Unclassified

Order By: Relevance

“…Although the efficacy of PRP has been investigated in wound healing [12][13][14][15] , its effects on TMP healing have not yet been investigated in acute TMPs. In the literature, the only study on the effect of PRP on TMP closure is that reported by El-Anwar et al [16] , wherein they studied 64 patients with chronic TMPs who had undergone postauricular myringoplasty with underlay graft using conchal perichondrial graft.…”

Section: Discussionmentioning

confidence: 99%

“…There have been human studies to report that PRP has a positive effect on wound healing [12][13][14][15] . In animal studies, histological examinations revealed enhanced fibroblastic and endothelial cell formation during wound healing, increased neovascularization [12,[19][20][21][22] , and enhanced granulation tissue formation [12,19,21,22] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Platelet-Rich Plasma Application for Acute Tympanic Membrane Perforations

Özgürsoy

Tunçkaşık²,

Tunçkaşık³

et al. 2017

Int Adv Otol

View full text Add to dashboard Cite

OBJECTIVE:To assess the efficacy of the application of platelet-rich plasma (PRP) in the healing process of acute tympanic membrane perforations (TMPs). MATERIALS and METHODS:Acute TMPs were made in both the ears of 12 New Zealand rabbits. Plasma gel was applied at the right tympanic membrane (TM) of the same animal until the perforations were closed. The left TM was left untreated. On days 1, 4, 7, 10, 13, 16, 21, 28, and 35, the TMs were monitored to check the closure of perforations. The days of perforation closure for the 2 groups were compared using the paired t-test. The animals were sacrificed 2 months after making the perforations. Seven histopathological parameters were reviewed by 2 blinded pathologists: acute inflammation, chronic inflammation, edema in the lamina propria, congestion in the lamina propria, sclerosis, fibroblastic reaction, and an increase in the thickness of the squamous epithelial layer. The presence or absence of each histological parameter in both groups was compared using the Pearson Chi-square test. RESULTS:The average number of days for closure in the plasma gel group was 12 (range 8-18 days) and that in the control group was 17.7 (range 8-31 days). The difference was statistically significant (p=0.0145). There was no sclerosis or fibroblastic reaction in any of the specimens. No statistically significant difference was seen between the 2 groups with respect to acute inflammation, chronic inflammation, edema in the lamina propria, congestion in the lamina propria, and an increase in thickness of the squamous epithelial layer (p>0.05). CONCLUSION:Platelet-rich plasma fastens TMP closure; in long term, the eventual outcome is both microscopically and macroscopically same for the control as well as study groups in a rabbit traumatic TMP model. We believe that this study will encourage the clinical use of PRP for acute TMPs and trigger clinical studies in this field.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Platelet-Rich Plasma Application for Acute Tympanic Membrane Perforations

Özgürsoy

Tunçkaşık²,

Tunçkaşık³

et al. 2017

Int Adv Otol

View full text Add to dashboard Cite

show abstract

“…Kazakos et al compared the use of platelet rich plasma versus conventional therapy in 59 patients suffering from acute trauma wounds. And reported a beneficial effect on wound size reduction and pain perception over a three week period (Kazakos, Lyras et al 2009). Steed et al (1992) performed a randomised controlled trial in 13 diabetic foot patients and observed, over a period of 15 weeks, increased healing in the platelet rich plasma group (Steed, Goslen et al 1992).…”

Section: Platelet Rich Plasma Therapymentioning

confidence: 99%

Heparan Sulfate Proteoglycan Mimetics Promote Tissue Regeneration: An Overview

Neck¹,

Tuk²,

Barritault³

et al. 2012

Tissue Regeneration - From Basic Biology to Clinical Application

View full text Add to dashboard Cite

“…They release epidermal growth factor which promotes endothelial cell proliferations [13]. Recently biologics such as Platelet Rich Plasma gels are also used in the form of local dressing for such wounds [14][15][16][17][18]. This is based on biotechnologically modulating the environment towards the regeneration by PRP led cellular therapy in the wounds [18,19].…”

Section: Introductionmentioning

confidence: 99%

Bio Technological Intervention with Platelet Rich Plasma for Assisted Regeneration of Sole

Shrivastava¹,

Naik²,

Patil³

et al. 2017

J Tissue Sci Eng

View full text Add to dashboard Cite

With the advent of Regenerative medicine products in medicine, newer solutions are getting evolved for complex conditions. The Cellular therapies offer a new ray of hope by inducing regeneration of tissue at the site of damage. The cellular therapy led by platelet rich plasma (PRP) is one such key regenerative product. But there is a huge variability in its usage, particularly for wounds. The standardisation for clinical usage is not yet evolved, hence limiting the clinical application of the same.The authors have developed a standard protocol "STARS" therapy, which utilises PRP as biotechnological tool, re-engineering the damaged tissue and gradually assisting the regeneration.In this study we report 8 cases of wounds/ulcers over the sole being treated by it. The results are excellent and offer a milestone solution to non-healing wounds/ulcers over soles. These wounds are otherwise, very difficult to treat particularly as they are associated with high risks factors such as infection, Diabetes and old age. They are under constant pressure due to weight bearing and give way easily and do not heal.The bioenginreeing of the sole tissues through PRP led STARS intervention is safe, effective and easily reproducible.

show abstract

The use of autologous PRP gel as an aid in the management of acute trauma wounds

Cited by 132 publications

References 24 publications

Platelet-Rich Plasma Application for Acute Tympanic Membrane Perforations

Platelet-Rich Plasma Application for Acute Tympanic Membrane Perforations

Heparan Sulfate Proteoglycan Mimetics Promote Tissue Regeneration: An Overview

Bio Technological Intervention with Platelet Rich Plasma for Assisted Regeneration of Sole

Contact Info

Product

Resources

About