The use of autologous platelet-rich plasma in the treatment of intractable skin ulcer: A case series

Kakudo, Natsuko; Kushida, Satoshi; Ogura, Tokuhiro; Hara, Tomoya; Suzuki, Kenji; Kusumoto, Kenji

doi:10.4236/ojrm.2012.13005

Cited by 19 publications

(18 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kakudo et al [15] treated five cases of intractable skin ulcer with autologous PRP, among which three ulcers healed completely within 4 weeks and epithelization of wound occurred within 6.6 weeks on average.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of autologous platelet-rich plasma in the treatment of chronic nonhealing leg ulcers

Suryanarayan¹,

Budamakuntla²,

Khadri³

et al. 2014

Plast Aesthet Res

View full text Add to dashboard Cite

considerable costs. [1] The prevalence of leg ulcers is well documented to be vary between 0.18% and 1%. [2] The three major causes of lower extremity ulcers are venous, arterial, and neuropathic. Chronic nonhealing ulcers lack the necessary growth factors (GFs) and hence do not heal well. Conventional recombinant GF products, including becaplermin (recombinant platelet-derived GF) have been approved by the Food and Drug Administration for the treatment of chronic wounds. However, the medication is in a liquid form, and, therefore, easily dissipates following wound application. In addition, it is expensive and is unaffordable in developing countries such as India. [3] Platelet-rich plasma (PRP) enhances wound healing through promotion of the healing process by the presence

show abstract

Section: Discussionmentioning

confidence: 99%

Efficacy of autologous platelet-rich plasma in the treatment of chronic nonhealing leg ulcers

Suryanarayan¹,

Budamakuntla²,

Khadri³

et al. 2014

Plast Aesthet Res

View full text Add to dashboard Cite

show abstract

“…Platelets release numerous growth factors from their α-granules [25] that can modulate cell proliferation and differentiation and accelerate soft tissue repair in vivo [26] . The α-granules contain platelet-derived growth factor, vascular endothelial growth factor, transforming growth factor-β, insulin-like growth factor, and fibroblast growth factor to name a few that stimulate proliferative and differentiation activities and improve wound healing via autocrine and paracrine mechanisms [27][28][29] . There exist little data in the literature about retinal wound healing and possible supportive effects of autologous platelets.…”

Section: Mh Closure Ratesmentioning

confidence: 99%

Persistent Full-Thickness Idiopathic Macular Hole: Anatomical and Functional Outcome of Revitrectomy with Autologous Platelet Concentrate or Autologous Whole Blood

Purtskhvanidze¹,

Frühsorger²,

Bartsch³

et al. 2017

Ophthalmologica

View full text Add to dashboard Cite

Purpose: To evaluate long-term outcome after revitrectomy with autologous platelet concentrate (APC) or whole blood (WB) in persistent idiopathic macular hole (MH) after vitrectomy with internal limiting membrane (ILM) peeling. Procedures: Retrospective study of 75 eyes with persistent MH after vitrectomy with ILM peeling and gas. All patients underwent revitrectomy with gas and APC (n = 61) or WB (n = 14). Main outcome measures were anatomical closure rate and postoperative best-corrected visual acuity (BCVA). Results: Closure rate after revitrectomy was 85.2% (52/61) in the APC group and 7.1% (1/14) in the WB group. Median follow-up was 58 (range 3-147) months. Median BCVA (logMAR) in patients with finally closed MHs was 0.4 ± 0.3. Patients with defects of the ellipsoid zone had significantly worse postoperative BCVA. Morphological MH configuration (atrophic or elevated edges) did not correlate with final closure rate. Conclusions: Revitrectomy with APC and gas is a very effective treatment in persistent MH after vitrectomy with ILM peeling and gas.

show abstract

“…20 Kakudo et al treated five cases of intractable skin ulcer with autologous PRP, among which three ulcers healed completely within 4 weeks and epithelization of wound occurred within 6.6 weeks on average. 21 Till now there is no standard method of preparation of PRP in literature. According to Marx, the device must use a double centrifugation technique.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of autologous platelet rich plasma versus regular dressing in chronic wounds

Asıf¹,

Chandramouli²

2019

Int Surg J

View full text Add to dashboard Cite

Background: Chronic wounds are a frequent problem and pose a heavy burden to the service provider. Platelet extract containing several growth factors used on chronic wounds has shown impressive results in both healing percentage and time for epithelisation. Platelet extract from the patient's own blood has been used in trials as a cheap and equally effective alternative to commercial platelet gels. The aim of the study was to demonstrate the therapeutic role of autologous platelet rich plasma (APRP) in epithelialisation and reduction in size of chronic wounds of lower limb. Methods: It is a case control study, conducted at Sri this study consisted of 30 patients with chronic ulcers between the age group of 18-80 years, with duration of ulcer ranging from 12 to 26 weeks. After obtaining consent they were randomly allotted into control and test groups with 15 patients each. Control group patients were treated with conventional dressing and in test group APRP dressing was done. Later percentage decrease in wound size was assessed. Results: Ulcer size decreased significantly (p<0.0001) in test group compared to control group. No unwanted effects or complications noted. Conclusions: APRP is a safe and effective treatment modality for chronic non-healing ulcers. It enhances healing and also decreases the associated cost and morbidity. Further research and randomized controlled clinical trials on larger patient population are necessary to validate the results.

show abstract

The use of autologous platelet-rich plasma in the treatment of intractable skin ulcer: A case series

Cited by 19 publications

References 8 publications

Efficacy of autologous platelet-rich plasma in the treatment of chronic nonhealing leg ulcers

Efficacy of autologous platelet-rich plasma in the treatment of chronic nonhealing leg ulcers

Persistent Full-Thickness Idiopathic Macular Hole: Anatomical and Functional Outcome of Revitrectomy with Autologous Platelet Concentrate or Autologous Whole Blood

Efficacy of autologous platelet rich plasma versus regular dressing in chronic wounds

Contact Info

Product

Resources

About