The Use of Autologous Fat Grafting for Treatment of Scar Tissue and Scar-Related Conditions

Negenborn, Vera L.; Groen, Jan-Willem; Smit, Jan Maerten; Niessen, Frank B.; Mullender, Margriet G.

doi:10.1097/prs.0000000000001850

Cited by 84 publications

(43 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…no improvement in discoloration). Thus, the overall trend is that lipofilling improves scar appearance in several different outcome measures, which is confirmed by two systematic reviews (Conde‐Green et al , ; Negenborn et al , ). However, due to lack of uniformity in intervention and follow‐up, no definitive conclusions can be drawn.…”

Section: Lipofilling As a Methods To Treat Scarsmentioning

confidence: 66%

The power of fat and its adipose-derived stromal cells: emerging concepts for fibrotic scar treatment

Spiekman

Dongen

Willemsen

et al. 2017

J Tissue Eng Regen Med

View full text Add to dashboard Cite

Lipofilling or lipografting is a novel and promising treatment method for reduction or prevention of dermal scars after injury. Ample anecdotal evidence from case reports supports the scar‐reducing properties of adipose tissue grafts. However, only a few properly controlled and designed clinical trials have been conducted thus far on this topic. Also, the underlying mechanism by which lipofilling improves scar aspect and reduces neuropathic scar pain remains largely undiscovered. Adipose‐derived stromal or stem cells (ADSC) are often described to be responsible for this therapeutic effect of lipofilling. We review the recent literature and discuss anticipated mechanisms that govern anti‐scarring capacity of adipose tissue and its ADSC. Both clinical and animal studies clearly demonstrated that lipofilling and ADSC influence processes associated with wound healing, including extracellular matrix remodelling, angiogenesis and modulation of inflammation in dermal scars. However, randomized clinical trials, providing sufficient level of evidence for lipofilling and/or ADSC as an anti‐scarring treatment, are lacking yet warranted in the near future. © 2017 The Authors Journal of Tissue Engineering and Regenerative Medicine Published by John Wiley & Sons Ltd

show abstract

Section: Lipofilling As a Methods To Treat Scarsmentioning

confidence: 66%

The power of fat and its adipose-derived stromal cells: emerging concepts for fibrotic scar treatment

Spiekman

Dongen

Willemsen

et al. 2017

J Tissue Eng Regen Med

View full text Add to dashboard Cite

show abstract

“…Autologous fat grafting has been widely investigated and used for softtissue defects and regenerative purposes such as the treatment of open wounds as well as antiscarring treatments (Han, Kim, & Kim, 2010;Jaspers et al, 2017;Negenborn, Groen, Smit, Niessen, & Mullender, 2016;Stasch et al, 2015). Diabetes is associated with dysfunctional wound healing and occurrence of nonhealing ulcers.…”

Section: Introductionmentioning

confidence: 99%

Adipose tissue‐derived extracellular matrix hydrogels as a release platform for secreted paracrine factors

Dongen

Getova

Brouwer

et al. 2019

J Tissue Eng Regen Med

View full text Add to dashboard Cite

Fat grafting is an established clinical intervention to promote tissue repair. The role of the fat's extracellular matrix (ECM) in regeneration is largely neglected. We investigated in vitro the use of human adipose tissue‐derived ECM hydrogels as release platform for factors secreted by adipose‐derived stromal cells (ASCs). Lipoaspirates from nondiabetic and diabetic donors were decellularized. Finely powdered acellular ECM was evaluated for cell remainders and DNA content. Acellular ECM was digested, and hydrogels were formed at 37°C and their viscoelastic relaxation properties investigated. Release of ASC‐released factors from hydrogels was immune assessed, and bio‐activity was determined by fibroblast proliferation and migration and endothelial angiogenesis. Acellular ECM contained no detectable cell remainders and negligible DNA contents. Viscoelastic relaxation measurements yielded no data for diabetic‐derived hydrogels due to gel instability. Hydrogels released several ASC‐released factors concurrently in a sustained fashion. Functionally, released factors stimulated fibroblast proliferation and migration as well as angiogenesis. No difference between nondiabetic and diabetic hydrogels in release of factors was measured. Adipose ECM hydrogels incubated with released factors by ASC are a promising new therapeutic modality to promote several important wound healing‐related processes by releasing factors in a controlled way.

show abstract

“…Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial [144] 2019 derer der Wundheilung [5,74,[130][131][132], zur Behandlung von Verbrennungen [131,133], zur Verhinderung von unschöner Narbenbildung [134,135] und zur Förderung der Nervenregeneration [136][137][138]…”

Section: Klinische Studie Jahr Zell-ursprungunclassified

Stammzellen in der Regenerativen Medizin – Translationale Hürden und Möglichkeiten zur Überwindung

Klietz

Kückelhaus

Kaiser³

et al. 2020

Handchir Mikrochir Plast Chir

View full text Add to dashboard Cite

ZusammenfassungDer Einsatz von mesenchymalen Stammzellen in der regenerativen Medizin wird immer populärer. Nichtsdestotrotz ist ihre Anwendung im klinischen Alltag noch immer limitiert. Zahlreiche ethische, rechtliche und translationale Probleme sowie Ungewissheit bzgl. der Sicherheit hemmen noch immer die Entstehung von entsprechenden Therapien aus vielversprechenden wissenschaftlichen Ansätzen.Diese Arbeit soll die Hauptprobleme bei der Translation von stammzellbasierten Therapien aus der Grundlagenforschung und Präklinik in den klinischen Alltag darstellen, sowie Ansätze aufzeigen, diese zu überwinden.

show abstract

The Use of Autologous Fat Grafting for Treatment of Scar Tissue and Scar-Related Conditions

Cited by 84 publications

References 60 publications

The power of fat and its adipose-derived stromal cells: emerging concepts for fibrotic scar treatment

The power of fat and its adipose-derived stromal cells: emerging concepts for fibrotic scar treatment

Adipose tissue‐derived extracellular matrix hydrogels as a release platform for secreted paracrine factors

Stammzellen in der Regenerativen Medizin – Translationale Hürden und Möglichkeiten zur Überwindung

Contact Info

Product

Resources

About