The Use of Artificial Dermis in the Reconstruction of Oncologic Surgical Defects

Abstract

Artificial bilaminate acellular dermis is an excellent option for reconstructing defects created by tumor resection and can be used in a wide variety of locations. It is especially useful in large defects that usually require flaps for coverage. Patients experience minimal donor-site morbidity and have outstanding cosmetic and functional results.

Conservative Surgery for Subungual Melanoma <i>In Situ</i> Using Matriderm<sup>&reg</sup>

“…Most of the experience with artificial dermis was obtained in the management of acute burns. In the oncologic population, advantages include fewer problems with hypertrophic scarring and less need for multiple operations and scar contractures [9].…”

“…Nevertheless, after this kind of procedure (total-thickness skin graft) or second intention healing, patients often complain about cutaneous sensitivity and scar pain. Although skin grafts and either local or distant flaps offer adequate coverage, they often fail to provide good aesthetic results and may require additional revisions to correct abnormalities [9]. Use of a biosynthetic dermal substitute may decrease donor-site morbidity and help improve limb function and scar quality.…”

Bioresorbable Polymers for Tissue Engineering

“…After the completion of regeneration, the neodermis is histologically and functionally similar to normal dermis [98,99]. This dermal substitute is considered to be an effective treatment for burns and tissue reconstruction in patients with cancer [100,101]. Since these first results, various research groups have worked to improve the device in an attempt to optimize outcomes and to reduce production costs.…”

The usefulness of the collagen and elastin sponge derived from salmon as an artificial dermis and scaffold for tissue engineerin

“…It has been used as a biomaterial which covers fullthickness skin defects for the treatments of diseases and conditions such as burn (13,30,42), trauma (16), chronic skin ulcer (2, 10), excised skin tumor (23,33,38) and others that cause full-thickness skin defects. The main ability of collagen sponge is to accelerate tissue granulation (7), as forming good granulation from a relatively early stage-even on a tendon (18, 37) and bone (16,23,38,42), which generally takes a long time to form. And this ability is able to make a wound heal fast by using secondary skin grafting.…”

“…And this ability is able to make a wound heal fast by using secondary skin grafting. The combined treatment with collagen sponge and skin grafting is less invasive for patients than other operative methods covering skin defects, such as local skin flaps, pedicled flaps, and free flaps because it is technically easy and takes a short time to perform the combination treatment (23,38). Collagen sponge is a very important treatment tool in dermatology and plastic reconstructive surgery.…”