The Use of Antioxidants in the Prevention and Treatment of Noise-Induced Hearing Loss

Hullfish, Haley; Roldan, Luis P.; Hoffer, Michael E.

doi:10.1016/j.otc.2022.06.006

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…This number roughly equates to 40 million persons between the ages of 20 and 69. 3 In 2017 the prevalence of sensorineural deafness in the United States reached 48 million people or around 20% of the population of the United States in various degrees of severity. Sensorineural deafness is not only suffered by individuals of advanced age but also those of productive age.…”

Section: Introductionmentioning

confidence: 99%

“…Among the most extensively studied are N-acetyl-cysteine (NAC), methionine, acetyl-L-carnitine (ALCAR), and resveratrol. 3 N-Acetylcysteine (NAC) is a drug approved by the Food and Drug Administration (FDA) and recognized by the World Health Organization (WHO) as an essential drug. 7 N-acetylcysteine (NAC) is a chemical that contains sulfhydryl and has mucolytic characteristics.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of N-Acetylcysteine on Noise Induced Hearing Loss :A Systematic Review

Omasih Kiantimi,

Yoga,

Pringga Dewi Astuti

2024

JARMHS

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Background: A preventable cause of sensorineural hearing loss (SNHL) is noise-induced hearing loss (NIHL). An essential factor in the pathophysiology of NIHL is oxidative stress. NAC is associated with its antioxidant and anti-inflammatory activity, which favors the maintenance of a cellular redox imbalance. As such, its potential for treatment relates to several diseases whose origins and progression are linked to oxidative stress. The aim: This study aims to show the effect of N-Acetyl-Cysteine on sensorineural hearing loss. Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2008 and 2023 were taken into account. Several different online reference sources, like Pubmed and ScienceDirect, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done. Results: In the PubMed database, the results of our search brought up 37 articles, whereas the results of our search on ScienceDirect brought up 38 articles. The results of the search conducted by screening yielded a total 6 articles for PubMed and 1 article for ScienceDirect. We excluded 1 article having ineligible intervention, and 1 article having ineligible outcomes data. In the end, we included five research that met the criteria. Conclusion: We found positive results in most of the studies, N-acetylcysteine showed better effect on reducing hearing loss and increasing hearing recovery in NIHL and the most common adverse events symptoms reported were gastrointestinal.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effects of N-Acetylcysteine on Noise Induced Hearing Loss :A Systematic Review

Omasih Kiantimi,

Yoga,

Pringga Dewi Astuti

2024

JARMHS

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“…Radical scavenging agents, or antioxidants, can alleviate oxidative stress by donating extra electrons to quench the reaction and prevent the aforementioned detrimental effects. The development of effective and biocompatible antioxidants is, therefore, vital to addressing a variety of complex health conditions [ 1 , 5 , 6 , 7 , 8 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. Currently, vitamin C [ 26 , 39 ], vitamin E [ 26 , 35 , 40 , 41 , 42 , 43 , 44 ], and beta carotene [ 45 , 46 ] are clinically proven antioxidant supplements capable of bolstering the body’s defense against ROS, thereby alleviating oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Doped Graphene Quantum Dots as Biocompatible Radical Scavenging Agents

Bhaloo,

Nguyen,

Lee

et al. 2023

Antioxidants

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Oxidative stress is proven to be a leading factor in a multitude of adverse conditions, from Alzheimer’s disease to cancer. Thus, developing effective radical scavenging agents to eliminate reactive oxygen species (ROS) driving many oxidative processes has become critical. In addition to conventional antioxidants, nanoscale structures and metal–organic complexes have recently shown promising potential for radical scavenging. To design an optimal nanoscale ROS scavenging agent, we have synthesized ten types of biocompatible graphene quantum dots (GQDs) augmented with various metal dopants. The radical scavenging abilities of these novel metal-doped GQD structures were, for the first time, assessed via the DPPH, KMnO4, and RHB (Rhodamine B protectant) assays. While all metal-doped GQDs consistently demonstrate antioxidant properties higher than the undoped cores, aluminum-doped GQDs exhibit 60–95% radical scavenging ability of ascorbic acid positive control. Tm-doped GQDs match the radical scavenging properties of ascorbic acid in the KMnO4 assay. All doped GQD structures possess fluorescence imaging capabilities that enable their tracking in vitro, ensuring their successful cellular internalization. Given such multifunctionality, biocompatible doped GQD antioxidants can become prospective candidates for multimodal therapeutics, including the reduction of ROS with concomitant imaging and therapeutic delivery to cancer tumors.

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Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review

Santaolalla Sanchez,

Gutierrez Posso,

Santaolalla Montoya

et al. 2024

Antioxidants

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Noise-induced hearing loss (NIHL) is responsible for significant adverse effects on cognition, quality of life and work, social relationships, motor skills, and other psychological aspects. The severity of NIHL depends on individual patient characteristics, sound intensity, and mainly the duration of sound exposure. NIHL leads to the production of a reactive oxygen (ROS) inflammatory response and the activation of apoptotic pathways, DNA fragmentation, and cell death. In this situation, antioxidants can interact with free radicals as well as anti-apoptotics or anti-inflammatory substances and stop the reaction before vital molecules are damaged. Therefore, the aim of this study was to analyze the effects of different pharmacological treatments, focusing on exogenous antioxidants, anti-inflammatories, and anti-apoptotics to reduce the cellular damage caused by acoustic trauma in the inner ear. Experimental animal studies using these molecules have shown that they protect hair cells and reduce hearing loss due to acoustic trauma. However, there is a need for more conclusive evidence demonstrating the protective effects of antioxidant/anti-inflammatory or anti-apoptotic drugs’ administration, the timeline in which they exert their pharmacological action, and the dose in which they should be used in order to consider them as therapeutic drugs. Further studies are needed to fully understand the potential of these drugs as they may be a promising option to prevent and treat noise-induced hearing loss.

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The Use of Antioxidants in the Prevention and Treatment of Noise-Induced Hearing Loss

Cited by 4 publications

References 41 publications

The Effects of N-Acetylcysteine on Noise Induced Hearing Loss :A Systematic Review

The Effects of N-Acetylcysteine on Noise Induced Hearing Loss :A Systematic Review

Doped Graphene Quantum Dots as Biocompatible Radical Scavenging Agents

Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review

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