The use of antioxidant agents for chemotherapy‐induced peripheral neuropathy treatment in animal models

Abstract

SummaryAntineoplastic drugs such as cisplatin, oxaliplatin, paclitaxel and vincristin are widely used in the treatment of several solid and blood tumours. However, the severity of peripheral neuropathy caused by these agents can affect the patient's quality of life.The major symptoms of chemotherapy-induced peripheral neuropathy (CIPN) involve: sensory loss, paresthesia, dysesthaesia, numbness, tingling, temperature sensitivity, allodynia and hyperalgesia, in a "stocking and glove" distribution. Why many different chemotherapeutic agents result in similar neuropathy profiles is unclear. Many drug classes such as antidepressants, anticonvulsants, antispastic agents and others have been used in clinical practice, but there is no scientific evidence to prove their effectiveness. But drugs as the antioxidant have shown a protective effect against free radical damage. In order to find out a successful treatment for CIPN, animal studies (ie pharmacological and mechanical tests and histopathological immunohistochemical analyses) have been developed to try to determinate the action of the antioxidant agents. This review provides an overview of the major antioxidant agents recently investigated to treat CIPN and the animal models used for this purpose. K E Y W O R D Santineoplastic drugs, antioxidants, peripheral neuropathy

<p>Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain</p>

“…[6][7][8] Specifically, ROS scavengers such as N-tert-butyl-α-phenylnitrone, 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl and vitamin E were shown to reverse mechanical allodynia. [9][10][11] Though ROS is known to play a major role in establishing and maintaining NP, there is a shortage of effective clinical treatments that primarily target ROS system. Collectively, these studies suggest that ROS play an important role in central sensitization mechanism for mechanical allodynia and it is worth studying the effect of ROS scavengers in neuropathic pain treatment.…”

Neurotoxicity as a side effect of taxanes in cancer patients

“…Поскольку описанный механизм является ключевым в физиопатологии химиоиндуцированной периферической нейропатии, считается, что антиоксидантная терапия является эффективной альтернативой для предотвращения развития ХИПН [42]. Рецепторы, активируемые пролифераторами пероксисом (РАПП), являются важными членами семейства ядерных рецепторов, которые вызывают активацию нескольких генов, действуя в качестве лиганд-активированного фактора транскрипции [43].…”

Advances in cellular evaluation and standard of antioxidant activity

“…As evidenced by many oxidative stress models, tea and polyphenols can prevent or attenuate the decrease of antioxidant enzyme activity. Supplementation of green tea polyphenols to drinking water can significantly inhibit the decrease of catalase and glutathione reductase activity in epidermis of hairless mice induced by UVB [9]. In addition, oral test in mice infected with Mycobacterium tuberculosis showed that green tea extract could also prevent the decrease of superoxide dismutase activity [10].…”

“…However and importantly, antioxidant agents have protective effects on free radical damage. The therapeutic effect of antioxidants on peripheral neuropathy has been detected by many studies with established animal models [9]. Additionally, research team led by Gong [12] and Vashistha [13] studied the effect of matrine and ferulic acid on vincristine-induced neuropathic pain in animal models, respectively.…”