The use of antimicrobial biomaterials as a savior from post-operative vascular graft-related infections: A review

Murugan, Dhanashree; Rangasamy, Loganathan

doi:10.1016/j.rineng.2022.100662

Cited by 5 publications

(3 citation statements)

References 60 publications

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“…Kabirian et al [123] and Murungan and Rangasamy [124] highlighted that antimicrobial agents can also be incorporated with biomaterials to increase the antimicrobial activity of vascular grafts. However, it has been observed that these grafts also provide bactericidal activity against Staphylococcus aureus and Escherichia coli.…”

Section: Alternative Medical Solutionsmentioning

confidence: 99%

Innovative Biomedical and Technological Strategies for the Control of Bacterial Growth and Infections

Matias,

Damasceno,

Pereira

et al. 2024

Biomedicines

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Antibiotics comprise one of the most successful groups of pharmaceutical products. Still, they have been associated with developing bacterial resistance, which has become one of the most severe problems threatening human health today. This context has prompted the development of new antibiotics or co-treatments using innovative tools to reverse the resistance context, combat infections, and offer promising antibacterial therapy. For the development of new alternatives, strategies, and/or antibiotics for controlling bacterial growth, it is necessary to know the target bacteria, their classification, morphological characteristics, the antibiotics currently used for therapies, and their respective mechanisms of action. In this regard, genomics, through the sequencing of bacterial genomes, has generated information on diverse genetic resources, aiding in the discovery of new molecules or antibiotic compounds. Nanotechnology has been applied to propose new antimicrobials, revitalize existing drug options, and use strategic encapsulating agents with their biochemical characteristics, making them more effective against various bacteria. Advanced knowledge in bacterial sequencing contributes to the construction of databases, resulting in advances in bioinformatics and the development of new antimicrobials. Moreover, it enables in silico antimicrobial susceptibility testing without the need to cultivate the pathogen, reducing costs and time. This review presents new antibiotics and biomedical and technological innovations studied in recent years to develop or improve natural or synthetic antimicrobial agents to reduce bacterial growth, promote well-being, and benefit users.

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Section: Alternative Medical Solutionsmentioning

confidence: 99%

Innovative Biomedical and Technological Strategies for the Control of Bacterial Growth and Infections

Matias,

Damasceno,

Pereira

et al. 2024

Biomedicines

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show abstract

“…In this context, 3D bioprinting, and even 4D bioprinting, may be an effective technology with the potential to produce patient-tailored grafts with major resistance to several biological assaults, thus, overcoming a series of complications [149][150][151][152][153][154]. Thus, the ideal engineered graft should have the biomechanical, morphologic, and cellular characteristics of a human vessel [155].…”

Section: Future Perspectivesmentioning

confidence: 99%

Infection of Vascular Prostheses: A Comprehensive Review

et al. 2023

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Vascular graft or endograft infection (VGEI) is a complex disease that complicates vascular-surgery and endovascular-surgery procedures and determines high morbidity and mortality. This review article provides the most updated general evidence on the pathogenesis, prevention, diagnosis, and treatment of VGEI. Several microorganisms are involved in VGEI development, but the most frequent one, responsible for over 75% of infections, is Staphylococcus aureus. Specific clinical, surgical, radiologic, and laboratory criteria are pivotal for the diagnosis of VGEI. Surgery and antimicrobial therapy are cornerstones in treatment for most patients with VGEI. For patients unfit for surgery, alternative treatment is available to improve the clinical course of VGEI.

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“…Antibiotics and their related drug resistance have caused multiple adverse effects that included and not limited to drug toxicity. Therefore, the search for a new therapeutic route with lower challenges and better outcomes is targeted by multiple scientific researches (Murugan and Rangasamy 2022 ). Recently, nanoparticle-based targeted delivery strategies was represented as a new pathway in treatment of MDR infections, by using less therapeutic dosages of antibiotics leading to lower side effects or combining nanoparticles with various antibiotics, and observing their effect on MDR bacteria (Abdelkader et al 2017 ; Lahiri et al 2022 ; Qing et al 2019 ; Rajivgandhi et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

The impact and safety of encapsulated nanomaterials as a new alternative against carbapenem resistant bacteria. a systematic review

Abdallah,

Shebl,

Abdelsalam

et al. 2024

World J Microbiol Biotechnol

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The emergence of multi drug resistant bacterial infections has caused a critical problem with implication on hospitalization and mortality rates. This systematic review aims to review the combined antimicrobial effect of nanoparticles attached to the traditionally used antibiotics, to overcome the antibiotic resistance crisis. In this systematic search we focused on preclinical studies that have used animal models, to test and evaluate the effect of nanomaterials added to antibiotics against gram negative bacteria with carbapenem resistance. Where, this newly formed structure has led to significant decrease in bacterial load in animal model serum. Furthermore, by evaluating nanomaterial cytotoxicity and inflammatory markers, promising results were established, where low toxicity indices were presented, supporting the ability of this new pathway to be used as an alternative to abused antibiotics. Our research collected the various data and showed encouraging preclinical one for using nanomaterials with antibiotics. This undeniable route should be considered, due to its ability to contribute to the treatment of multi drug resistant bacterial infections. These findings provide base for future studies and reinforce the need for more evaluation and testing on the safety of nanomaterials against bacterial infections.

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The use of antimicrobial biomaterials as a savior from post-operative vascular graft-related infections: A review

Cited by 5 publications

References 60 publications

Innovative Biomedical and Technological Strategies for the Control of Bacterial Growth and Infections

Innovative Biomedical and Technological Strategies for the Control of Bacterial Growth and Infections

Infection of Vascular Prostheses: A Comprehensive Review

The impact and safety of encapsulated nanomaterials as a new alternative against carbapenem resistant bacteria. a systematic review

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