The use of antihistamines in patients with asthma

Sly, R. Michael; Kemp, James P.; Anderson, John A.; Bierman, C. Warren; Brandon, Milan L.; Bronstein, Herbert A.; Brown, Edwin G.; Chervinsky, Paul; Cogen, Frederick C.; Dockhorn, Robert J.; Easton, James G.; Falliers, Constantine J.; Finegold, Ira; Friedlaender, Sidney; Furukawa, Clifton T.; Gillman, Sherwin A.; Girsh, Leonard S.; Glazer, I; Handelman, Nathan I.; Hannaway, Paul J.; Hendeles, Leslie; Hermance, William E.; Kadlec, G J; Katz, Roger M.; Kaufman, Herbert S.; Knight, Allan; Kordansky, Daniel W.; Krumholz, Richard A.; Labraico, James; Lanoff, G; Land, Robert N.; London, Richard L.; Mayer, Lloyd D.; McKee, W. D.; Meltzer, Eli O.; Miller, Jerome; Murphy, Shirley A.; Nicklas, Richard A.; Rappaport, I; Rowe, Michael; Schuller, Diane E.; Segal, Allen T.; Shapiro, Gail G.; Siegel, Sheldon C.; Siegler, Peter; Simons, F. Estelle R.; Sutton, Paul; Szefler, Stanley J.; Szentivanyi, Andor; Tennenbaum, James I.; Thruston, Donald L.; Tobey, Raymond E.; Weinberger, Miles; Welch, Michael J.; Woehler, Thomas; Yamate, Minoru; Zweiman, Burton

doi:10.1016/0091-6749(88)90022-x

Cited by 20 publications

(2 citation statements)

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“…H 1 ‐antihistamines are considered adjunctive drugs for anaphylaxis ( 15). Although once considered by many clinicians and regulatory authorities to be contraindicated in asthma ( 16), it is now clear that the second‐generation antihistamines are safe in asthma ( 17). Furthermore, cetirizine was shown to reduce the cardinal symptoms of asthma ( 18, 19).…”

mentioning

confidence: 99%

A double‐blind, single‐dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine‐induced wheal and flare response for 24 h in healthy male subjects

Danielson

et al. 1999

Allergy

102

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mentioning

confidence: 99%

A double‐blind, single‐dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine‐induced wheal and flare response for 24 h in healthy male subjects

Danielson

et al. 1999

Allergy

102

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“…their capacity to produce and release secondary mediators [12]. Accordingly, there is now an accumulation of pharmacological and pathophysiologicai data which appear to justify reopening the file and reviewing the old statements about the contra-indication of antihistamines in asthma [13]. Indeed, their use may certainly be recommended in the treatment of at least some forms of asthma, such as associated seasonal rhinoconjunctivitis and asthma [7].…”

Section: Clinical Relevance Of the Pathophysiological Properties Of Tmentioning

confidence: 99%

Does the clinical experience with non‐sedating H₁‐antagonists justify a reassessment of antihistamines in allergy treatment?

Weck

1990

Clin Experimental Allergy

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Although antihistamines were usually considered as ineffective in asthma, the appearance of new more potent anti-'1-antagonists with no or less side-effects leads to a reassessment of their use. Although mediators and mechanisms other than histamine are involved in natural or provoked reactions to allergens in the skin, the nose or the lungs, the new anti-H1-antagonists have been shown to be effective. For some of these drugs, the effect may go beyond a mere H1-receptor blockade and involve impairment of mediator release from mast cells and/or an inhibiting effect on other cell types (e.g. eosinophils) implicated in the late-phase reactions. Quantitative kinetics evaluation of late-phase reactions in the skin and of their inhibition by anti-allergic drugs will be helped considerably by the development of telethermography, a new skin evaluation technique.

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Antihistamines in the Treatment of Bronchial Asthma. Present Knowledge and Future Perspectives

Mincarini

Pasquali

Cosentino

et al. 2001

Pulmonary Pharmacology & Therapeutics

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The use of antihistamines in patients with asthma

Cited by 20 publications

References 20 publications

A double‐blind, single‐dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine‐induced wheal and flare response for 24 h in healthy male subjects

A double‐blind, single‐dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine‐induced wheal and flare response for 24 h in healthy male subjects

Does the clinical experience with non‐sedating H₁‐antagonists justify a reassessment of antihistamines in allergy treatment?

Antihistamines in the Treatment of Bronchial Asthma. Present Knowledge and Future Perspectives

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The use of antihistamines in patients with asthma

Cited by 20 publications

References 20 publications

A double‐blind, single‐dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine‐induced wheal and flare response for 24 h in healthy male subjects

A double‐blind, single‐dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine‐induced wheal and flare response for 24 h in healthy male subjects

Does the clinical experience with non‐sedating H1‐antagonists justify a reassessment of antihistamines in allergy treatment?

Antihistamines in the Treatment of Bronchial Asthma. Present Knowledge and Future Perspectives

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Product

Resources

About

Does the clinical experience with non‐sedating H₁‐antagonists justify a reassessment of antihistamines in allergy treatment?