The Use of Antidepressants With Methadone in Depressed Maintenance Patients *

Superior methadone treatment outcome in Hmong compared with non-Hmong patients

“…Identification of factors associated with clinical retention may help in tailoring treatment approaches to reduce the risk of leaving treatment. For example, psychiatric comorbidity has predicted poor outcome in some studies and the provision of on-site psychotherapy or treatment for depression has improved treatment outcome (Woody et al, 1982; Woody et al, 1983; Nunes et al, 1991). Using evidence-based dosing regimens rather than set ceiling doses has also resulted in improved retention (Ball & Ross, 1991; Caplehorn & Bell, 1991).…”

Imipramine Treatment of Opiate-Dependent Patients With Depressive Disorders

“…None showed a clear effect on drug abuse. Methodological limitations 34 include small sample sizes, short trial lengths, low doses, and high placebo response rates, 29,30,32 perhaps because depressed subjects were selected with crosssectional symptom scales rather than clinical history and syndromal diagnosis. Depressive symptoms in substance abusers are often transient, [35][36][37] attributable to ORIGINAL ARTICLE a drug's toxic effects, drug withdrawal, or short-term life crises.…”

Anxiety and Substance Use Disorders

“…Abrupt cessation can also cause a discontinuation syndrome. These data further show that TCAs, especially doxepin, also decreased symptoms of anxiety in this group (Kleber et al, 1983;Titievsky, Seco, Barranco, & Kyle, 1982;Woody, O'Brien, & Rickels, 1975;Woody, O'Brien, McLellan, Marcovici, & Evans, 1982). TCAs should be avoided in patients at risk of suicide (Nutt, 2005b).…”