The use of anticoagulants in bacterial endocarditis

Kanis, John А.

doi:10.1136/pgmj.50.583.312

Cited by 25 publications

(3 citation statements)

References 12 publications

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“…Other groups have reported an alarming incidence of cerebral hemorrhage. [79][80][81][82][83] A trial of 115 patients with IE who were randomized to aspirin treatment reported the effect of aspirin therapy on the risk of embolic events in IE (n 5 60, 325 mg/d) or placebo (n 5 55) for 4 weeks ( Table 3 , Table S2). 84 The addition of aspirin did not reduce the risk of embolic events, with 17 (28.3%) such events in the aspirin group vs 11 (20.0%) in the placebo group (OR, 1.62; 95% CI, provides a strong indication for anticoagulation, and when technically feasible, closure of the PFO.…”

Section: Patent Foramen Ovale and Atrial Septal Aneurysmmentioning

confidence: 99%

Antithrombotic and Thrombolytic Therapy for Valvular Disease

Whitlock

Sun

Fremes

et al. 2012

Chest

545

136

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Section: Patent Foramen Ovale and Atrial Septal Aneurysmmentioning

confidence: 99%

Antithrombotic and Thrombolytic Therapy for Valvular Disease

Whitlock

Sun

Fremes

et al. 2012

Chest

545

136

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“…The operative mortality was 37%. Anticoagulants were given to three patients while atrial arrhythmias were being controlled; in two the outcome was favourable while the third died with massive intracranial haemorrhage; these cases and our own views on the use of anticoagulants in infective endocarditis have been reported by Kanis (1974). OUTCOME In all, 37 patients died, a mortality rate of 46%.…”

Section: Incidencementioning

confidence: 88%

Infective endocarditis: a survey of cases in the South-East region of Scotland, 1969-72.

Smith¹,

Radford²,

Clark³

et al. 1976

Thorax

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. (1976). Thorax, 31,[373][374][375][376][377][378][379] Infective endocarditis: a survey of cases in the South-East of Scotland from 1969-72. The incidence and characteristics of infective endocarditis were studied in a defined community over a four-year period.Seventy-eight cases were found, giving an incidence of 16 cases per million per year. The commonest presenting features were those of infection; 53% had cardiac failure and 37% evidence of emboli when first seen. Twenty-three cases occurred on rheumatic heart valves, 13 on valvular prostheses, and 19 in previously normal hearts.Streptococcus viridans was the commonest organism, but there was a relatively high incidence of staphylococcal infection. Only four cases were preceded by dental manipulation, and no source for the infection was found in 46 patients.The mortality rate was 46%, cardiac failure and embolic phenomena accounting for 65% of deaths. It is unlikely that earlier diagnosis or cardiac surgery would have reduced the mortality appreciably.

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“…This view continued until challenged by Lerner and Weinstein 29 who believed it wise to use antibiotic and anticoagulant. In 1974, Kanis 30 reported a patient with bacterial endocarditis who died from embolic cerebral damage after treatment with heparin. It would appear that it continues to be unwise to use anticoagulant in this situation.…”

Section: Treatment Related To the Heartmentioning

confidence: 99%

Treatment of transient ischemic attacks.

Millikan¹,

McDowell²

1978

Stroke

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SUMMARY Transient ischemic attacks are the most important warning symptoms of impending stroke. They occur in up to one-half of all patients who develop stroke but, unfortunately, less than half of the patients who have them seek help from their physicians before stroke occurs. Physicians should regularly question patients about the possibility of such symptoms and patients with them should seek prompt help. When transient ischemic attack is diagnosed, patients should be evaluated for elevated blood pressure, hyperlipidemia, cardiac dysrhythmia, cardiac disease, anemia, polycythemia and thrombocytosis. When these conditions are found they should be treated. Patients with carotid system TIAs should be evaluated clinically and radiologically for evidence of vascular disease. The neck should be auscultated for bruit and absent pulses and the peripheral vessels palpated. Patients with carotid system TIAs should have angiography of all 4 cerebral vessels and the angiogram should be evaluated for the presence and number of arterial stenoses and the presence of ulcerated plaques. When patients with carotid system TIAs are found to have localized extracranial atherosclerotic obstruction or ulcerated plaques in a vessel appropriate to the side of their symptoms of cerebral ischemia, they should be considered for prompt surgical correction of the lesion. For patients with carotid system TIAs, who have multiple sites of extracranial vascular disease, medical treatment is advisable with either anticoagulants or platelet antiaggregating agents. In view of the recently reported favorable results using aspirin in the prevention of TIA and stroke, this agent may be preferable to anticoagulants in instances where hypertension, patient compliance and laboratory facilities are a problem.

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The use of anticoagulants in bacterial endocarditis

Cited by 25 publications

References 12 publications

Antithrombotic and Thrombolytic Therapy for Valvular Disease

Antithrombotic and Thrombolytic Therapy for Valvular Disease

Infective endocarditis: a survey of cases in the South-East region of Scotland, 1969-72.

Treatment of transient ischemic attacks.

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