The use of anticoagulants for thrombophlebitis during pregnancy

Neurological sequelae of intrauterine warfarin exposure

“…3 In their series of 33 patients treated with coumarin derivatives, one was born with optic atrophy and microcephaly. Prior to this report, coumarin derivatives had been associated with increased fetal loss and neonatal bleeding 4 but not with abnormal findings in live born infants.…”

Clinical Experience with Anticoagulant Therapy During Pregnancy

“…In this series Cases 3, 4, 7, 9, 11, 12, and 14 had severe or recurrent deep venous thrombosis, with or without pulmonary embolism; all were treated with heparin for at least two weeks and then with oral anticoagulants. This approach was taken because we thought that these patients were exposed to both local and general predisposing factors to thromboembolism for the duration of pregnancy (Quenneville et al, 1959;Johnson andGreenwalt, 1965: Gilliland, 1966).…”

“…Since it must be given parenterally, however, its long-term use is much less convenient than that of the oral anticoagulants. The latter drugs, on the other hand, have been shown to cross the placenta and to predispose to fetal haemorrhage, both experimentally (Quick, 1946;Kraus et al, 1949) and clinically (Quenneville et al, 1959;Finnerty and MacKay, 1962;Johnson and Greenwalt, 1965;Taylor, 1965;Villasanta, 1965aVillasanta, , 1965bGilliland, 1966). For this reason their use has generally been considered to be contraindicated dur-*Second Assistant.…”

Thromboembolische Komplikationen in der Schwangerschaft

“…card , in tra k a p s u lä re r T h y m u sb lu tu n g , M ed iastin alh äm ato m und L u n g e n b lu tu n g e n geboren w u rd e. Quenneville, Barton, M cD evill und W right [13] ü b erb lick en 33 S c h w a n g ersch aftsth ro m b o sen , die m it H e p a rin u n d C u m a rin d e riv a te n b e h a n d e lt w u rden. 3m al e n d ete die G ra v id itä t m it in tra u te rin e m F ru c h tto d .…”