The use of alternative lipid emulsions in paediatric and neonatal parenteral nutrition

BScDiet, Bd Saayman; Rd,

doi:10.1080/16070658.2011.11734378

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…Parents should be aware of possible estrogenic effects if they choose to feed their infants with soy-based formula 14 . Besides, it should be mentioned that soy-based oil emulsions were identified as one of the major causative factors of cholestasis related to the pediatric parenteral nutrition; further details and references are in 49 .…”

Section: Phytoestrogens and Soy Productsmentioning

confidence: 99%

Placebo in the guise of evidence-based medications

Jargin¹

2020

Arşiv Kaynak Tarama Dergisi

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Placebo therapy can be beneficial and ethically justifiable; but it is not a sufficient reason to publish biased information. Certain journals are selecting reliable reports but others are publishing biased materials and rejecting criticism. Publication series of questional reliability are sometimes continued without making references to published comments. Theories have been construed for promotion of some drugs and dietary supplements without proven effectiveness. This review is a collection of examples, when substances with unproven effects and unclear action mechanisms are directly or indirectly presented by professional publications as evidence-based medications. Some of the topics might be not completely clarified, so that arguments provided here can induce a constructive discussion.

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Section: Phytoestrogens and Soy Productsmentioning

confidence: 99%

Placebo in the guise of evidence-based medications

Jargin¹

2020

Arşiv Kaynak Tarama Dergisi

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“…Moreover, soy is known as allergenic food at least for some populations [ 2 ], [ 25 ]. Finally, it should be mentioned that soybean-based oil emulsions were identified as one of the major causes of cholestasis related to pediatric parenteral nutrition [ 26 ].…”

Section: Soy and Phytoestrogensmentioning

confidence: 99%

Soy and phytoestrogens: possible side effects

Jargin

2014

GMS German Medical Science; 12:Doc18; ISSN 1612-3174

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“…The use of phytoestrogens as an alternative for hormone replacement therapy is not advocated due to insufficient information on safety [22], and reports of adverse effects and interactions with drugs [23]. Moreover, soy is known as allergenic food [2,24], and soybeanbased oil emulsions have been identified as one of the major causes of cholestasis related to pediatric parenteral nutrition [25].…”

Section: Introductionmentioning

confidence: 99%

“…It should also be remarked that mixed preparations containing both phytoestrogens and estrogens, if phytoestrogens indeed bind selectively to the estrogen receptors [5], they might inhibit the action of the estrogens by competing with them for the binding sites, which would possibly increase the required dose. Phytoestrogens are used to compensate for hormone deficiency in the menopause, but their hormonal potential does not prevent the broad use of soy in infant food, other foodstuffs and pediatric parenteral nutrition [25]. Given the extensive use of soy for animal fodder, residual phytoestrogens and their active metabolites, in the first place equol, produced by intestinal bacteria in cattle and domestic fowl [27,28], can remain in meat and influence the hormonal balance of consumers.…”

mentioning

confidence: 99%

“…Phytoestrogens are used to compensate for hormone deficiency in the menopause, but their hormonal potential does not prevent the broad use of soy in infant food, other foodstuffs and pediatric parenteral nutrition [25]. Given the extensive use of soy for animal fodder, residual phytoestrogens and their active metabolites, in the first place equol, produced by intestinal bacteria in cattle and domestic fowl [27,28], can remain in meat and influence the hormonal balance of consumers.…”

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confidence: 99%

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Concerns about Soy Cultivation: What is Known and What is not Known

Sv¹

2014

Journal of Nutrition and Health Sciences

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There is abundant literature suggesting medical use for phytoestrogen-containing products. There is also published evidence suggesting potentially negative consequences of phytoestrogens use for humans. Substantiation of both concepts appears questionable. Meanwhile, soy products are used liberally in the food also for infants and children. The concept discussed here is that it is not consistent to support soy use for estrogenic effects without concern for its impact on routine use as a foodstuff and livestock fodder. It is important for thorough independent studies to be done to answer these questions. Phytoestrogens are substances of plant origin that are structurally and functionally similar to estrogens. Among them, isoflavones and coumestans are the most extensively studied groups. Isoflavones are present in different edible plants, but are most abundant in soy [1][2][3]. Consumption of soy products has been associated with favorable health effects, but potentially adverse effects are underacknowledged [4]. Phytoestrogens are advertised as a natural alternative to estrogens for hormone replacement therapy during menopause [1]. Preclinical trials have demonstrated both genomic and non-genomic action of phytoestrogens including selective but weak binding to the estrogen receptors [5]. Some epidemiological studies suggest that dietary intake of phytoestrogens may contribute to the decreased incidence of postmenopausal cardiovascular disease [6] and that phytoestrogens are significantly more effective than placebo in reducing the frequency of hot flashes [7]. Evidence in support of clinically relevant biological effects has been generally rated as insufficient or absent [5,[8][9][10][11][12][13][14]. A recent review concluded that in spite of increasing preclinical and clinical studies over the past decade, "appealing evidence is still lacking to support the overall positive risk-benefit profile of phytoestrogens" [15]. Then as now, the conventional menopausal hormone replacement therapy remains the only treatment that has consistently had a greater effect than placebo in controlled trials [16]. As evaluation of earlier works on enrichment the diet with soy products has failed to confirm favorable effects related to the cardiovascular system [17], doubts concerning phytoestrogens have recently increased. There is little evidence to support the hypothesis that phytoestrogens protect against menopausal osteoporosis, with published studies having no controls for confounding factors, the observations generally being of short duration [18,19]. In regard to osteoporosis, the latest review concluded that "evidence points to a lack of a protective role of soy isoflavones in the prevention of postmenopausal bone loss" [20], although in vitro and animal studies show some positive effect of isoflavones on bone which has not been clearly confirmed by long-term human trials [21]. There might be genetic differences in this regard, as equol producers seem to present a more positive response to isoflavone intervention ...

show abstract

The use of alternative lipid emulsions in paediatric and neonatal parenteral nutrition

Cited by 8 publications

References 10 publications

Placebo in the guise of evidence-based medications

Placebo in the guise of evidence-based medications

Soy and phytoestrogens: possible side effects

Concerns about Soy Cultivation: What is Known and What is not Known

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