The Use of ??-Agonists and the Risk of Death and Near Death from Asthma

Spitzer, Walter O.; Suissa, Samy; Ernst, Pierre; Horwitz, Ralph I.; Habbick, Brian F.; Cockcroft, Donald W.; Boivin, Jacky; McNutt, Mary; Buist, Sonia; Rěbuck, A. S.

doi:10.1097/00132586-199212000-00008

Cited by 100 publications

(128 citation statements)

References 0 publications

Supporting

Mentioning

117

Contrasting

Unclassified

Order By: Relevance

“…In adults, regular use of short-acting b 2 -agonists has been shown to be associated with deterioration of asthma control [11], and even with an increased risk of fatal and near-fatal asthma [12,13]. Fenoterol, in particular, has been observed to be a possible cause of an asthma mortality epidemic in New Zealand [14]; in the present study, the use of fenoterol was found only in a small number of cases.…”

Section: Discussioncontrasting

confidence: 40%

A nationwide survey in Germany on fatal asthma and near-fatal asthma in children: different entities?

Schmitz

Kries²,

Wjst³

et al. 2000

European Respiratory Journal

View full text Add to dashboard Cite

In adults fatal and near-fatal asthma have similar clinical characteristics. Therefore, near-fatal asthma in adults can be used as a model for fatal asthma. A nationwide study on fatal and near-fatal asthma in children <16 yrs was performed in order to assess whether, as in adults, near-fatal asthma can be used as a model for fatal asthma.From 1996 to 1998, all paediatric hospitals and paediatric pulmonologists in Germany were asked to report cases of fatal asthma and near-fatal asthma to a central survey unit (Erhebungseinheit fu È r seltene pa Èdiatrische Erkrankungen in Deutschland (ESPED)) on a monthly basis. All reports were followed by detailed questionnaires.Sixteen fatal and 45 near-fatal asthma cases were analysed. Fatal asthma patients were older than near-fatal asthma patients. Respiratory tract infections were frequently reported only in near-fatal asthma (47 versus 0%). The proportion of cases with rapid-type onset (duration of symptoms #1 h) was higher in fatal asthma (53 versus 14%). Long-term regular treatment with short acting b 2 -agonists was common in both groups, but the use of concomitant inhaled corticosteroids was significantly lower in fatal asthma cases. A high proportion of poor compliance was observed in both groups.As fatal and near-fatal asthma differ significantly in important clinical aspects, analysis of near-fatal asthma might be of limited value in elucidating the causes of fatal asthma in children. Eur Respir J 2000; 16: 845±849.

show abstract

Section: Discussioncontrasting

confidence: 40%

A nationwide survey in Germany on fatal asthma and near-fatal asthma in children: different entities?

Schmitz

Kries²,

Wjst³

et al. 2000

European Respiratory Journal

View full text Add to dashboard Cite

show abstract

“…In asthma, chronic ␤-agonist administration has been associated with tachyphylaxis in some 18,19 but clearly not all 20,21 studies. In addition, excessive ␤-agonist use has been associated with increased asthma mortality 22 and morbidity. 23 These associations with excess ␤-agonist use are not universally found, though, and it is not known whether tachyphylaxis per se is the basis of such observations.…”

Section: Pharmacogenetics Of ␤-Agonists In Asthmamentioning

confidence: 99%

The pharmacogenetics of asthma: a candidate gene approach

et al. 2001

View full text Add to dashboard Cite

“…18,19 The main causes for these possible effects have not been clarified yet and are still unknown, but have been related to inhaled drugs, especially via metered dose inhaler. 20 Worsening of asthma was not proved in recent studies.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of different doses of inhaled fenoterol on methacholine-induced bronchoconstriction in asthmatic children

et al. 1998

Sao Paulo Med. J.

View full text Add to dashboard Cite

Objective: To evaluate the protective effect of different doses of inhaled fenoterol (F) on bronchoconstriction induced by methacholine (M). Design: randomized double-blind study. Setting: Referrence center. Participants: 9 children (aged from 7 to 15 years old), with mild or moderate asthma and allergic to D. pteronyssinus. Intervention: On the first day, the M concentration necessary to induce a 20% fall in the forced expiratory volume in the first second (FEV 1 ; PC 20 FEV 1 ) was determined using closed circuit inhalation (De Vilbiss 646). On subsequent days, the children inhaled a dose of F (25 or 50 or 100 or 200 mg) through the same circuit and, after 15 minutes the FEV 1 was measured, becoming the basal value. Bronchoprovocation was then initiated using the concentration prior to the PC 20 FEV 1 of the first day and continuing until there was a 20% fall in the FEV 1 . This concentration was the "new" PC 20 FEV 1 . Results: F in a dose of 25 mg protected 2 of the 9 children, in a dose of 50 mg protected 4 of the 9 and in doses of 100 and 200 mg protected all children. We did not observe any relationship between the magnitude of the bronchodilation and bronchoprotection induced by the inhalation of F. Conclusions: Our results suggest that a dose of 100 mg of F is capable of inducing bronchoprotection in children with mild/moderate asthma. Uniterms: Asthma. Children. Bronchial hyperreactivity. Beta agonists. Fenoterol. Methacholine.

show abstract

The Use of ??-Agonists and the Risk of Death and Near Death from Asthma

Cited by 100 publications

References 0 publications

A nationwide survey in Germany on fatal asthma and near-fatal asthma in children: different entities?

A nationwide survey in Germany on fatal asthma and near-fatal asthma in children: different entities?

The pharmacogenetics of asthma: a candidate gene approach

Protective effects of different doses of inhaled fenoterol on methacholine-induced bronchoconstriction in asthmatic children

Contact Info

Product

Resources

About