The Use of a Surgical Grade Calcium Sulfate as a Bone Graft Substitute

Calcium Sulfate as Bone Graft Substitute in the Treatment of Osseous Bone Defects, A Prospective Study

“…Calcium sulphate, calcium phosphate, bioactive glass, biodegradable polymers and recombinant human BMPs are all offered as solutions to the problem of bone healing. Calcium sulphate was used alone without bone graft or other additives [10][11][12][13][14][15][16][17]. Currently calcium sulphate is available as medical grade calcium sulphate.…”

“…Although its external use of calcium sulfates as plaster of Paris dates back to the seventeenth century, there have been few studies using calcium sulfate as a bone graft substitute. Key features of this alloplast material include its biocompatibility, rapid resorption rate, and unique ability to stimulate osteogenesis [10][11][12][13][14][15][16]. An additional use for calcium sulfate is its reported use as a binding and stabilizing agent.…”

Function After Injection of Benign Bone Lesions with a Bioceramic

“…In a selective review, Rougraff documented the limited published data on the use of bone graft substitutes in orthopaedic oncology [24]. Most reported series using surgical-grade CaSO 4 [16,17,20,22] or CaPO 4 [21] graft materials to treat patients with benign bone tumors are relatively small with short followup. While various bone graft substitutes may be used to treat bone lesions, common complications still exist [16,17,20,21,24].…”

“…Most reported series using surgical-grade CaSO 4 [16,17,20,22] or CaPO 4 [21] graft materials to treat patients with benign bone tumors are relatively small with short followup. While various bone graft substitutes may be used to treat bone lesions, common complications still exist [16,17,20,21,24]. One of the major factors in determining the quality of bone graft substitutes is the rate of graft incorporation into the host bone.…”

In Vitro Elution Characteristics of Vancomycin in a Composite Calcium Phosphate/Calcium Sulfate Bone Substitute

“…As with many in vitro studies, a weakness of our experimental design is the inability to recreate physiological in vivo conditions and the effects this may have on our outcomes. Indeed, previous in vivo studies using calcium sulfate alone have reported serous wound drainage due to its swift resorptive profile [9]; this phenomenon would require further in vivo study when in combination with the latently resorbed calcium phosphate. Our laboratories' previous preliminary studies [6] noted the poor elutive characteristics of vancomycin in a pure calcium phosphate carrier; furthermore, at concentrations greater than 4.76%, the handling properties and structural integrity of the cement were notably altered-becoming brittle and losing malleability.…”