The Use of a Novel Drinkometer System for Assessing Pharmacological Treatment Effects on Ethanol Consumption in Rats

Vengeliene, Valentina; Noori, Hamid; Spanagel, Rainer

doi:10.1111/j.1530-0277.2012.01874.x

Cited by 34 publications

(60 citation statements)

References 23 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data are in agreement with previous data suggesting that compulsive drinking behavior occurring in long-term alcohol-experienced rats following a deprivation period circumvents circadian drinking activity Vengeliene et al, 2009;Vengeliene et al, 2012).…”

Section: Discussionsupporting

confidence: 94%

“…Our drinkometer system (Vengeliene et al, 2012) enables continuous longterm monitoring of liquid consumption by amount and time. The system is equipped with four drinking stations, monitored by a computer, enabling a choice of up to four drinking solutions (ie, tap water, 5%, 10%, and 20% ethanol solutions (v/v) or tap water in our alcohol-relapse experiment and saccharin in our second experiment).…”

Section: Drinking Measurements By the Drinkometer Systemmentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of the Casein-Kinase-1-Epsilon/Delta Prevents Relapse-Like Alcohol Drinking

Perreau-Lenz

Vengeliene

Noori

et al. 2012

Neuropsychopharmacol

Self Cite

View full text Add to dashboard Cite

During the past decade, it has been shown that circadian clock genes have more than a simple circadian time-keeping role. Clock genes also modulate motivational processes and have been implicated in the development of psychiatric disorders such as drug addiction. Recent studies indicate that casein-kinase 1ε/δ (CK1ε/δ)--one of the components of the circadian molecular clockwork-might be involved in the etiology of addictive behavior. The present study was initiated to study the specific role of CK1ε/δ in alcohol relapse-like drinking using the 'Alcohol Deprivation Effect' model. The effect of CK1ε/δ inhibition was tested on alcohol consumption in long-term alcohol-drinking rats upon re-exposure to alcohol after deprivation using a four-bottle free-choice paradigm with water, 5%, 10%, and 20% ethanol solutions, as well as on saccharin preference in alcohol-naive rats. The inhibition of CK1ε/δ with systemic PF-670462 (0, 10, and 30 mg/kg) injections dose-dependently decreased, and at a higher dosage prevented the alcohol deprivation effect, as compared with vehicle-treated rats. The impact of the treatment was further characterized using nonlinear regression analyses on the daily profiles of drinking and locomotor activity. We reveal that CK1ε/δ inhibition blunted the high daytime alcohol intake typically observed upon alcohol re-exposure, and induced a phase shift of locomotor activity toward daytime. Only the highest dose of PF-670462 shifted the saccharin intake daily rhythm toward daytime during treatment, and decreased saccharin preference after treatment. Our data suggest that CK1 inhibitors may be candidates for drug treatment development for alcoholism.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Drinking Measurements By the Drinkometer Systemmentioning

confidence: 99%

Inhibition of the Casein-Kinase-1-Epsilon/Delta Prevents Relapse-Like Alcohol Drinking

Perreau-Lenz

Vengeliene

Noori

et al. 2012

Neuropsychopharmacol

Self Cite

View full text Add to dashboard Cite

show abstract

“…For example, quinine-resistant intake under 4-bottle choice is associated with disrupted circadian patterns of intake and increased preference for higher concentrations of alcohol (Spanagel & Hölter, 1999; Vengeliene, Noori, & Spanagel, 2013; Wolffgramm et al, 2000). Further, IAA-drinking rats do not show an alcohol-deprivation effect, although CAA rats do (Simms et al, 2008); we speculate that lack of an ADE indicates that IAA-drinking rats may already be at maximum in terms of expression of pathological drinking.…”

Section: Do Quinine-resistance Models In Rodents Reflect Human Auds?mentioning

confidence: 99%

Rodent models for compulsive alcohol intake

Hopf¹,

Lesscher²

2014

Alcohol

168

176

View full text Add to dashboard Cite

Continued seeking and drinking of alcohol despite adverse legal, health, economic, and societal consequences is a central hallmark of human alcohol use disorders. This compulsive drive for alcohol, defined by resistance to adverse and deleterious consequences, represents a major challenge when attempting to treat alcoholism clinically. Thus, there has long been interest in developing pre-clinical rodent models for the compulsive drug use that characterizes drug addiction. Here, we review recent studies that have attempted to model compulsive aspects of alcohol and cocaine intake in rodents, and consider technical and conceptual issues that need to be addressed when trying to recapitulate compulsive aspects of human addiction. Aversion-resistant alcohol intake has been examined by pairing intake or seeking with the bitter tastant quinine or with footshock, and exciting recent work has used these models to identify neuroadaptations in the amygdala, cortex, and striatal regions that promote compulsive intake. Thus, rodent models do seem to reflect important aspects of compulsive drives that sustain human addiction, and will likely provide critical insights into the molecular and circuit underpinnings of aversion-resistant intake as well as novel therapeutic interventions for compulsive aspects of addiction.

show abstract

“…Recently, Vengeliene and colleagues demonstrated that lamotrigine has potential for treatment of AUDs. Their studies show that treatment of Wistar rats with lamotrigine attenuated the ADE (increased consumption after a period of abstinence/deprivation)(13, 14). Using a drinkometer system, they also demonstrated that the normal pattern of alcohol intake was disrupted by the ADE(14).…”

Section: Lamotriginementioning

confidence: 99%

“…Their studies show that treatment of Wistar rats with lamotrigine attenuated the ADE (increased consumption after a period of abstinence/deprivation)(13, 14). Using a drinkometer system, they also demonstrated that the normal pattern of alcohol intake was disrupted by the ADE(14). Rats increased their approaches to the drinking bottles during the first day of post-abstinence drinking over baseline conditions.…”

Section: Lamotriginementioning

confidence: 99%

Novel anticonvulsants for reducing alcohol consumption: A review of evidence from preclinical rodent drinking models

Padula¹,

McGuier²,

Griffin³

et al. 2013

OA Alcohol

View full text Add to dashboard Cite

Alcohol use disorders (AUDs) are a major public health issue and have an enormous social and economic burden in developed, developing, and third-world countries. Current pharmacotherapies for treating AUDs suffer from deleterious side effects and are only effective in preventing relapse in a subset of individuals. This signifies an essential need for improved medications to reduce heavy episodic drinking and alcohol-related problems. Growing literature has provided support for the use of anticonvulsants in suppressing symptoms induced by alcohol withdrawal. Emerging clinical and preclinical evidence suggests that a number of well-tolerated anticonvulsants may also decrease alcohol drinking. This review will focus on recent evidence supporting the efficacy of novel anticonvulsants in reducing voluntary alcohol consumption in rodent models. The data demonstrate that anticonvulsants reduce drinking in standard home cage two-bottle choice paradigms, self-administration of alcohol in operant chambers, and cue- and stress-induced reinstatement of alcohol seeking behaviors in rats and mice. This review also highlights evidence that some anticonvulsants were only moderately effective in reducing drinking in select strains of rodents or models. This suggests that genetics, possible neuroadaptations, or the pharmacological target affect the ability of anticonvulsants to attenuate alcohol consumption. Nonetheless, anticonvulsants are relatively safe, have little abuse potential, and can work in combination with other drugs. The results from these preclinical and clinical studies provide compelling evidence that anticonvulsants are a promising class of medication for the treatment of AUDs.

show abstract

The Use of a Novel Drinkometer System for Assessing Pharmacological Treatment Effects on Ethanol Consumption in Rats

Cited by 34 publications

References 23 publications

Inhibition of the Casein-Kinase-1-Epsilon/Delta Prevents Relapse-Like Alcohol Drinking

Inhibition of the Casein-Kinase-1-Epsilon/Delta Prevents Relapse-Like Alcohol Drinking

Rodent models for compulsive alcohol intake

Novel anticonvulsants for reducing alcohol consumption: A review of evidence from preclinical rodent drinking models

Contact Info

Product

Resources

About