The Use of a Mixture of Hypericum Perforatum and Azadirachta indica for the Management of Diabetic Foot Ulcers: A Case Series

Abstract

Introduction: Diabetic foot ulcers (DFU) represent a growing health care issue worldwide, representing one of the most dramatic consequences of poorly controlled diabetes. A first successful experience on a patient with extremely advanced feet ulcers treated with a mixture of Hypericum perforatum and Azadirachta indica (Hyperoil™) has induced us to use the same treatment on a series of patients with less severe ulcers. Aim of this report is to summarize the results observed in this case series. Methods: All patients afferent to the Wound Care Units of Pisa, Ragusa and Modena-Italy (WCU) from June 2012 to June 2013 followed a standardized diagnostic/therapeutic scheme to manage diabetes and coexisting conditions. All DFUs were treated with Hyperoil™ at home, when diabetes was well compensated at WCU. Changes in HbA1c, pressure and pain have been evaluated using paired t-test. Results: All the 16 patients recovered their DFUs 2 to 10 months after starting Hyperoil™ treatment. During this period HbA1c improved and pain due to DFUs disappeared in all patients; furthermore, hypertension was better compensated. Conclusion: These preliminary results, belonging to a case series, suggest that using Hyperoil™ for advanced diabetic foot ulcers, together with tight diabetes control, might be a cheap and effective new option for the home management of advanced diabetic foot ulcers.

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21st century: A systematic review

“…During this period, all patients’ HbA1c levels declined, DFU discomfort was reduced, and hypertension was well compensated. These preliminary data showed that utilizing Hyperoil TM in conjunction with strict diabetes control might be a low-cost and effective new home care option for severe DFUs[ 63 ]. Following the successful use of a Hypericum flower extract ( Hypericum perforatum ) and nimh oil ( Azadirachta indica ; Hyperoil) in foot wounds with exposed bone in a patient with bilateral advanced diabetic ulcers, it was hypothesized that the improvement was due to improved glycemic control and peripheral microvascular circulation.…”