The use of a cytokine panel to define the long-term risk stratification of heart failure/death in patients presenting with chest pain to the emergency department

Kavsak, Peter A.; Newman, Alice; Ko, Dennis T.; MacRae, Andrew R.; Jaffe, Allan S.

doi:10.1016/j.clinbiochem.2009.11.004

Cited by 9 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…45,46 Furthermore, these specific markers and assays have been measured in plasma stored for a decade in another population at risk for cardiac injury, thus suggesting clinical utility and mitigating stability issues. 47 As few of the TRIBE participants were off-pump (9%), we could not evaluate whether the use of cardiopulmonary bypass modified the association of angiogenic markers and our specified outcomes. Prior literature has shown an increase in VEGF levels for on-pump versus offpump cardiac surgery patients.…”

Section: Discussionmentioning

confidence: 99%

The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery

Mansour

Zhang

Moledina

et al. 2019

American Journal of Kidney Diseases

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery

Mansour

Zhang

Moledina

et al. 2019

American Journal of Kidney Diseases

View full text Add to dashboard Cite

show abstract

“…Studies with human subjects have shown differences regarding results. Kavsak et al (17), in a study of 216 patients, reported that high IL-6 levels were a significant predictor of HF in the first 6 months, 2 years, and 8 years post-event (6 months: HR 3.79, 95%CI: 1.28–11.19, P=0.016; 2 years: HR 3.27, 95%CI: 1.48–7.20, P=0.003; and 8 years: HR 2.57, 95%CI: 1.58–4.19, P=0.001). Hartford et al (18), in an analysis of 134 patients with AMI after a 30-month follow-up, did not find any significant differences in IL-6 levels between patients who were hospitalized for HF and those who were not (18.9 vs 17.5 pg/mL, P=0.39).…”

Section: Discussionmentioning

confidence: 99%

Interleukin-6 and adhesion molecules VCAM-1 and ICAM-1 as biomarkers of post-acute myocardial infarction heart failure

Lino

Freitas

Meneses

et al. 2019

Braz J Med Biol Res

View full text Add to dashboard Cite

Acute coronary syndromes are associated with a high prevalence of complications including heart failure (HF). The aim of this study was to investigate the association of novel biomarkers with the occurrence of post-acute myocardial infarction (AMI) HF. A prospective study was conducted with patients admitted to the emergency department with ST-segment elevation myocardial infarction (STEMI). Blood and urine samples were collected for analysis of traditional and novel biomarkers, including interleukin-6, vascular cell adhesion molecule 1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1). We compared the levels of these biomarkers between patients with and without post-STEMI HF. A total of 48 patients were assessed, with a prevalence of males. Fifteen patients (31.2%) had post-STEMI HF. Patients with HF had higher mean values of IL-6, VCAM-1, and ICAM-1 compared to those who did not develop HF (57.06 vs 14.03 pg/mL, P=0.001; 1719.58 vs 1304.34 ng/mL, P=0.001; and 1594.20 vs 1158.74 ng/mL, P<0.001, respectively). The three biomarkers were shown to be good predictors of post-STEMI HF (IL-6: AUC 0.786, P=0.002; VCAM-1: AUC 0.797, P=0.001; and ICAM-1: AUC 0.825, P<0.0001), with the respective cutoff points being calculated based on the best sensitivity and specificity indexes (IL-6: 8.67 pg/mL; VCAM-1: 1501.42 ng/mL; and ICAM-1: 1262.38 ng/mL). Of the three biomarkers, only VCAM-1 and ICAM-1 had a direct linear association between them (r=0.470, P<0.0001). IL-6, VCAM-1, and ICAM-1 were associated with the development of new post-AMI HF symptoms, but only VCAM-1 and ICAM-1 correlated with each other, possibly because they have the same pathophysiological mechanism of action.

show abstract

“…These parameters are: type of anticoagulant, assay method, center performing the measurement, type of centrifuge, sex of the participant. These parameters are extremely important to consider when systemic VEGF-A is measured for example as part of a safety evaluation after anti-VEGF therapy or in other fields, where systemic VEGF-A levels are of importance for example in evaluating clinical outcome [ 18 – 20 ] or in providing risk estimates [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Pre-Analytical Parameters Affecting Vascular Endothelial Growth Factor Measurement in Plasma: Identifying Confounders

et al. 2016

View full text Add to dashboard Cite

BackgroundVascular endothelial growth factor-A (VEGF-A) is intensively investigated in various medical fields. However, comparing VEGF-A measurements is difficult because sample acquisition and pre-analytic procedures differ between studies. We therefore investigated which variables act as confounders of VEGF-A measurements.MethodsFollowing a standardized protocol, blood was taken at three clinical sites from six healthy participants (one male and one female participant at each center) twice one week apart. The following pre-analytical parameters were varied in order to analyze their impact on VEGF-A measurements: analyzing center, anticoagulant (EDTA vs. PECT / CTAD), cannula (butterfly vs. neonatal), type of centrifuge (swing-out vs. fixed-angle), time before and after centrifugation, filling level (completely filled vs. half-filled tubes) and analyzing method (ELISA vs. multiplex bead array). Additionally, intrapersonal variations over time and sex differences were explored. Statistical analysis was performed using a linear regression model.ResultsThe following parameters were identified as statistically significant independent confounders of VEGF-A measurements: analyzing center, anticoagulant, centrifuge, analyzing method and sex of the proband. The following parameters were no significant confounders in our data set: intrapersonal variation over one week, cannula, time before and after centrifugation and filling level of collection tubes.ConclusionVEGF-A measurement results can be affected significantly by the identified pre-analytical parameters. We recommend the use of CTAD anticoagulant, a standardized type of centrifuge and one central laboratory using the same analyzing method for all samples.

show abstract

The use of a cytokine panel to define the long-term risk stratification of heart failure/death in patients presenting with chest pain to the emergency department

Cited by 9 publications

References 11 publications

The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery

The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery

Interleukin-6 and adhesion molecules VCAM-1 and ICAM-1 as biomarkers of post-acute myocardial infarction heart failure

Pre-Analytical Parameters Affecting Vascular Endothelial Growth Factor Measurement in Plasma: Identifying Confounders

Contact Info

Product

Resources

About