The Use of a Cell-free Chondroinductive Implant in a Child With Massive Cartilage Loss of the Talus After an Open Fracture Dislocation of the Ankle

Mason, Lyndon; Wilson-Jones, Nick; Williams, Pamela R. D.

doi:10.1097/bpo.0000000000000198

Cited by 4 publications

(1 citation statement)

References 20 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this reason, sustained-release approaches are under development. It has been already suggested in clinical trials that combination of treatments is shown to be more effective than HA alone [55][56][57][58][59][60].…”

Section: Intra-articular Applicationmentioning

confidence: 99%

Hyaluronic Acid

Pereira

Sousa

Cunha³

et al. 2018

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

In recent times, the field of tissue engineering and regenerative medicine (TERM) has considerably increased the extent of therapeutic strategies for clinical application in orthopedics. However, TERM approaches have its rules and requirements, in the respect of the biologic response of each tissue and bioactive agents which need to be considered, respected, and subject of ongoing studies. Different medical devices/products have been prematurely available on the market and used in clinics with limited success. However, other therapeutics, when used in a serious and evidence-based approach, have achieved considerable success, considering the respect for solid expectations from doctors and patients (when properly informed).Orthobiologics has appeared as a recent technological trend in orthopedics. This includes the improvement or regeneration of different musculoskeletal tissues by means of using biomaterials (e.g., hyaluronic acid), stem cells, and growth factors (e.g., platelet-rich plasma). The potential symbiotic relationship between biologic therapies and surgery makes these strategies suitable to be used in one single intervention.However, herein, the recent clinical studies using hyaluronic acid (HA) in the treatment of orthopedic conditions will mainly be overviewed (e.g., osteochondral lesions, tendinopathies). The possibilities to combine different orthobiologic agents as TERM clinical strategies for treatment of orthopedic problems will also be briefly discussed.

show abstract