The Use of 117mSn (Tin) Colloid for Treatment of Naturally Occurring Grade 3 Elbow Osteoarthritis in Client Dogs

Abstract

BackgroundThe pathology associated with elbow dysplasia is progressive and irreversible and long-term prognosis is poor. Evidence has revealed the important role synovitis plays in the pathophysiology of osteoarthritis. The use of radiosynoviothesis has been proposed as an alternative in early therapeutic intervention to prevent, delay or limit joint disease progression. The aim of this study was to evaluate the effect and duration of improvement following intra-articular injection of 117mSn colloid on naturally occurring Grade 3 elbow osteoarthritis in dogs. Dog elbows (15 dogs/27 elbows) were injected with 117mSn colloid and cohorts followed check point assessments on Days 90, 180, 270 and 365 post treatment. Effectiveness was evaluated using: 1) Canine Brief Pain Inventory (CBPI) assessed by the caretaker, and 2) clinician-assessed lameness. Complete blood count, chemistry panel, joint fluid analysis and urinalysis were assessed for safety.ResultsAt least half the dogs showed success at each study time check point (Days 90, 180, 270 and 365) compared with baseline, using the validated CBPI User Guide criteria. Day 270 provided the largest percentage (70%) of successes when compared with baseline. These CBPI findings were corroborated by statistical agreement with success of clinician-assessed lameness. The mean Pain Severity Score (PSS) improved significantly at Days 90, 270 and 365 compared to baseline, while the mean Pain Interference Score (PIS) improved significantly at Day 270 compared to baseline. Safety assessments did not reveal concerns for the study duration.ConclusionsDogs diagnosed with Grade 3 osteoarthritis in at least one elbow benefited by either not worsening or improving over 365 days after treatment with 117mSn colloid. No 117mSn colloid-related safety concerns were observed.