The usage of a three-compartment model to investigate the metabolic differences between hepatic reductase null and wild-type mice

Abstract

The Cytochrome P450 (CYP) system is involved in 90% of the human bodys interactions with xenobiotics and due to this it has become an area of avid research including the creation of transgenic mice. This paper proposes a three compartment model which is used to explain the drug metabolism in the Hepatic Reductase Null (HRN) mouse developed by the University of Dundee (Henderson et al., 2003). The model is compared with a two compartment model using experimental data from studies using wild type and HRN mice. This comparison allowed for metabolic differences between the two types of mice to be isolated. The three sets of drug data (Gefitinib, Midazolam and Thalidomide) showed that the transgenic mouse has a decreased rate of metabolism.

A Model of Oral and Parenteral Drug Administration with Control

“…Numerous models have incorporated optimal control strategies that aim at maximal benefits in the course of chemotherapy. One of such may be found in DePillis and Radunskaya [7]. Seema et al [8] sought treatment regime that could, among other things, minimize the cancer cell count in the treatment of leukaemia.…”