“…Published modeling methods that employ statistical modeling techniques, including survival analysis and individual-based (micro)simulations, can also be used for similar assessments [8,9,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46], but manual control of the population at risk is required in these simplistic approaches. Our proposed model does not have to involve such manual input of the population size at risk because we explicitly model the demographic dynamics and examine the future course of smoking prevalence within our model directly when predicting the numbers of lung cancer cases [25,26,28,31,32,45]. Another direction of possible application would be to explore the effectiveness of additional screening, including regular or non-regular screening with chest X-rays or computed tomography, which is our area of ongoing future study [27,29,30,31,37,42,44].…”