The urinary metabolome in female mink (Mustela neovison) shows distinct changes in protein and lipid metabolism during the transition from diapause to implantation

Hedemann, Mette Skou

doi:10.1007/s11306-017-1200-4

Cited by 4 publications

(1 citation statement)

References 44 publications

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“…It is also possible that the difference in retention of ∑PCBs and ∑TEQs between males and females is related to the lipid content of the scat (6.8% lipid vs 3.1% lipid, respectively) and that there is greater excretion of lipid‐soluble congeners in scat with the higher lipid content. The difference in scat lipid concentrations could be the result of increased oxidation of lipids in the females because of pregnancy .…”

Section: Discussionmentioning

confidence: 99%

Use of polychlorinated biphenyl and toxic equivalent concentrations in scat from mink(Neovison vison) fed fish from the upper Hudson River to predict dietary and hepatic concentrations and health effects

Bursian

Kern

Remington

et al. 2017

Enviro Toxic and Chemistry

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To evaluate health effects associated with consumption of fish contaminated with polychlorinated biphenyls (PCBs) from the upper Hudson River, farm-raised mink were fed diets containing fish collected from the river. Endpoints assessed included adult reproductive performance, offspring growth and mortality, and organ mass and pathology of adults and their offspring. Scat samples were collected from adult males at the time of necropsy and from adult females just prior to whelping. Scat samples were analyzed for PCBs, polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs). The present study provides the results of these analyses and compares ∑PCB and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxic equivalent (TEQ) concentrations in scat with dietary and hepatic concentrations associated with effects reported previously. Dry weight concentrations of ∑PCBs and ∑TEQs in scat generally increased with dietary concentration and reflected corresponding increases in hepatic concentrations of ∑PCBs and ∑TEQs. Maternal concentrations of ∑PCBs in scat expressed on a dry, wet, and lipid weight basis predicted to result in 50% kit mortality (LC50) were 1.0, 0.30, and 12 μg ∑PCBs/g. Concentrations of ∑PCBs in scat expressed on a dry, wet, and lipid weight basis predicted to result in 50% incidence of a previously reported jaw lesion (EC50) were 1.7, 0.48, and 24 μg ∑PCBs/g in adult females and 2.5, 0.87, and 19 μg ∑PCBs/g in adult males. Environ Toxicol Chem 2018;37:563-575. © 2017 SETAC.

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Section: Discussionmentioning

confidence: 99%

Use of polychlorinated biphenyl and toxic equivalent concentrations in scat from mink(Neovison vison) fed fish from the upper Hudson River to predict dietary and hepatic concentrations and health effects

Bursian

Kern

Remington

et al. 2017

Enviro Toxic and Chemistry

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Monitoring and path optimization of catalytic reformer in a refinery: Principal component analysis and A* algorithm application

Li¹,

Ying²,

Yang³

et al. 2022

Expert Systems with Applications

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Urinary and plasma metabolome of farm mink (Neovison vison) after an intervention with raw or cooked poultry offal: a ¹H NMR investigation

Trimigno

Khakimov

Quaade

et al. 2022

Archives of Animal Nutrition

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Deuterium oxide (D2O, 99.9 atom % D), monobasic potassium phosphate (KH2PO4, ≥99.0%), dibasic potassium phosphate (K2HPO4, ≥98.0%), monosodium hydrogen phosphate (NaH2PO4 99% anhydrous), disodium hydrogen phosphate (NaH 2 PO 4 99% anhydrous) 3-(Trimethylsilyl) propionic-2,2,3,3-d4 acid sodium salt (TSP, 98 atom % D, ≥98.0% (NMR)), and sodium azide (NaN3, ≥99.5%) were purchased from Sigma-Aldrich (Søborg, Danmark). Water used throughout the study was purified using a Millipore lab water system (Merck KGaA, Darmstadt, Germany) equipped with a 0.22 μm filter membrane. NMR Sample preparation -BiofluidsA total of 80 μl phosphate buffer was mixed with 720 μl of urine sample in 2.0 ml plastic Eppendorf tubes. Samples were vigorously vortexed for 5 s and a 600 μl aliquot was transferred into NMR SampleJet tubes (Bruker Biospin, Ettlingen, Germany) of L = 103.5 mm and O.D. = 5.0 mm. For plasma samples, a total of 350 μl buffer was mixed with 350 μl of plasma sample.The phosphate buffer was prepared as described by Khakimov et al. (2020). Plasma buffer was prepared as described by Dona et al. [45]. NMR Sample preparation -FeedThree replicates of feed samples for each group and each time-point available were prepared for NMR analysis in two ways: one to obtain the hydrophilic extract and one to obtain the hydrophobic extract. Samples were homogenised with an ultraturrax, then 500 mg were weighted. Twelve millilitre of a methanol/chloroform solution (1:2) were then added and the solution was homogenised, then stored in darkness for 30 min. Four millilitre of deuterated water (D2O) were then added and samples were shaken manually, then stored in darkness in the same manner. Samples were then filtered through Whatman #4 filter paper and centrifuged for 1 h at 1300 rpm and 4°C to separate the two phases. One millilitre of hydrophilic phase was then

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The urinary metabolome in female mink (Mustela neovison) shows distinct changes in protein and lipid metabolism during the transition from diapause to implantation

Abstract: The urinary metabolome in female mink (Mustela neovison) shows distinct changes in protein and lipid metabolism during the transition from diapause to implantation

Cited by 4 publications

References 44 publications

Use of polychlorinated biphenyl and toxic equivalent concentrations in scat from mink(Neovison vison) fed fish from the upper Hudson River to predict dietary and hepatic concentrations and health effects

Use of polychlorinated biphenyl and toxic equivalent concentrations in scat from mink(Neovison vison) fed fish from the upper Hudson River to predict dietary and hepatic concentrations and health effects

Monitoring and path optimization of catalytic reformer in a refinery: Principal component analysis and A* algorithm application

Urinary and plasma metabolome of farm mink (Neovison vison) after an intervention with raw or cooked poultry offal: a ¹H NMR investigation

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The urinary metabolome in female mink (Mustela neovison) shows distinct changes in protein and lipid metabolism during the transition from diapause to implantation

Abstract: The urinary metabolome in female mink (Mustela neovison) shows distinct changes in protein and lipid metabolism during the transition from diapause to implantation

Cited by 4 publications

References 44 publications

Use of polychlorinated biphenyl and toxic equivalent concentrations in scat from mink(Neovison vison) fed fish from the upper Hudson River to predict dietary and hepatic concentrations and health effects

Use of polychlorinated biphenyl and toxic equivalent concentrations in scat from mink(Neovison vison) fed fish from the upper Hudson River to predict dietary and hepatic concentrations and health effects

Monitoring and path optimization of catalytic reformer in a refinery: Principal component analysis and A* algorithm application

Urinary and plasma metabolome of farm mink (Neovison vison) after an intervention with raw or cooked poultry offal: a 1H NMR investigation

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Urinary and plasma metabolome of farm mink (Neovison vison) after an intervention with raw or cooked poultry offal: a ¹H NMR investigation