The Urgent Need for Novel Antimicrobial Agents and Strategies to Fight Antibiotic Resistance

D’Andrea, Marco Maria; Fraziano, Maurizio; Thaller, María Cristina; Rossolini, Gian María

doi:10.3390/antibiotics8040254

Cited by 26 publications

(19 citation statements)

References 11 publications

(15 reference statements)

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“…The overuse, abuse and misuse of antibiotics in humans and animals have accelerated the development and spread of resistances. It has been suggested that the current "antibiotic resistance crisis" may lead us back to a "pre-antibiotic era" if effective actions to significantly decrease antibiotic use are not undertaken rapidly (1)(2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

Replacement of Metaphylactic Antimicrobial Therapy by Oral Administration of Ligilactobacillus salivarius MP100 in a Pig Farm

et al. 2021

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Antibiotic use in swine production contributes to the emergence and spread of resistant bacteria, which poses a threat on human health. Therefore, alternative approaches must be developed. The objective of this work was the characterization of the probiotic properties of a Ligilactobacillus salivarius strain isolated from sow's milk and its application as an inoculated fermented feed to pregnant sows and piglets. The study was carried in a farm in which metaphylactic use of antimicrobials (including zinc oxide) was eliminated at the time of starting the probiotic intervention, which lasted for 2 years. Feces from 8-week-old piglets were collected before and after the treatment and microbiological and biochemical analyses were performed. The procedure led to an increase in the concentrations of clostridia and lactobacilli-related bacteria. Parallel, an increase in the concentration of butyrate, propionate and acetate was observed and a notable reduction in the presence of antibiotic resistant lactobacilli became apparent. In conclusion, replacement of antimicrobials by a microbiota-friendly approach was feasible and led to positive microbiological and biochemical changes in the enteric environment.

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Section: Introductionmentioning

confidence: 99%

Replacement of Metaphylactic Antimicrobial Therapy by Oral Administration of Ligilactobacillus salivarius MP100 in a Pig Farm

et al. 2021

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“…The global spread of antimicrobial resistant bacteria and the emerging consumer trend for natural food preservatives, emphasize the need of exploring novel and natural antimicrobial compounds (Santos-Sanchez et al, 2017;D'Andrea et al, 2019). In this context, microbial diversity in many environments has been a great interest to explore new antimicrobials (Mullis et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Soil Clostridium Enriched Conditioned Media Against Bacillus mycoides, Bacillus cereus, and Pseudomonas aeruginosa

et al. 2020

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The rise of antimicrobial resistant bacteria has fast-tracked the exploration for novel antimicrobial compounds. Reports on antimicrobial producing soil anaerobes such as Clostridium spp. are very limited. In the present study, the antimicrobial activity of soil Clostridium enriched conditioned/spent media (CMs) against Bacillus mycoides, Bacillus cereus and Pseudomonas aeruginosa was assessed by turbidimetric growth inhibition assay. Our results highlighted the antimicrobial potential of soil Clostridium enriched conditioned media against pathogenic and spoilage bacteria. Farm 4 soil conditioned medium (F4SCM) demonstrated a greater growth inhibition activity against all three tested microorganisms in comparison to other soil conditioned media. Non-targeted metabolite profiling of all soil conditioned media revealed distinctive polar and intermediate-polar metabolites in F4SCM, consistent with its strong antimicrobial property. Moreover, 539 significantly abundant metabolites including some unique features were detected in F4SCM suggesting its substantial and specialized chemical diversity. This study putatively identified seven significantly high metabolites in F4SCM; 3-hydroxyphenylacetic acid, γ-aminobutyric acid, creatine, tryptamine, and 2-hydroxyisocaproic acid. Tryptamine and 2-hydroxyisocaproic acid were previously reported to have antimicrobial properties. The present study shows that soil Clostridium spp. are a promising group of bacteria producing metabolites with antimicrobial activity and provides future prospects for clostridial antimicrobial discovery within their metabolic diversity.

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“…In previous hydrogenation conditions, the carbonyl groups at the C-ring were also reduced, which had to be recovered by the DDQ oxidation. 19,20d In addition to the synthesis of (1), removal of the benzyl protecting groups of 17 with BBr 3 furnished the B-ring unsaturated core analogue (2).…”

Section: Resultsmentioning

confidence: 99%

Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties

Lai

Mondal

et al. 2021

RSC Adv.

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The Urgent Need for Novel Antimicrobial Agents and Strategies to Fight Antibiotic Resistance

Abstract: Antibiotic resistance in bacterial pathogens has currently reached very high and alarming levels [...]

Cited by 26 publications

References 11 publications

Replacement of Metaphylactic Antimicrobial Therapy by Oral Administration of Ligilactobacillus salivarius MP100 in a Pig Farm

Replacement of Metaphylactic Antimicrobial Therapy by Oral Administration of Ligilactobacillus salivarius MP100 in a Pig Farm

Antimicrobial Activity of Soil Clostridium Enriched Conditioned Media Against Bacillus mycoides, Bacillus cereus, and Pseudomonas aeruginosa

Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties

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