The Urethral Syndrome — Role of Estrogens in the Therapy

Smith, Patrick J.

doi:10.1007/978-94-011-7230-1_10

Cited by 2 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in accordance with previous studies, suggesting that oestra diol replacement in postmenopausal women may reduce the incidence of urinary tract infections by modifying the vaginal flora [4] and by oestrogen stimulation of the ure thral epithelium. For some time it has been known that the distal urethra is oestrogen-sensitive and with advanc ing age the entire urethra may become oestrogen-sensitive [5,6]. Further evidence of this is provided by the finding of high-affinity oestrogen receptors in the urethra and tri gone [7],…”

Section: Discussionmentioning

confidence: 73%

Clinical Effects of Preoperative Oestradiol Treatment before Vaginal Repair Operation

Mikkelsen

Felding

Clausen

1995

Gynecol Obstet Invest

View full text Add to dashboard Cite

The objective of the study was to assess the effects of low-dose vaginal treatment with oestradiol before vaginal operation. In a double-blind randomized study including 43 postmenopausal women scheduled for vaginal repair operation for genital descensus, it was found that 7 patients suffered from concomitant urinary stress incontinence. Vagifem® (25 µg oestradiol) or placebo was administered as vaginal pessaries daily, 3 weeks prior to surgery and the clinical effects evaluated. One month postoperatively the prevalence of bacteriuria ( > 100,000 CFU/ml urine) was significantly lower when using oestradiol than in the placebo group. At follow-up 3 years later 40 women (93%) answered the questionnaires. None received hormone replacement therapy. Nineteen percent in the preoperative oestradiol group and 11% in the preoperative placebo group had had more than two episodes of cystitis treated with antibiotics. This difference is not statistically significant (p > 0.05). Recurrent cystitis was not correlated to bacteriuria postoperatively. Seventy-nine percent of the women with genital prolapse but only 29% of the women with concomitant urinary stress incontinence were cured (p < 0.05). Neither preoperative oestradiol treatment nor body weight had any influence on relapse. Preoperative low-dose vaginal oestradiol treatment may reduce the incidence of bacteriuria in the immediate postoperative period but no long-lasting effects on recurrent cystitis or relapse were seen. Longer-lasting hormone replacement therapy may be necessary to achieve lasting effects.

show abstract