The Urban Child Institute CANDLE Study: Methodological Overview and Baseline Sample Description

Sontag-Padilla, Lisa; Shih, Regina A.; Griffin, Beth Ann; Martin, Laurie T.; Chandra, Anita; Tylavsky, Frances A.

doi:10.7249/rr1336

Cited by 47 publications

(51 citation statements)

References 55 publications

(65 reference statements)

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“…We studied mother‐infant dyads who were enrolled prenatally (2006‐2011) in CANDLE, a prospective cohort of mother‐infant dyads based at the University of Tennessee Health Science Center, and were also enrolled in TennCare. The cohort was recruited from Shelby County (Memphis), TN, and includes a predominately low‐income, urban, African American population, with 59% of women reporting Medicaid insurance at enrolment . Women who were pregnant (16‐28 weeks gestation; singleton, low‐risk pregnancies), 16 to 40 years of age, English speaking, and residents of Shelby County planning to deliver at designated study health care settings were eligible.…”

Section: Methodsmentioning

confidence: 99%

“…chronic hypertension requiring therapy, acute or chronic hepatitis, human immunodeficiency virus) or severe pregnancy complications (e.g. oligohydramnios, placenta previa) . CANDLE did not exclude women with asthma.…”

Section: Methodsmentioning

confidence: 99%

“…We studied mother-infant dyads who were enrolled prenatally (2006)(2007)(2008)(2009)(2010)(2011) in CANDLE, a prospective cohort of mother-infant dyads based at the University of Tennessee Health Science Center, 21,22 and were also enrolled in TennCare. The cohort was recruited from Shelby County (Memphis), TN, and includes a predominately low-income, urban, African American population, with 59% of women reporting Medicaid insurance at enrolment.…”

Section: Study Design and Populationmentioning

confidence: 99%

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Maternal childhood and lifetime traumatic life events and infant bronchiolitis

Adgent

Elsayed-Ali

Gebretsadik

et al. 2019

Paediatric Perinatal Epid

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Background Viral bronchiolitis is a common respiratory infection that often affects term, otherwise healthy infants. A small literature suggests maternal stress during pregnancy is associated with bronchiolitis. However, the association between maternal exposure to lifetime traumatic stress, including traumatic events occurring in childhood or throughout the life course, and bronchiolitis has not been studied previously. Objectives To investigate the association between maternal exposure to total lifetime and childhood traumatic stress events and infant bronchiolitis. Methods We studied mother‐infant dyads enrolled in a prospective prenatal cohort, recruited 2006‐2011, and Tennessee Medicaid. During pregnancy, we assessed maternal lifetime exposure to types of traumatic events by questionnaire. We captured bronchiolitis diagnoses in term, non‐low birthweight infants’ first 12 months using linked Medicaid data. In separate models, we assessed the association of maternal lifetime traumatic events (0 to 20 types) and a subset of traumatic events that occurred during childhood (0 to 3: family violence, sexual, and physical abuse) and infant bronchiolitis using multivariable log‐binomial models. Results Of 629 women, 85% were African American. The median count (interquartile range) of lifetime traumatic events was 3 (2, 5); 42% reported ≥1 childhood traumatic event. Among infants, 22% had a bronchiolitis diagnosis (0 to 2 lifetime traumatic events: 24%; 3 events: 20%; 4 to 5 events: 18%; 6 or more events: 24%). Total maternal lifetime traumatic events were not associated with bronchiolitis in multivariable analyses. For maternal childhood traumatic events, the risk of infant bronchiolitis increased with number of event types reported: adjusted Risk ratios were 1.12 (95% confidence interval [CI] 0.80, 1.59), 1.31 (95% CI 0.83, 2.07), and 2.65 (95% CI 1.45, 4.85) for 1, 2, and 3 events, respectively, vs none. Conclusions Infants born to women reporting multiple types of childhood trauma were at higher risk for bronchiolitis. Further research is needed to explore intergenerational effects of traumatic experiences.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Study Design and Populationmentioning

confidence: 99%

See 1 more Smart Citation

Maternal childhood and lifetime traumatic life events and infant bronchiolitis

Adgent

Elsayed-Ali

Gebretsadik

et al. 2019

Paediatric Perinatal Epid

View full text Add to dashboard Cite

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“…Predictor variables that accounted for 20% of the variance before entry of the 6th variable in prior modeling would be included in the model. Given the aims of this longitudinal study and the number of variables in the study (Sontag‐Padilla et al, ), detecting small amounts of variance was considered critical to thoughtful examination of factors contributing to child development and related outcomes.…”

Section: Methodsmentioning

confidence: 99%

“…While perinatal studies in and outside of the US have contributed or are expected to contribute to the science on early‐life determinants of neurocognitive development, they have not included data representing predominantly minority populations. A large‐scale, community‐based, longitudinal study (Sontag‐Padilla et al, ) was designed to identify factors that affect a child's development and ability to learn. The primary goal was to investigate the separate and combined effects of maternal behavior, childhood experiences, and the environment on cognitive and social‐emotional development of children through age 3 years in a predominantly Black sample.…”

Section: Parent Studymentioning

confidence: 99%

Maternal and Child Characteristics Associated With Mother–Child Interaction in One‐Year‐Olds

Graff

Bush

Palmer

et al. 2017

Research in Nursing & Health

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Mothers' interactions with their young children have predicted later child development, behavior, and health, but evidence has been developed mainly in at-risk clinical samples. An economically and racially diverse sample of pregnant women who were not experiencing a high-risk pregnancy were recruited to participate in a community-based, longitudinal study of factors associated with child cognitive and social-emotional development during the first 3 years. The purpose of the present analysis was to identify associations between the characteristics of 1125 mothers and their 1-year-olds and the mothers' and children's scores on the Nursing Child Assessment Teaching Scale (NCATS). A multivariable approach was used to identify maternal and child characteristics associated with NCATS scores and to develop prediction models for NCATS total and subscale scores of mothers and children. Child expressive and receptive communication and maternal IQ, marital status, age, and insurance predicted NCATS Mother total score, accounting for 28% of the score variance. Child expressive communication and birth weight predicted the NCATS Child total score, accounting for 4% of variance. Child's expressive communication and mother's IQ and marital status predicted NCATS mother-child total scores. While these findings were similar to reports of NCATS scores in at-risk populations, no previous teams examined all of the mother and child characteristics included in this analysis. These findings support the utility of the NCATS for assessing mother-child interaction and predicting child outcomes in community-based, non-clinical populations. © 2017 Wiley Periodicals, Inc.

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