The upper and lower airway responses to nasal challenge with house‐dust mite Blomia tropicalis

Wang, D. Y.; Goh, Daniel Y T; Ho, A. K. L.; Chew, Fook Tim; Yeoh, Kian Hian; Lee, B. W.

doi:10.1034/j.1398-9995.2003.23746.x

Cited by 30 publications

(31 citation statements)

References 14 publications

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“…This result is very similar to the one obtained in the present study. Other studies in Brazil and Singapore have demonstrated the allergenicity of B. tropicalis in vivo using nasal challenges [36, 37]. In Brazil, a group of D. pteronyssinus - and B. tropicalis -sensitive patients was evaluated; 90% of the patients had a positive nasal challenge to D. pteronyssinus and 60% to B. tropicalis [36].…”

Section: Discussionmentioning

confidence: 99%

Skin Tests and Conjunctival and Bronchial Challenges with Extracts of Blomia tropicalis and Dermatophagoides pteronyssinus in Patients with Allergic Asthma and/or Rhinoconjunctivitis

Robaina

Machín

Fernández-Caldas³

et al. 2003

Int Arch Allergy Immunol

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Background:Blomia tropicalis and Dermatophagoides pteronyssinus are important mite species in Tenerife, Canary Islands, Spain. Several studies have demonstrated a variable degree of allergenic cross-reactivity in vitro. However, only a few have addressed their allergenic cross-reactivity using challenge tests. Objective: The objective of this study was to conduct conjunctival and bronchial challenge tests with B. tropicalis and D. pteronyssinus extracts in a group of 42 patients with allergic asthma and/or rhinoconjunctivitis sensitised to house dust mites (31 females, 11 males; mean age 21.7 ± 7.02 years). Methods: Prick tests using standardised extracts and specific IgE determinations using the CAP system were performed. Bronchial and/or conjunctival challenges were conducted using freeze-dried extracts of both mite species. A patient was considered sensitive to a mite species if she/he had a positive prick and/or CAP test result. A total of 32 conjunctival and 15 bronchial challenges were performed with both mite species. Results: Prick tests were positive to B. tropicalis in 23 patients (54.7%) and to D. pteronyssinus in 41 (97.6%). One patient (2.4%) was exclusively sensitive to B. tropicalis. The CAP test was positive for B. tropicalis in 28 patients and for D. pteronyssinus in 41. Conjunctival challenges to B. tropicalis were positive in 20 patients (18 sensitised and 2 non-sensitised) and negative in 12 (5 sensitised and 7 non-sensitised patients). Conjunctival challenges with D. pteronyssinus were positive in all 31 D. pteronyssinus-sensitised patients who underwent conjunctival challenges. Bronchial challenges with B. tropicalis were positive in 9 sensitised patients and negative in 6 patients (2 sensitised and 4 non-sensitised). Bronchial challenges with D. pteronyssinus were positive in all patients except 1, who only reacted to B. tropicalis. Conclusions: Allergens of the mite species B. tropicalis induce positive conjunctival and bronchial challenges in B. tropicalis-sensitised individuals. Our results suggest that although there is a low to moderate degree of in vivo cross-reactivity between B. tropicalis and D. pteronyssinus, B. tropicalis seems to be a relevant source of allergens in areas where patients are exposed.

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Section: Discussionmentioning

confidence: 99%

Skin Tests and Conjunctival and Bronchial Challenges with Extracts of Blomia tropicalis and Dermatophagoides pteronyssinus in Patients with Allergic Asthma and/or Rhinoconjunctivitis

Robaina

Machín

Fernández-Caldas³

et al. 2003

Int Arch Allergy Immunol

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“…House-dust mites are the most common indoor allergens, playing a pivotal role in the development of allergic diseases, such as allergic rhinitis and asthma [1]. Allergic reactions are triggered as a broad inflammatory cascade governed by multiple mediators including cytokines, specific IgE, mucus, chemokines, adhesion molecules, eosinophils and mast cells, and enhanced airway responsiveness [2].…”

Section: Introductionmentioning

confidence: 99%

Behavioral Conditioning of Antihistamine Effects in Patients with Allergic Rhinitis

Goebel

Meykadeh

Kou

et al. 2008

Psychother Psychosom

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Background: Allergic symptoms can be induced by behavioral conditioning. However, the conditionability of antiallergic effects has not yet been studied. Thus, we investigated whether the effects of a histamine 1 (H₁) receptor antagonist are inducible in patients suffering from house-dust mite allergy using a behavioral conditioning procedure. Methods: During the association phase, 30 patients with allergic house-dust mite rhinitis received a novel-tasting drink once daily, followed by a standard dose of the H₁ receptor antagonist, desloratadine, on 5 consecutive days. After 9 days of drug washout, the evocation trial commenced: 10 patients received water together with an identically looking placebo pill (water group), 11 patients were re-exposed to the novel-tasting drink and received a placebo pill [conditioned stimulus (CS); CS group] and 9 patients received water and desloratadine (drug group). Results: During the association phase, desloratadine treatment decreased the subjective total symptom scores, attenuated the effects of the skin prick test for histamine and reduced basophil activation ex vivo in all groups. During the evocation trial, the water group, in which subjects were not re-exposed to the gustatory stimulus, showed a reduction in subjective total symptom scores and skin prick test results, but no inhibition of basophil activation. In contrast, re-exposure to the novel-tasting drink decreased basophil activation, the skin prick test result and the subjective symptom score in the CS group to a degree that was similar to the effects of desloratadine in the drug group. Conclusions: These data show that behaviorally conditioned effects are not only able to relieve subjective rhinitis symptoms and allergic skin reactions, but also to induce changes in effector immune functions.

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“…LTD4 nasal challenge tests were performed as described previously (14). Briefly, the diluents { [4][5][6][7][8][9][10][11][12][13][14][15][16]×10 −3 mg·mL −1 } were delivered via nasal spray in a step-wise manner with the rate of increase in nasal airway resistance (NAR) and induced symptom scores as the measurement outcomes (15). NAR was measured with an active anterior rhinomanometry by using rhinomanometer (Jaeger, Germany) according to international guideline (16).…”

Section: Measurementsmentioning

confidence: 99%

“…Bronchial hyperresponsiveness (BHR) may have existed in patients with AR who had no clinical manifestation of asthma. BHR reportedly increased after nasal allergen challenges in patients with AR with or without coexisting asthma (4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Effects of leukotriene D4 nasal challenge on bronchial responsiveness and inflammation in asthmatic patients with allergic rhinitis

et al. 2017

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Background: In asthmatic patients with allergic rhinitis (AR), increased cysteinyl leukotrienes (CysLTs) production in the secretion of nasal mucosa has been associated with greater bronchial hyperresponsiveness (BHR) after nasal allergen challenge. However, the role of CysLTs in eliciting BHR after nasal allergen challenge has not been evaluated. The aim of this study is to evaluate the effect of LTD 4 nasal challenge on BHR and inflammation in asthmatic patients with AR. Conclusions:Although most asthmatic patients with AR were sensitive to LTD 4 nasal challenge, LTD 4 nasal provocation tests do not confer any major effect on BHR. LTD 4 might not play a vital role in eliciting bronchial responsiveness induced by nasal allergen challenge.

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The upper and lower airway responses to nasal challenge with house‐dust mite Blomia tropicalis

Abstract: Our study demonstrates direct evidence of allergic nasal response to B. tropicalis in sensitized adults. It shows that nasal provocation may also provoke concomitant asthmatic symptoms during the late-phase reaction, especially in people with a history of asthma.

Cited by 30 publications

References 14 publications

Skin Tests and Conjunctival and Bronchial Challenges with Extracts of <i>Blomia tropicalis</i> and <i>Dermatophagoides pteronyssinus </i>in Patients with Allergic Asthma and/or Rhinoconjunctivitis

Skin Tests and Conjunctival and Bronchial Challenges with Extracts of <i>Blomia tropicalis</i> and <i>Dermatophagoides pteronyssinus </i>in Patients with Allergic Asthma and/or Rhinoconjunctivitis

Behavioral Conditioning of Antihistamine Effects in Patients with Allergic Rhinitis

Effects of leukotriene D4 nasal challenge on bronchial responsiveness and inflammation in asthmatic patients with allergic rhinitis

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