The Unusual Cause of Abdominal Pain in a Patient with Coexistence of Behçet’s Disease and Familial Mediterranean Fever: Cyst Hydatid Disease: Case Report

Erdem, Fazile Hatipoğlu; Karatay, Saliha; Melikoğlu, Meltem Alkan; Şenel, Kazım

doi:10.5336/medsci.2009-13173

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Until now, eighteen different genotypes have been characterized with the greatest diversity of genotypes observed among Turks and Armenians (8). In addition, several disease-associated mutations were identified in the distal part of exon 10 of the MEFV gene, but three of these (M6801, M694V, V726A) appear to account for the majority of clinical FMF cases (9,10).…”

Section: Discussionmentioning

confidence: 99%

Familial Mediterranean Fever Presenting with Perimenstrual Attacks and Infertility

Doğan¹,

Aksel²,

Doğan³

et al. 2013

Istanbul Med J

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Ailesel Akdeniz Ateşi (FMF); Türkler, Ermeniler, Sefarad Yahudileri ve Araplar arasında yaygın olan ve otozomal resesif olarak iletilen bir genetik hastalıktır. FMF kısa süren ve kendini sınırlayan; ateş, peritonit, plevrit ve artrit ataklarıyla seyreder. Ataklar genellikle menstrüasyon dönemlerinin arasında olur. FMF'i olan ve tedavi almayan kadınlarda %30'a varan oranlarda görülen infertilite, ovulatuar bozukluk ve peritoneal yapışıklıklara bağlanmıştır. 34 yaşındaki bayan hasta acil servise 22 yaşından beri yılda 3 kez olan dismenore şikayetiyle başvurdu. Hasta 3 yıldan beri infertilite tedavisi almaktaydı ve hiçbiri gebelikle sonuçlanmayan 3 in vitro fertilizasyon tedavisi almıştı. Biz bu hastanın ağrılı perimenstrüel atakları olan bir FMF hastası olduğunu ve FMF'e bağlı infertilitesi olabileceğini düşündük.Anahtar Kelimeler: Ailesel akdeniz ateşi, infertilite, dismenore Familial Mediterranean fever (FMF) is a genetic disease, transmitted by an autosomal recessive gene prevalent among Turks, Armenians, Sephardic Jews and Arabs. FMF is manifested by short, self-limiting attacks of fever, peritonitis, pleuritis, and arthritis. Usually, patients also have attacks between menstruations. Infertility has been implicated by ovulatory dysfunction and peritoneal adhesions and reported in up to 30% of untreated women with FMF. A 34 year old woman presented to the emergency department with dysmenorrhea three times annually since 22 years of age. She had had infertility treatment for 3 years (three times in vitro fertilization therapy, which had not ended with pregnancy). We thought that this patient, who presented with painful perimenstrual attacks and who had infertility could have FMF.

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Section: Discussionmentioning

confidence: 99%

Familial Mediterranean Fever Presenting with Perimenstrual Attacks and Infertility

Doğan¹,

Aksel²,

Doğan³

et al. 2013

Istanbul Med J

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Concurrence of familial Mediterranean fever and Behçet’s disease: a case report and review of the literature

Mir,

Ivory,

Cowan

2023

J Med Case Reports

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Background Familial Mediterranean fever and Behçet’s disease are distinct disorders that are prevalent in the Mediterranean and Middle Eastern populations. They are characterized by unprovoked inflammatory episodes caused by overexpression of proinflammatory cytokines. Although reported previously, the overlapping presentation of familial Mediterranean fever and Behçet’s disease remains uncommon. Case presentation A 46-year-old Lebanese–Canadian man who presented with recurrent oral and genital ulcers, polyarticular synovitis, ocular swelling, recurrent infections, and fevers was later found to have heterozygous mutations of pathogenic MEFV c.2080A > G (p. Met 694Val) and c.2082G > A (p.Met694IIe) genes indicating familial Mediterranean fever. He was treated with prednisone, colchicine, and azathioprine, with inadequate symptoms control. Treatment was complicated by recurrent infections. Conclusions Our case contributes to the growing literature demonstrating the presentation of predominantly Behçet’s disease-like features in the setting of diagnosis of familial Mediterranean fever. These findings emphasize that clinicians should be aware that patients with familial Mediterranean fever may present with Behçet’s disease-like clinical manifestations.

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The Unusual Cause of Abdominal Pain in a Patient with Coexistence of Behçet’s Disease and Familial Mediterranean Fever: Cyst Hydatid Disease: Case Report

Cited by 2 publications

References 17 publications

Familial Mediterranean Fever Presenting with Perimenstrual Attacks and Infertility

Familial Mediterranean Fever Presenting with Perimenstrual Attacks and Infertility

Concurrence of familial Mediterranean fever and Behçet’s disease: a case report and review of the literature

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