The untapped potential of Gallium 68-PET: The next wave of 68Ga-agents

Comparative preclinical evaluation of 68Ga-NODAGA and 68Ga-HBED-CC conjugated procainamide in melanoma imaging

“…Among radionuclides used in PET, the cyclotron independent radionuclide 68 Ga offers a wellestablished chemistry for the labeling of small molar-weight biomolecules and peptides [22][23][24]. 68 Ga-labeled procainamide shows great potential for diagnosis in a variety of melanomas producing melanin pigment.…”

68Ga-DOTA and analogs: Current status and future perspectives

“…In the nearest future these factors may cause a serious increase in the interest in gallium-68 labeled compounds in biology and medicine. [2][3][4] This review indicates the growing importance of the radiopharmaceuticals labeled with gallium in molecular imaging and shows the perspectives on the use of gallium-68 as a substitute for technetium-99 in some applications.…”

In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer 68Ga-NOTA-c(NGR)

“…Among in vivo, functional imaging techniques, Positron Emission Tomography is one of the most sophisticated methods that also makes it possible to detect tumors with high accuracy and sensitivity followed by easy quantification (Wester 2007 Ga-generators and offers a well-established complexation chemistry for the labeling of biomolecules (Velikyan 2013;Smith et al, 2013;Banerjee and Pomper 2013). To our knowledge, only a few 68 Ga-labeled NGR conjugates were evaluated under preclinical circumstances for CD13-expression-imaging (Zhang et al, 2014;Shao et al, 2014b).…”